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Establishment of a fundamental technology for designing new aptamers using molecular simulation methods

Research Project

Project/Area Number 21K12129
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 62010:Life, health and medical informatics-related
Research InstitutionNihon University

Principal Investigator

YAMAGISHI Kenji  日本大学, 工学部, 准教授 (90460021)

Co-Investigator(Kenkyū-buntansha) 坂本 泰一  千葉工業大学, 先進工学部, 教授 (40383369)
石川 岳志  鹿児島大学, 理工学域工学系, 教授 (80505909)
Project Period (FY) 2021-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2023: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2022: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2021: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsアプタマー / 計算化学 / 分子シミュレーション / 分子動力学計算 / フラグメント分子軌道計算 / 核酸 / シミュレーション / 分子認識 / RNAアプタマー / 分子間相互作用 / 分子シミュレーション解析 / 表面プラズモン共鳴 / 等温滴定型カロリメトリ / 分子設計 / フラグメント分子軌道法 / VIINEC / NMR
Outline of Research at the Start

RNAアプタマーは抗体に代わる次世代技術として、医薬品分野や診断薬分野などで注目されている。本研究はアプタマー設計に、はじめて計算化学という手法を取り入れ、論理的な観点から新しいRNAアプタマーを設計する基盤技術の構築を目指す。これにより、様々な標的分子に特異的に結合するアプタマーを自在に設計することが可能となり、これまで有効な治療法のなかった疾患に対する治療薬の開発につなげられる。

Outline of Final Research Achievements

Aptamers are known to adapt a characteristic conformation and bind to their target molecule with high affinity and specificity. Aptamers are potentially useful agents in various applications such as diagnostics, therapeutics, and biosensing. This study aimed to establish a fundamental technology based on computer simulations for designing new aptamers. We experimentally and computationally analyzed the effects of chemical modifications on the three-dimensional structures of the aptamers and the molecular interactions between aptamers and their target molecules. These results are expected to enhance our understanding of aptamer binding mechanisms.

Academic Significance and Societal Importance of the Research Achievements

アプタマー開発工程において、これまで研究者の経験に頼るところが大きかった「塩基配列の最適化工程」や「修飾置換基の導入工程」に対して、本研究の成果は論理的な知見を提供することができる。これにより、アプタマーの開発効率を飛躍的に向上させられると期待でき、これまでの方法では実現できなかった画期的なアプタマーの開発につながる。

Report

(4 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • Research Products

    (58 results)

All 2024 2023 2022 2021

All Journal Article (18 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 16 results,  Open Access: 8 results) Presentation (37 results) (of which Int'l Joint Research: 7 results,  Invited: 8 results) Book (3 results)

  • [Journal Article] Computational study on the inhibition mechanism of cyclodextran against GTF-SI from Streptococcus mutans focusing on the glucan-binding domain2024

    • Author(s)
      Imamura Wataru、Yamasaki Tomohiro、Kato Hikaru、Ishikawa Takeshi
    • Journal Title

      Carbohydrate Polymer Technologies and Applications

      Volume: 7 Pages: 100473-100473

    • DOI

      10.1016/j.carpta.2024.100473

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Thermodynamic Analysis of Nucleic Acid Aptamers Binding to Their Targets2023

    • Author(s)
      山岸 賢司、坂本 泰一
    • Journal Title

      Netsu Sokutei

      Volume: 50 Issue: 3 Pages: 96-102

    • DOI

      10.11311/jscta.50.3_96

    • ISSN
      0386-2615, 1884-1899
    • Year and Date
      2023-07-25
    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Phylogenetic trees of closely related bacterial species and subspecies based on frequencies of short nucleotide sequences2023

    • Author(s)
      Nakano Yoshio、Domon Yusaku、Yamagishi Kenji
    • Journal Title

      PLOS ONE

      Volume: 18 Issue: 4 Pages: e0268847-e0268847

    • DOI

      10.1371/journal.pone.0268847

    • Related Report
      2023 Annual Research Report 2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Selection of aptamers using β-1,3-glucan recognition protein-tagged proteins and curdlan beads2023

