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The chemical diversity and health functionality of Petasites japonicus focused on "chemotaxonomy"

Research Project

Project/Area Number 21K13508
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 08030:Family and consumer sciences, and culture and living-related
Research InstitutionIwate Biotechnology Research Center

Principal Investigator

Uesugi Shota  公益財団法人岩手生物工学研究センター, 生物資源研究部, 主任研究員 (30795901)

Project Period (FY) 2021-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2022: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2021: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsフキ属 / 山菜 / 成分多様性 / 健康機能性 / 化学分類
Outline of Research at the Start

キク科フキ属に分類される山菜であるフキ・フキノトウは、機能性素材の原料として有望な機能性を有するが、“化学分類”と考えられる主成分の多様性があり、その実態が十分に解明されていない。そこで本研究では、フキ・フキノトウの成分多様性を把握した上で、主な成分を単離同定し、化学分類の全体像を解明する。さらに、国産のフキ・フキノトウ品種を対象とし、化学分類と機能性素材としての適性(健康機能性・安全性・呈味性等)を解明する。以上、我が国独自の伝統食材“山菜”を対象とし、“化学分類”と“健康機能性”を融合することで、成分と機能性に関する学術基盤の整備と、新たな視点での機能性素材としての活用法創出を目指す。

Outline of Final Research Achievements

In this study, we elucidated the chemical diversity and health functionality of Petasites japonicus. Five terpenoids that determine the chemotaxonomy of this plant were identified. Using these compounds as standards, the chemotaxonomy of domestic cultivars were clarified. Petasin, a characteristic terpenoid of Petasites sp., inhibited lipid accumulation through suppression of lipid synthesis-related genes expression. Additionally, we found that one of the domestic cultivars has significant low content of pyrrolizidine alkaloids which are related to toxicity.

Academic Significance and Societal Importance of the Research Achievements

山菜は、文化や地域産業において重要な食資源であるが、機能性については未解明な点が多い。有用な機能性とそれを担う成分を明らかにすることで、高付加価値化・用途拡大に繋がる。特に、本課題では国産品種を対象としており、それぞれの特徴の解明により地域の産業振興に貢献し得る。また、実態が不明な化学分類の解明は、学術的に新規な知見に繋がる可能性を持っている。そして、その成果を成分育種へと応用することで、優れた成分特性を併せ持つ新品種の開発等、新たな視点・方法での山菜の活用法創出に貢献し、我が国独自の食資源である山菜の価値再発見に役立つことが期待される。

Report

(3 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • Research Products

    (20 results)

All 2023 2022 2021 Other

All Journal Article (6 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 6 results) Presentation (12 results) (of which Int'l Joint Research: 3 results,  Invited: 1 results) Remarks (2 results)

  • [Journal Article] Antioxidant p-terphenyl compound, isolated from edible mushroom, Boletopsis leucomelas2022

    • Author(s)
      Sofian FF, Kikuchi N, Koseki T, Kanno Y, Uesugi S, Shiono Y
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 86 Issue: 3 Pages: 300-304

    • DOI

      10.1093/bbb/zbab224

    • Related Report
      2022 Annual Research Report 2021 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Petasin is the main component responsible for the anti-adipogenic effect of Petasites japonicus2022

    • Author(s)
      Uesugi S, Hakozaki M, Kanno Y, Shiraishi A, Suzuki M, Kimura K, Shiono Y, Yano A
    • Journal Title

      Fitoterapia

      Volume: 157 Pages: 105130-105130

    • DOI

      10.1016/j.fitote.2022.105130

    • Related Report
      2022 Annual Research Report 2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Bidysoxyphenols A-C, dimeric sesquiterpene phenols from the leaves of Dysoxylum parasiticum (Osbeck) Kosterm2022

    • Author(s)
      Sofian FF, Subarnas A, Hakozaki M, Uesugi S, Koseki T, Shiono Y
    • Journal Title

      Fitoterapia

      Volume: 158 Pages: 105157-105157

    • DOI

      10.1016/j.fitote.2022.105157

    • Related Report
      2022 Annual Research Report 2021 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Tridysoxyphenols A and B, two new trimeric sesquiterpene phenols from Dysoxylum parasiticum leaves2022

    • Author(s)
      Sofian FF, Subarnas A, Hakozaki M, Uesugi S, Koseki T, Shiono Y
    • Journal Title

      Phytochemistry Letters

      Volume: 50 Pages: 134-140

    • DOI

      10.1016/j.phytol.2022.06.004

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Anti-melanogenic effect of furanoeremophilanes identified from edible wild plants belonging to the genus Cacalia2022

    • Author(s)
      Uesugi S, Hakozaki M, Kanno Y, Takahashi Y, Shindo K, Kimura K, Yano A
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 86 Issue: 10 Pages: 1462-1466

