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Spatiotemporal structure and rheological property of many body soft particle flow

Research Project

Project/Area Number 21K13891
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 13040:Biophysics, chemical physics and soft matter physics-related
Research InstitutionChiba University

Principal Investigator

Ito Hiroaki  千葉大学, 大学院理学研究院, 助教 (10783186)

Project Period (FY) 2021-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2023: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2022: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2021: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords懸濁液 / エマルション / マイクロ流路 / レオロジー / 流体相互作用 / 液滴 / 細胞 / マニピュレーション / 赤血球
Outline of Research at the Start

多数のやわらかい微粒子が流体に懸濁した系は、細胞懸濁液やエマルションなど、自然界から産業界にわたり普遍的に存在する。本研究では、これらの懸濁液の流動性を制御するための指針となる基礎的な流動原理の解明を目指す。このために、ミクロな懸濁粒子のダイナミクスを詳細に観察可能なマイクロ流体実験を行い、時間的・空間的に現れる特徴的な構造を解析する。さらに、マクロな溶液としての流れやすさとの対応づけを行う。

Outline of Final Research Achievements

In this study, we performed microfluidic experiments to elucidate the fundamental flow principles that guide the controllability of fluidity in soft particle suspension systems. Specifically, we investigated the flow of monodisperse water droplets in a continuous oil phase at various droplet densities using a quasi-two-dimensional microchannel with a thickness much shorter than its planar dimensions. As a result, we identified the spatial structure of deformation and the underlying mechanisms of droplet interactions in low and high density conditions. In low-density flows, hydrodynamic interactions, which are mediated by the flow field generated around each droplet, were dominant, whereas in high-density flows, contributions from hydrodynamic interactions and contact interactions with multiple droplets became dominant.

Academic Significance and Societal Importance of the Research Achievements

やわらかな粒子懸濁液系の流動特性を制御するための基礎的な流動原理を解明することで、様々な工学的応用や産業プロセスにおける流動制御の基礎的理解を深めたと言える。特に、低密度から高密度における液滴間の相互作用のメカニズムを明らかにしたことで、複雑流体系における物理現象の理解が進展した。また、マイクロ流路を用いた精密な実験を通じて、ミクロスケールでの流動特性を詳細に解析する技術の発展にも寄与しており、マイクロ流体技術の応用範囲を広げるための重要なステップである。これらの研究成果や技術発展は、化粧品、食品、医薬品などの分野で利用される懸濁液製造プロセスにおいて、品質向上や効率化にも資する可能性がある。

Report

(4 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • Research Products

    (29 results)

All 2024 2023 2022 2021 Other

All Int'l Joint Research (1 results) Journal Article (6 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 6 results,  Open Access: 2 results) Presentation (20 results) (of which Int'l Joint Research: 7 results,  Invited: 5 results) Remarks (2 results)

  • [Int'l Joint Research] Ljubljana University(スロベニア)

    • Related Report
      2023 Annual Research Report
  • [Journal Article] Lateral Transport of Domains in Anionic Lipid Bilayer Membranes under DC Electric Fields: A Coarse-Grained Molecular Dynamics Study2023

    • Author(s)
      Ito Hiroaki、Shimokawa Naofumi、Higuchi Yuji
    • Journal Title

      The Journal of Physical Chemistry B

      Volume: 127 Issue: 41 Pages: 8860-8868

    • DOI

      10.1021/acs.jpcb.3c04351

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Horizontal transport in the bouncing ball system with a sawtooth-shaped table2023

    • Author(s)
      Okishio Yudai、Ito Hiroaki、Kitahata Hiroyuki
    • Journal Title

      Physica D: Nonlinear Phenomena

      Volume: 453 Pages: 133754-133754

    • DOI

      10.1016/j.physd.2023.133754

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Coarse-grained molecular dynamics simulation of cation distribution profiles on negatively charged lipid membranes during phase separation2023