    • Author(s)
      Kumagai Kazuyuki、Okubo Hiroki、Amano Ryo、Kozu Tomoko、Ochiai Masanori、Horiuchi Masataka、Sakamoto Taiichi
    • Journal Title

      The Journal of Biochemistry

      Volume: 174 Issue: 5 Pages: 433-440

    • DOI

      10.1093/jb/mvad059

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Insights into the molecular interaction of cyclodextran with a guest molecule: A computational study2023

    • Author(s)
      Imamura Wataru、Yamasaki Tomohiro、Kato Hikaru、Ishikawa Takeshi
    • Journal Title

      Carbohydrate Polymers

      Volume: 301 Pages: 120315-120315

    • DOI

      10.1016/j.carbpol.2022.120315

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Quantification and Neutralization of the Interfacial Electrostatic Potential and Visualization of the Dispersion Interaction in Visualization of the Interfacial Electrostatic Complementarity2022

    • Author(s)
      Ozono Hiroki、Mimoto Kento、Ishikawa Takeshi
    • Journal Title

      The Journal of Physical Chemistry B

      Volume: 126 Issue: 42 Pages: 8415-8426

    • DOI

      10.1021/acs.jpcb.2c05033

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Structural basis for the interaction between the first SURP domain of the SF3A1 subunit in U2 snRNP and the human splicing factor SF12022

    • Author(s)
      Nameki Nobukazu、Takizawa Masayuki、Suzuki Takayuki、Tani Shoko、Kobayashi Naohiro、Sakamoto Taiichi、Muto Yutaka、Kuwasako Kanako
    • Journal Title

      Protein Science

      Volume: 31 Issue: 10

    • DOI

      10.1002/pro.4437

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Discovery and Structure-Based Optimization of Novel Atg4B Inhibitors for the Treatment of Castration-Resistant Prostate Cancer2022

    • Author(s)
      Kudo Yudai、Endo Satoshi、Fujita Mei、Ota Atsumi、Kamatari Yuji O.、Tanaka Yoshimasa、Ishikawa Takeshi、Ikeda Hayato、Okada Takuya、Toyooka Naoki、Fujimoto Naohiro、Matsunaga Toshiyuki、Ikari Akira
    • Journal Title

      Journal of Medicinal Chemistry

      Volume: 65 Issue: 6 Pages: 4878-4892

    • DOI

      10.1021/acs.jmedchem.1c02113

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Identification of novel chemical compounds targeting filovirus VP40-mediated particle production2022

    • Author(s)
      Urata Shuzo、Omotuyi Olaposi Idowu、Izumisawa Ayako、Ishikawa Takeshi、Mizuta Satoshi、Sakurai Yasuteru、Mizutani Tatsuaki、Ueda Hiroshi、Tanaka Yoshimasa、Yasuda Jiro
    • Journal Title

      Antiviral Research

      Volume: 199 Pages: 105267-105267

    • DOI

      10.1016/j.antiviral.2022.105267

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 計算化学手法を用いた抗体に結合する RNA アプタマーの分子認識機構の解明2021

    • Author(s)
      山岸賢司
    • Journal Title

      月刊「細胞」

      Volume: 715 Pages: 926-929

    • NAID

      40022799112

    • Related Report
      2021 Research-status Report
  • [Journal Article] Computational approach for understanding the biding mechanism of RNA aptamer to human Immunogloblin G2021

    • Author(s)
      Kenji Yamagishi
    • Journal Title

      AGRICULTURAL BIOTECHNOLOGY

      Volume: 67 Pages: 998-1002

    • Related Report
      2021 Research-status Report
  • [Journal Article] Lead Optimization of Influenza Virus RNA Polymerase Inhibitors Targeting PA-PB1 Interaction2021