    • DOI

      10.1093/bbb/zbac124

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A yeast-based screening system identified bakkenolide B contained in Petasites japonicus as an inhibitor of interleukin-2 production in a human T cell line2021

    • Author(s)
      Uesugi S, Hakozaki M, Kanno Y, Takahashi H, Kudo Y, Kimura K, Yamada H, Yano A
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 85 Issue: 10 Pages: 2153-2160

    • DOI

      10.1093/bbb/zbab130

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Presentation] 焙煎漆種子熱水抽出物(漆茶)の血圧上昇抑制作用2023

    • Author(s)
      上杉祥太、杉山育美、箱崎真友佳、菅野裕子、丹場晴也、木村賢一、松沢卓生、佐塚泰之、矢野明
    • Organizer
      日本農芸化学会2023年度大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] フキ・フキノトウにおける新規ケモタイプの発見と主成分による抗ヒスタミン薬抵抗性克服戦略2023

    • Author(s)
      上杉祥太、箱崎真友佳、菅野裕子、丹場晴也、木村賢一、矢野明
    • Organizer
      日本農芸化学会2023年度大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 甘茶に含まれるウイルス-受容体結合阻害成分2023

    • Author(s)
      矢野明、結城彩花、菅野裕子、白石朗子、上杉祥太
    • Organizer
      日本農芸化学会2023年度大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 3,6-Epidioxy-1,10-bisaboladiene(EDBD)とスルファサラジンは乳がん細胞に相乗的に細胞死を誘導する2023

    • Author(s)
      Uskhbayar Narandulam、上杉祥太、木村賢一
    • Organizer
      日本農芸化学会2023年度大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Cacalia属山菜に含まれるメラニン産生抑制物質の同定2022

    • Author(s)
      上杉祥太、箱崎真友佳、菅野裕子、髙橋優太、新藤一敏、木村賢一、矢野明
    • Organizer
      令和4年度日本農芸化学会北海道・東北支部合同支部会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 農林水産物に含まれる機能性成分の理解と活用に向けた基礎・応用研究2022

    • Author(s)
      上杉祥太
    • Organizer
      2022年度日本農芸化学会東北支部シンポジウム
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] ウニの消化管および生殖巣中のβ-カロテンとβ-エキネノンの定量および相関分析2022

    • Author(s)
      佐野真生、濱遥香、上杉祥太、結城彩花、矢野明、下荢坪之典、今村聖祐、井戸篤史、都木靖彰、浦和寛
    • Organizer
      令和4年度日本水産増殖学会第20回大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Undescribed dimeric- and trimeric-sesquiterpene phenols and a bicoumarin derivative isolated from the leaves of Dysoxylum caulostachyum Miq., a primate-consumed plant2022

    • Author(s)
      Ferry Ferdiansyah Sofian, Anas Subarnas, Mayuka Hakozaki, Shota Uesugi, Takuya Koseki, Yoshihito Shiono
    • Organizer
      日本農芸化学会2022年度大会
    • Related Report
      2021 Research-status Report
  • [Presentation] フキ・フキノトウに含まれる脂肪蓄積抑制成分petasinの同定と作用機序解析2021

    • Author(s)
      上杉祥太、箱崎真友佳、菅野裕子、白石朗子、鈴木瑞季、木村賢一、塩野義人、矢野明
    • Organizer
      日本農芸化学会東北支部第156回大会
    • Related Report
      2021 Research-status Report
  • [Presentation] Elucidation of a partial polymer structure of Kuji amber2021

    • Author(s)
      Junpei Abe, Hiroyuki Koshino, Kazuyoshi Oikawa, Yuka Miura, Shota Uesugi, Masayuki Shirai, Ken-ichi Kimura
    • Organizer
      Pacifichem2021
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Analysis of functional mechanism and target molecules of ricinoleic acid derived from castor oil2021

    • Author(s)
      Jun Yoshida, Yusuke Okawa, Takuya Oyama, Nozomu Shimoda, Shota Uesugi, Hiroshi Takagi, Yoshiaki Ito, Ken-ichi Kimura
    • Organizer
      Pacifichem2021
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Bioactive properties of non-methylene-interrupted dienoic fatty acids in eukaryotic cells2021

    • Author(s)
      Jun Yoshida, Shota Uesugi, Tetsuaki Kawamura, Ken-ichi Kimura, Dawei Hu, Shuang Xia, Naoki Toyooka, Masao Ohnishi, Hideki Kawashima
    • Organizer
      Pacifichem2021
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Remarks] 岩手生物工学研究センター 生物資源研究部 健康機能研究チーム

    • URL

      https://bioresources.ibrc.or.jp/

    • Related Report
      2022 Annual Research Report
  • [Remarks] 公益財団法人岩手生物工学研究センター 健康機能研究チーム

    • URL

      https://bioresources.ibrc.or.jp/

    • Related Report
      2021 Research-status Report

URL: 

Published: 2021-04-28   Modified: 2024-01-30  

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