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Investigation of hemisphere laterality of abnormal auditory processing in schizophrenia

Research Project

Project/Area Number 21K13753
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 10040:Experimental psychology-related
Research InstitutionUniversity of Miyazaki (2023)
Kyushu University (2021-2022)

Principal Investigator

Shunsuke Tamura  宮崎大学, 医学部, 助教 (20883333)

Project Period (FY) 2021-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2023: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2022: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2021: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords神経オシレーション / 統合失調症 / 大脳半球左右差 / 音声 / 音楽 / 音声・音楽
Outline of Research at the Start

本研究では, 言語音声聴取時に左半球優位性の情報処理が働きにくいとされる統合失調症者を対象とした脳機能計測実験を行い, その異常が言語情報の処理異常を表すのか, 時間情報の処理異常を表すのかを検討することを通して, 聴覚情報処理における大脳半球機能差のメカニズムを議論する。そこで, 言語音声や音楽の持つ様々な速さの時間変動を制御した聴覚刺激を作成し, それらの時間変動に同期して生じる神経振動の左右半球差が, 健常者と統合失調症者の間でどのように異なるのかを調べる。聴覚情報処理における大脳半球優位性の異常が統合失調症やその主症状である言語性幻聴のバイオマーカーとなる可能性についても検討する。

Outline of Final Research Achievements

In this study, we investigated the mechanism underlying hemispheric laterality in auditory information processing and its abnormality in schizophrenia by examining the neural activity phase-locking to temporal modulation of speech and music stimuli. Our findings suggest that the auditory cortex of the the right hemisphere is responsible for nonverbal auditory information processing that commonly occurs during both listening to speech and music stimuli, while the auditory cortex in the left hemisphere is activated when speech information processing is needed. In addition, we obtained the results indicating that the abnormal information processing in the auditory cortex of the left hemisphere in schizophrenia is speech-specific.

Academic Significance and Societal Importance of the Research Achievements

本研究では, 言語音声聴取時に左半球優位の脳内処理が働きにくいとされる統合失調症者を対象とした脳機能計測実験を行い, その異常が言語情報に特化した処理異常であるのか, 時間情報に特化した処理異常であるのかについて検討を行った。疾患研究を通して聴覚情報処理における大脳半球機能差のメカニズムについて議論を深めることが出来たことは学術的意義が非常に大きいと考えられる。また, 統合失調症において聴覚情報処理の大脳半球機能差を生み出すメカニズムを議論をすることはその主症状である言語性幻聴のバイオマーカーを発見することにもつながるため, 臨床的(社会的)意義も非常に大きいものだと考えられる。

Report

(4 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • Research Products

    (36 results)

All 2024 2023 2022 2021

All Journal Article (11 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 11 results,  Open Access: 11 results) Presentation (25 results) (of which Int'l Joint Research: 10 results,  Invited: 1 results)

  • [Journal Article] Contributions of temporal envelope and temporal fine structure to segregation of Lombard speech from background noise2024

    • Author(s)
      Tamura Shunsuke、Mizumachi Mitsunori
    • Journal Title

      Acoustical Science and Technology

      Volume: 45 Issue: 1 Pages: 33-44

    • DOI

      10.1250/ast.e23.24

    • ISSN
      0369-4232, 1346-3969, 1347-5177
    • Year and Date
      2024-01-01
    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Aberrant thalamocortical connectivity and shifts between the resting state and task state in patients with schizophrenia2024

    • Author(s)
      Takai Yoshifumi、Tamura Shunsuke、Hoaki Nobuhiko、Kitajima Kazutoshi、Nakamura Itta、Hirano Shogo、Ueno Takefumi、Nakao Tomohiro、Onitsuka Toshiaki、Hirano Yoji*
    • Journal Title

      European Journal of Neuroscience

      Volume: 59 Issue: 8 Pages: 1961-1976

    • DOI

      10.1111/ejn.16298

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Abnormal connectivity and activation during audiovisual speech perception in schizophrenia2023

    • Author(s)
      Hirano Yoji、Nakamura Itta、Tamura Shunsuke
    • Journal Title

      European Journal of Neuroscience

      Volume: 59 Issue: 8 Pages: 1918-1932

    • DOI

      10.1111/ejn.16183

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Abnormal phase entrainment of low- and high-gamma-band auditory steady-state responses in schizophrenia2023