    • Author(s)
      Mizuta Satoshi、Otaki Hiroki、Ishikawa Takeshi、Makau Juliann Nzembi、Yamaguchi Tomoko、Fujimoto Takuya、Takakura Nobuyuki、Sakauchi Nobuki、Kitamura Shuji、Nono Hikaru、Nishi Ryota、Tanaka Yoshimasa、Takeda Kohsuke、Nishida Noriyuki、Watanabe Ken
    • Journal Title

      Journal of Medicinal Chemistry

      Volume: 65 Issue: 1 Pages: 369-385

    • DOI

      10.1021/acs.jmedchem.1c01527

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Trifluoromethylthiolation of Hindered α-Bromoamides with Nucleophilic Trifluoromethylthiolating Reagents2021

    • Author(s)
      Mizuta Satoshi、Kitamura Kanami、Morii Yuki、Ishihara Jun、Yamaguchi Tomoko、Ishikawa Takeshi
    • Journal Title

      The Journal of Organic Chemistry

      Volume: 86 Issue: 24 Pages: 18017-18029

    • DOI

      10.1021/acs.joc.1c02316

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Interaction Analysis on the SARS-CoV-2 Spike Protein Receptor Binding Domain Using Visualization of the Interfacial Electrostatic Complementarity2021

    • Author(s)
      Ishikawa Takeshi、Ozono Hiroki、Akisawa Kazuki、Hatada Ryo、Okuwaki Koji、Mochizuki Yuji
    • Journal Title

      The Journal of Physical Chemistry Letters

      Volume: 12 Issue: 46 Pages: 11267-11272

    • DOI

      10.1021/acs.jpclett.1c02788

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Visualization of the Interfacial Electrostatic Complementarity: A Method for Analysis of Protein-Protein Interaction Based on Ab Initio Quantum Chemical Calculations2021

    • Author(s)
      Ozono Hiroki、Ishikawa Takeshi
    • Journal Title

      Journal of Chemical Theory and Computation

      Volume: 17 Issue: 9 Pages: 5600-5610

    • DOI

      10.1021/acs.jctc.1c00475

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] The Antiviral Effect of the Chemical Compounds Targeting DED/EDh Motifs of the Viral Proteins on Lymphocytic Choriomeningitis Virus and SARS-CoV-22021

    • Author(s)
      Ngwe Tun Mya Myat、Morita Kouichi、Ishikawa Takeshi、Urata Shuzo
    • Journal Title

      Viruses

      Volume: 13 Issue: 7 Pages: 1220-1220

    • DOI

      10.3390/v13071220

    • NAID

      120007172291

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Amelioration of Alzheimer’s Disease by Gut-Pancreas-Liver-Brain Interaction in an App Knock-In Mouse Model2021

    • Author(s)
      Minamisawa Mayumi、Sato Yuma、Ishiguro Eitarou、Taniai Tetsuyuki、Sakamoto Taiichi、Kawai Gota、Saito Takashi、Saido Takaomi C.
    • Journal Title

      Life

      Volume: 12 Issue: 1 Pages: 34-34

    • DOI

      10.3390/life12010034

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The N93D mutation of the human T-cell leukemia virus type 1 envelope glycoprotein found in symptomatic patients enhances neuropilin-1 b1 domain binding2021

    • Author(s)
      Kusunoki Hideki、Tanaka Toshiyuki、Ohshima Chinatsu、Sakamoto Taiichi、Wakamatsu Kaori、Hamaguchi Isao
    • Journal Title

      Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

      Volume: 1869 Issue: 11 Pages: 140708-140708

    • DOI

      10.1016/j.bbapap.2021.140708

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Presentation] バイオインフォマティクス手法によるライフサイエンス研究2024

    • Author(s)
      山岸賢司
    • Organizer
      第20回RNA工学セミナー(千葉工業大学)
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] ハロゲン交換から考察されるEt3N・3HFのカルボカチオンへの反応性2024

