| Project/Area Number |
21K12713
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 90130:Medical systems-related
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| Research Institution | Toho University |
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Principal Investigator |
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Project Status |
Completed (Fiscal Year 2023)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2023: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2022: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 7T-MRI / meglumine-gadopentetate / gadobutrol-glucose / molecular imaging / long visualizing / photon counting / PCCT / enhanced K-edge CT / 癌造影 / ブドウ糖・ガドペント酸メグルミン / ブドウ糖・ガドキセト酸ナトリウム / フォトカウンティングCT / テルル化カドミウム / CdTeアレー / ガドリニウムKエッジCT / ブドウ糖・ガドブトロール / フォトンカウンティングCT / ガドリニウムＫエッジCT / フォトンカウンティングX線CT / 分子イメージング |
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| Outline of Research at the Start |
低濃度のMRI用ガドリニウム（Gd）系造影剤を使って新生血管が豊富な癌増殖領域は造影できるが，低酸素領域の描出は難しい。
そこで、本研究では，①ブドウ糖，低濃度MRI用造影剤，そして7T-MRIを利用する高い空間・コントラスト分解能の新しい癌の分子イメージング法を開発すること，②低酸素領域の癌を描出すること，③テルル化カドミウムアレーや新しいフォトンカウンティング素子を使って0.1mm程度の空間分解能で癌部位を描出すること，そして④7T-MRIとエネルギー弁別CTにより得られた画像をマルチモーダル的に利用することを目的としている。
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| Outline of Final Research Achievements |
Using vein infusion of linear-chelate meglumine-gadopentetate-glucose solution from a rabbit ear, 7T-MRI and T1WI, whole cancerous regions in a rabbit were observed with a high contrast and spatial resolutions of 0.5 mm. In our research, meglumine-gadopentetate molecules were absorbed into cancerous region along with glucose molecules. Using cyclic-chelate gadobutrol solution, the same results were obtained. Subsequently, we built a PCCT scanner using a CdTe FPD and performed K-edge CT with spatial resolutions of 0.08mm using gadolinium and iodine contrast media. In combination with 7T-MRI, PCCT can be applied to molecular imaging for cancer diagnosis.
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| Academic Significance and Societal Importance of the Research Achievements |
We performed 7T-MRI using meglumine-gadopentetate-glucose and gadobutrol-glucose solutions to observe whole cancer including hypoxic regions. Furthermore, PCCT using a CdTe FPD is useful for performing enhanced K-edge CT, and multimodal molecular imaging can also be carried out.
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