    • Author(s)
      Nakanishi Shoichiro、Tamura Shunsuke、Hirano Shogo、Takahashi Junichi、Kitajima Kazutoshi、Takai Yoshifumi、Mitsudo Takako、Togao Osamu、Nakao Tomohiro、Onitsuka Toshiaki、Hirano Yoji
    • Journal Title

      Frontiers in Neuroscience

      Volume: 17 Pages: 1277733-1277733

    • DOI

      10.3389/fnins.2023.1277733

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cortical representation of speech temporal information through high gamma-band activity and its temporal modulation2023

    • Author(s)
      Tamura Shunsuke、Hirano Yoji
    • Journal Title

      Cerebral Cortex

      Volume: 33 Issue: 13 Pages: 8773-8782

    • DOI

      10.1093/cercor/bhad158

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Decrease in Gamma-band Auditory Steady-State Response in Patients with Treatment-resistant Schizophrenia: Schizophrenia Research2023

    • Author(s)
      Kamiyu Ogyu, Karin Matsushita, Shiori Honda, Masataka Wada, Shunsuke Tamura, Kazumasa Takenouchi, Yui Tobari, Keisuke Kusudo, Hideo Kato, Teruki Koizumi, Naohiro Arai, Akihiro Koreki, Mie Matsui, Hiroyuki Uchida, Shinya Fujii, Mitsumoto Onaya, Yoji Hirano, Masaru Mimura, Shinichiro Nakajima, Yoshihiro Noda
    • Journal Title

      Schizophrenia Research

      Volume: 252 Pages: 129-137

    • DOI

      10.1016/j.schres.2023.01.011

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Decreased Cortical Gyrification and Surface Area in the Left Medial Parietal Cortex in Patients with Treatment-Resistant and Ultra-Treatment-Resistant Schizophrenia2022

    • Author(s)
      Kazutoshi Kitajima, Shunsuke Tamura, Daiki Sasabayashi, et al.
    • Journal Title

      Psychiatry and Clinical Neurosciences

      Volume: 77 Issue: 1 Pages: 2-11

    • DOI

      10.1111/pcn.13482

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Multimodal imaging of the auditory-larynx motor network for voicing perception2022

    • Author(s)
      Shunsuke Tamura, Nobuyuki Hirose, Takako Mitsudo, Nobuhiko Hoaki, Itta Nakamura, Toshiaki Onitsuka, Yoji Hirano
    • Journal Title

      NeuroImage

      Volume: 251 Pages: 118981-118981

    • DOI

      10.1016/j.neuroimage.2022.118981

    • Related Report
      2022 Research-status Report 2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Recent findings on neurofeedback training for auditory hallucinations in schizophrenia2021

    • Author(s)
      Hirano Yoji*, Tamura Shunsuke
    • Journal Title

      Current Opinion in Psychiatry

      Volume: 34 Issue: 3 Pages: 245-252

    • DOI

      10.1097/yco.0000000000000693

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Oscillatory brain network changes after transcranial magnetic stimulation treatment in patients with major depressive disorder2021

    • Author(s)
      Ryo Mitoma, Shunsuke Tamura, Hiroshi Tateishi, Takako Mitsudo, Ichiro Tanabe, Akira Monji, Yoji Hirano*
    • Journal Title

      Journal of Affective Disorders Reports

      Volume: 7 Pages: 100277-100277

    • DOI

      10.1016/j.jadr.2021.100277

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Late responses in the anterior insula reflect the cognitive component of pain: evidence of non-pain processing2021

    • Author(s)
      Nami Taniguchi, Naruhito Hironaga, Takako Mitsudo, Shunsuke Tamura, Ken Yamaura, Shozo Tobimatsu
    • Journal Title

      PAIN Reports

      Volume: 7 Issue: 2 Pages: e984-e984

    • DOI

      10.1097/pr9.0000000000000984

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 統合失調症における自発γ振動の認知的制御不全:聴覚注意課題による検討2023

    • Author(s)
      光藤崇子, 田村俊介, 高井善史, 中西翔一郎, 上野雄文, 鬼塚俊明, 平野羊嗣
    • Organizer
      第53回日本臨床神経生理学会学術大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 統合失調症における内因性ガンマオシレーションの適応的な調整不全:聴覚注意課題による検討2023