    • Author(s)
      水田賢志、石川岳志
    • Organizer
      日本薬学会第144年会
    • Related Report
      2023 Annual Research Report
  • [Presentation] The role of the NP as a Type I interferon antagonist in the Arenavirus replication2024

    • Author(s)
      A. Miyazaki, T. Ishikawa, Y. Takamatsu, S. Urata
    • Organizer
      The Joint 24th International Conference on Emerging Infectious Diseases in the Pacific Rim of the U.S.-Japan Cooperative Medical Sciences Program (USJCMSP)
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Conformational behavior, dynamics, and affinity of A18-modified aptamers toward human Immunoglobulin G2023

    • Author(s)
      Ozora Kudo, Akari Endo, Masahiro Sekiguchi, Azumi ito, Takeshi Ishikawa, Taiichi Sakamoto, Kenji Yamagishi
    • Organizer
      CBI学会2023年大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 抗体に結合するaptamerの改変体の結合能の解析2023

    • Author(s)
      遠藤朱梨,伊藤愛純,関口真裕,阪本智樹,片平正人,永田崇,石川岳志,山岸賢司,坂本泰一
    • Organizer
      2023年度日本生化学会関東支部例会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Effect of modification on the aptamer that binds to IgG2023

    • Author(s)
      Akari Endo, Azumi Ito, Masahiro Sekiguchi, Tomoki Sakamoto, Masato Katahira, Takashi Nagata, Takeshi Ishikawa, Kenji Yamagishi, Taiichi Sakamoto
    • Organizer
      The 14th International Symposium of Advanced Energy Science
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 抗体に結合するaptamerの改変体の結合能の解析2023

    • Author(s)
      遠藤朱梨,関口真裕,阪本智樹,堀内正隆,石川岳志,片平正人,永田崇,山岸賢司,坂本泰一
    • Organizer
      46回日本分子生物学会
    • Related Report
      2023 Annual Research Report
  • [Presentation] IgG1に対するRNA aptamerとChimera aptamerの構造特性の比較2023

    • Author(s)
      長谷川 拓矢,阪本智樹,関口真裕,石川岳志,片平正人,永田崇,山岸賢司,坂本泰一
    • Organizer
      第46回日本分子生物学会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Effect of hydrophobic groups incorporated into gelatin hydrogel as drug carriers on release behavior of hydrophobic medicines2023

    • Author(s)
      Takanori Matsumoto, Takeshi Ishikawa, Hayato Takase, Masahiro Yoshida, Takayuki Takei
    • Organizer
      International Symposium on Chemical Engineering 2023(ISChE2023)
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of a protein-ligand docking method based on molecular dynamics simulation and its application to anti-prion compounds2023

    • Author(s)
      Takeshi Ishikawa
    • Organizer
      NDSU-KU 8th Annual Symposium
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] フニンウイルスNPエキソヌクレアーゼ活性部位のウイルス増殖における役割解明2023

    • Author(s)
      宮崎あんず、石川岳志、高松由基、浦田秀造
    • Organizer
      第70回日本ウイルス学会学術集会
    • Related Report
      2023 Annual Research Report
  • [Presentation] モルフォリノ核酸のNMR解析2023

    • Author(s)
      坂本泰一,佐藤一樹,和田猛
    • Organizer
      日本核酸医薬学会第8回年会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 求核的トリフルオロメチルチオ化試薬を用いたα-SCF3化アミド類の合成法の開発2023

    • Author(s)
      水田賢志、田平将大、森井優樹、石原淳、石川岳志
    • Organizer
      日本薬学会第143年会
    • Related Report
      2022 Research-status Report
  • [Presentation] バイオ医薬品開発の効率化を実現する生体分子量子化学計算プログラム「PAICS」2023

    • Author(s)
      石川岳志, 志々目裕太
    • Organizer
      PARKS起業活動支援プログラム・Demo Day
    • Related Report
      2022 Research-status Report
  • [Presentation] 計算化学を用いたアプタマーの革新的デザイン技術2022

    • Author(s)
      山岸賢司
    • Organizer
      イノベーションジャパン/JST事業採択課題展示特別枠
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] 生体分子シミュレーション  -核酸医薬品開発への展開-2022

    • Author(s)
      山岸賢司
    • Organizer
      第4回ファーマラボEXPO
    • Related Report
      2022 Research-status Report
  • [Presentation] In silico approach for identification of the thermodynamic profiles of aptamer-IgG binding2022

    • Author(s)
      Ryoji Yamazaki, Azumi Ito, Tomoki Sakamoto, Masaki Komine, Takeshi Ishikawa, Masato Katahira, Takashi Nagata, Taiichi Sakamoto, Kenji Yamagishi
    • Organizer
      第60回日本生物物理学会年会
    • Related Report
      2022 Research-status Report
  • [Presentation] Effect of chemical modification on the aptamer that binds to IgG2022

    • Author(s)
      Azumi Ito, Yuuki Yatabe, Hisae Yoshida, Masahiro Sekiguchi, Kazumasa Akita, Yoshikazu Nakamura, Yusuke Nomura, Takeshi Ishikawa, Kenji Yamagishi, Taiichi Sakamoto
    • Organizer
      第60回日本生物物理学会年会
    • Related Report
      2022 Research-status Report
  • [Presentation] Conformational behavior and dynamics of G7A mutant IgG-aptamer2022

    • Author(s)
      Seiichiro Ishii, Ryoji Yamazaki, Oozora Kudo, Taiichi Sakamoto, Takeshi Ishikawa, Kenji Yamagishi
    • Organizer
      CBI学会2022年大会
    • Related Report
      2022 Research-status Report
  • [Presentation] Development and Application of a Computational Method for Analyzing Protein-Protein Interaction2022

    • Author(s)
      Takeshi Ishikawa
    • Organizer
      NDSU-KU 7th Annual Symposium
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Development and Application of a Quantum Chemistry-Based Method for Analyzing Protein-Protein Interaction2022

    • Author(s)
      Takeshi Ishikawa
    • Organizer
      The 20th Protein Island Matsuyama International Symposium
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 抗体医薬品開発を加速するタンパク間相互作用(PPI)解析のためのインシリコ技術「VIINEC」2022

    • Author(s)
      石川岳志
    • Organizer
      Bio Japan
    • Related Report
      2022 Research-status Report
  • [Presentation] The molecular interaction of cyclodextran with a guest molecule using quantum chemical calculation and molecular dynamics simulation2022

    • Author(s)
      Wataru Imamura, Takeshi Ishikawa
    • Organizer
      NDSU-KU 7th Annual Symposium
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] 核酸医薬のNMR解析2022

    • Author(s)
      坂本泰一
    • Organizer
      よこはまNMR研究会第69回ワークショップ「RNA構造とNMR」
    • Related Report
      2022 Research-status Report
  • [Presentation] Effect of chemical modification on the aptamer that binds to IgG,Improvement of binding activity by introducing chemical modification to the aptamer that binds to IgG2022

    • Author(s)
      Azumi Ito, Yuuki Yatabe, Hisae Yoshida, Masahiro Sekiguchi, Kazumasa Akita, Yoshikazu Nakamura, Yusuke Nomura, Takeshi Ishikawa, Kenji Yamagishi, Taiichi Sakamoto
    • Organizer
      The 13th International Symposium of Advanced Energy Science
    • Related Report
      2022 Research-status Report
  • [Presentation] Biophysical study of the aptamer that binds to a target protein2022

    • Author(s)
      Taiichi Sakamoto
    • Organizer
      The 7th International Symposium on Drug Discovery and Design by NMR
    • Related Report
      2022 Research-status Report
  • [Presentation] RNAの立体構造および相互作用の計算化学2022

    • Author(s)
      山岸賢司
    • Organizer
      mRNAターゲット創薬研究機構「2021年度 第2回講演会」
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 核酸・タンパク質などの生体高分子の分子シミュレーション2022