    • Author(s)
      光藤崇子, 田村俊介, 高井善史, 中西翔一郎, 上野雄文, 鬼塚俊明, 平野羊嗣
    • Organizer
      第45回日本生物学的精神医学会年会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 急性の痒みモデルマウスにおけるオレキシンの関与2023

    • Author(s)
      金丸杏奈, 船橋英樹, 古郷央一郎, 内田ひなの, 治田彩香, 宮原裕, 田村俊介, 平野羊嗣, 西森利數, 石田康
    • Organizer
      第45回日本生物学的精神医学会年会
    • Related Report
      2023 Annual Research Report
  • [Presentation] マウス掻痒モデルの脳内c-Fos発現に対するL-DOPAくも膜下投与の効果2023

    • Author(s)
      内田ひなの, 古郷央一郎, 船橋英樹, 治田彩香, 金丸杏奈, 宮原裕, 田村俊介, 平野羊嗣, 西森利數, 石田康
    • Organizer
      第45回日本生物学的精神医学会年会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 統合失調症における音声誘発ガンマオシレーションの異常2023

    • Author(s)
      田村俊介, 高井善史, 光藤崇子, 中西翔一郎, 北島和俊, 三笘良, 鬼塚俊明, 平野羊嗣
    • Organizer
      第45回日本生物学的精神医学会年会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 治療抵抗性統合失調症および超治療抵抗性統合失調症患者における 左内側頭頂葉のGyrification低形成と表面積減少2023

    • Author(s)
      北島和俊, 田村俊介, 笹林大樹, 中島振一郎, 髙井善史, 髙橋潤一, 三村將, 平野昭吾, 中尾智博, 鬼塚俊明, Gary Remington, Ariel Graff-Guerrero, 平野羊嗣
    • Organizer
      第45回日本生物学的精神医学会年会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 統合失調症におけるメタ記憶障害に関するfMRI研究~症例検討による予備的検討~2023

    • Author(s)
      甲斐直路, 田村俊介, 高井善文, 榎本美奈, 光藤崇子, 平野昭吾, 宮田淳, 帆秋伸彦, 平野羊嗣, 中尾智博
    • Organizer
      第75回九州精神神経学会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 若年性ミオクロニーてんかんにおける聴性、および体性感覚性定常状態反応の異常2023

    • Author(s)
      三笘良, 田村俊介, 光藤崇子, 成儒彬, 松本航, 山口高弘, 向野隆彦, 重藤寛史, 平野羊嗣, 平野昭吾, 磯部紀子, 中尾智博
    • Organizer
      第56回日本てんかん学会学術総会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Altered information processing strategy among patients with schizophrenia in a liking task: an eye movement study2023

    • Author(s)
      Alexandra Wolf, Shunsuke Tamura, Takako Mitsudo, Kazuo Ueda, Yoji Hirano
    • Organizer
      The 39th Annual Meeting of the International Society for Psychophysics
    • Related Report
      2023 Annual Research Report
  • [Presentation] Effects of subanesthetic NMDA receptor antagonist on auditory steady-state response in common marmosets2023

    • Author(s)
      Naho Konoike, Shunsuke Tamura, Miki Miwa, Kumiko Mashita, Yoji Hirano, Kosuke Itoh, Katsuki Nakamura
    • Organizer
      11th IBRO World Congress of Neuroscience
    • Related Report
      2023 Annual Research Report
  • [Presentation] 発作性運動誘発性ジスキネジアにおける体性感覚定常反応課題時の皮質活動異常2023

    • Author(s)
      三笘良, 田村俊介, 成儒彬, 眞崎勝久, 平野昭吾, 中尾智博
    • Organizer
      第119回日本精神神経学会学術総会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 統合失調症のγオシレーション異常に関わる脳内ネットワークの検討2022

    • Author(s)
      鬼塚俊明, 田村俊介, 高井善文, 帆秋伸彦, 平野羊嗣
    • Organizer
      第118回日本精神神経学会学術総会
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] 統合失調症者における自発-聴覚関連課題間のγ帯域神経振動異常2022

    • Author(s)
      三笘良, 田村俊介, 成儒彬, 光藤崇子, 高井善文, 中村一太, 中尾 智博, 鬼塚 俊明, 平野 羊嗣
    • Organizer
      第118回 日本精神神経学会学術総会
    • Related Report
      2022 Research-status Report
  • [Presentation] Information processing abnormalities among patients with schizophrenia in a decision-making task2022

    • Author(s)
      Alexandra Wolf, Shunsuke Tamura, Takako Mitsudo, Kazuo Ueda, Yoji Hirano
    • Organizer
      The 38th Annual Meeting of the International Society for Psychophysics
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] A preliminary study on evaluative responses toward naturalistic food images among patients with schizophrenia and healthy controls2022

    • Author(s)
      Alexandra Wolf, Shunsuke Tamura, Takako Mitsudo, Kazuo Ueda, Yoji Hirano
    • Organizer
      European Conference on Visual Perception
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] 海馬回旋異常における構造的MRIの特徴の検討2022

    • Author(s)
      向野隆彦, 山口高弘, 岡留敏樹, 山田絵美, 太田真理, 三笘良, 光藤崇子, 田村俊介, 平野羊嗣, 栂尾理, 萩原綱一, 磯部紀子, 重藤寛史
    • Organizer
      第55回日本てんかん学会学術集会
    • Related Report
      2022 Research-status Report
  • [Presentation] The imaging characteristics of incomplete hippocampal inversion2022

    • Author(s)
      Takahiro Mukaino, Takahiro Yamaguchi, Toshiki Okadome, Emi Yamada, Shinri Ohta, Ryo Mitoma, Takako Mitsudo, Shunsuke Tamura, Yoji Hirano, Osamu Togao, Koichi Hagiwara, Noriko Isobe, Hiroshi Shigeto
    • Organizer
      14th Asian & Oceanian Epilepsy Congress
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] 治療抵抗性統合失調症における40Hz聴性刺激誘発脳波の検討2022

    • Author(s)
      尾久 守侑, 松下 佳鈴, 本多栞, 和田真孝, 田村俊介, 竹ノ内一雅, 戸張維, 楠戸恵介, 加藤英生, 小泉輝樹, 新井脩泰, 是木明宏, 松井三枝, 内田裕之, 藤井進也, 女屋光基, 平野羊嗣, 三村將, 中島振一郎, 野田 賀大
    • Organizer
      日本臨床神経生理学会第52回学術大会
    • Related Report
      2022 Research-status Report
  • [Presentation] 統合失調症における聴覚情報処理の脳内機構に関するfMRI研究2022

    • Author(s)
      高井善史, 田村俊介, 北島和俊, 帆秋伸彦, 鬼塚俊明, 平野羊嗣
    • Organizer
      第20回精神疾患と認知機能研究会
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Preliminary Study on Preference Formation under Two Different Tasks (Liking and Shopping) among Healthy Controls2021

    • Author(s)
      Alexandra Wolf, Shunsuke Tamura, Kazuo Ueda, Yoji Hirano
    • Organizer
      2021 Congress of the Schizophrenia International Research Society
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Attention to Sound Modulates Gamma Oscillation: Towards Neurofeedback Training2021

    • Author(s)
      Yoji Hirano, Shunsuke Tamura
    • Organizer
      2021 Congress of the Schizophrenia International Research Society
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Dynamic Neural Activity Changes After Transcranial Magnetic Stimulation Treatment in Patients With Major Depressive Disorder2021

    • Author(s)
      Yoji Hirano, Ryo Mitoma, Shunsuke Tamura, Hiroshi Tateishi, Akira Monji
    • Organizer
      Society of biological psychiatry 2021 virtual meeting
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] 音声の時間情報に同期する θ・γ帯域神経オシレーションの帯域間相互作用とその障害2021

    • Author(s)
      田村俊介, 光藤崇子, 平野羊嗣
    • Organizer
      日本音響学会 2021年秋季研究発表会
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] 音刺激への注意は背景γ活動を抑制させ刺激への同期度を高めるか2021

    • Author(s)
      光藤崇子, 田村俊介, 平野羊嗣
    • Organizer
      日本音響学会 2021年秋季研究発表会
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] 聴覚ミスマッチ検出におけるガンマオシレーションの役割2021

    • Author(s)
      田村俊介, 平野羊嗣, 光藤崇子, 鬼塚俊明
    • Organizer
      第51回日本臨床神経生理学会学術大会
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research

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Published: 2021-04-28   Modified: 2025-01-30  

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