    • Author(s)
      山岸賢司
    • Organizer
      福島地区・高分子学会東北支部講演会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 計算化学を基盤としたアプタマーの論理的な設計指針の確立を目指して2021

    • Author(s)
      山岸賢司
    • Organizer
      化学系学協会東北大会 若手シンポジウム
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 核酸医薬のNMR2021

    • Author(s)
      坂本泰一
    • Organizer
      2021年度 日本分光学会NMR分光部会 集中講義
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] デオキシリボヌクレオチドとリボヌクレオチドの違いによるIgG アプタマーの結 合プロファイルの解析2021

    • Author(s)
      山崎凌司, 金田一樹, 吉田尚恵, 坂本泰一, 石川岳志, 山岸賢司
    • Organizer
      化学系学協会東北大会
    • Related Report
      2021 Research-status Report
  • [Presentation] 分子動力学計算を用いたIgGアプタマーの構造ダイナミクスの塩基配列・塩基修飾依存性2021

    • Author(s)
      金沢拓土, 金田一樹, 山岸賢司
    • Organizer
      化学系学協会東北大会
    • Related Report
      2021 Research-status Report
  • [Presentation] 分子シミュレーションを用いたヒト抗体(IgG)に特異的に結合する新規修飾アプタマーの分子設計2021

    • Author(s)
      金田一樹, 石 井清一郎, 坂本泰一, 石川岳志, 山岸賢司
    • Organizer
      化学系学協会東北大会
    • Related Report
      2021 Research-status Report
  • [Presentation] 分子動力学計算による抗体に結合するRNAアプタマーの立体構造解析2021

    • Author(s)
      山崎凌司,山岸賢司
    • Organizer
      日本コンピュータ化学会2021年秋季年会
    • Related Report
      2021 Research-status Report
  • [Presentation] RNAアプタマーのDNA置換の物理化学的解析2021

    • Author(s)
      坂本 泰一,山岸賢司
    • Organizer
      第44回日本分子生物学会年会
    • Related Report
      2021 Research-status Report
  • [Presentation] ドッキング計算を利用したヒト主要組織適合抗原とペプチドの結合親和性計算法の開発2021

    • Author(s)
      石川岳志
    • Organizer
      CBI学会2021年大会(フォーカストセッション)
    • Related Report
      2021 Research-status Report
  • [Presentation] Visualization of the interfacial electrostatic complementarity: A method for analysis of protein-protein interaction based on fragment molecular orbital method2021

    • Author(s)
      H. Ozono, Takeshi Ishikawa
    • Organizer
      CBI学会2021年大会
    • Related Report
      2021 Research-status Report
  • [Book] 【分担執筆】タンパク質の構造解析手法と In silicoスクリーニングへの応用事例,「第8節 生体分子シミュレーションによる核酸医薬品開発への展開タンパク質の構造解析手法とIn silicoスクリーニングへの応用事例」2023

    • Author(s)
      山岸賢司、石川岳志
    • Total Pages
      530
    • Publisher
      技術情報協会
    • ISBN
      9784861049712
    • Related Report
      2023 Annual Research Report
  • [Book] 【分担執筆】mRNAの制御機構の解明と治療薬・ワクチンへの活用,「第6節 mRNAの制御機構の解明と治療薬・ワクチンへの活用」2023

    • Author(s)
      山岸賢司、坂本泰一
    • Total Pages
      411
    • Publisher
      技術情報協会
    • ISBN
      9784861049378
    • Related Report
      2023 Annual Research Report
  • [Book] 「mRNAの制御機構の解明と治療薬・ワクチンへの活用」-RNAの立体構造と計算化学-2023

    • Author(s)
      山岸賢司,坂本泰一
    • Total Pages
      411
    • Publisher
      技術情報協会
    • ISBN
      9784861049378
    • Related Report
      2022 Research-status Report

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Published: 2021-04-28   Modified: 2025-01-30  

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