    • Author(s)
      Higuchi Yuji、Bohinc Klemen、Re??i? Jurij、Shimokawa Naofumi、Ito Hiroaki
    • Journal Title

      Soft Matter

      Volume: 19 Issue: 20 Pages: 3640-3651

    • DOI

      10.1039/d3sm00222e

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Two-dimensional hydrodynamic simulation for synchronization in coupled density oscillators2023

    • Author(s)
      Takeda Nana、Ito Hiroaki、Kitahata Hiroyuki
    • Journal Title

      Physical Review E

      Volume: 107 Issue: 3 Pages: 034201-034201

    • DOI

      10.1103/physreve.107.034201

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endocytosis-Like Vesicle Fission Mediated by a Membrane-Expanding Molecular Machine Enables Virus Encapsulation for In Vivo Delivery2023

    • Author(s)
      Uchida Noriyuki、Ryu Yunosuke、Takagi Yuichiro、Yoshizawa Ken、Suzuki Kotono、Anraku Yasutaka、Ajioka Itsuki、Shimokawa Naofumi、Takagi Masahiro、Hoshino Norihisa、Akutagawa Tomoyuki、Matsubara Teruhiko、Sato Toshinori、Higuchi Yuji、Ito Hiroaki、Morita Masamune、Muraoka Takahiro
    • Journal Title

      Journal of the American Chemical Society

      Volume: 145 Issue: 11 Pages: 6210-6220

    • DOI

      10.1021/jacs.2c12348

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fabrication of Microparticles with Front?Back Asymmetric Shapes Using Anisotropic Gelation2021

    • Author(s)
      Lee Dongkyu、Kitahata Hiroyuki、Ito Hiroaki
    • Journal Title

      Micromachines

      Volume: 12 Issue: 9 Pages: 1121-1121

    • DOI

      10.3390/mi12091121

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 荷電リン脂質膜-電解質系の自己組織化構造形成2024

    • Author(s)
      伊藤弘明
    • Organizer
      PF研究会「物質・生命研究における小角散乱法の展開:現状と展望のための討論会」
    • Related Report
      2023 Annual Research Report
  • [Presentation] マイクロ流体デバイスで測る赤血球細胞の膜物性・流動特性2024

    • Author(s)
      伊藤弘明
    • Organizer
      第6回生体膜デザインコンファレンス
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] Orientational patterns of deformable microdroplets under a quasi-two-dimensional flow2023

    • Author(s)
      H. Ito, Y. Arakawa, H. Kitahata
    • Organizer
      Advanced core-to-core network for the physics of self-organizing active matter
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Hydrodynamic ordering of deformable particles in a quasi-two-dimensional flow2023

    • Author(s)
      H. Ito, Y. Arakawa, H. Kitahata
    • Organizer
      International Soft Matter Conference 2023 (ISMC2023)
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Orientational order of deformable microparticles under a quasi-two-dimensional flow2023

    • Author(s)
      H. Ito
    • Organizer
      Japan-China Workshop on Bio-Soft Matter 2023
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Orientational order of deformable microdroplets under a quasi-two-dimensional flow2023

    • Author(s)
      H. Ito, Y. Arakawa, H. Kitahata
    • Organizer
      StatPhys28
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 粒子集団の擬2次元流れに現れる変形配向秩序2023

    • Author(s)
      伊藤弘明、荒川陽輔、北畑裕之
    • Organizer
      第11回ソフトマター研究会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 人工細胞膜における荷電脂質分子の相分離とドメイン輸送2023

    • Author(s)
      伊藤弘明、下川直史、樋口裕次
    • Organizer
      細胞を創る研究会16.0
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 擬2次元流れにおけるマイクロ液滴集団の変形配向秩序2023

    • Author(s)
      伊藤弘明、荒川陽輔、北畑裕之
    • Organizer
      日本物理学会第78回年次大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 楕円領域に拘束した上皮細胞の集団回転秩序2023

    • Author(s)
      佐藤慎一郎、北畑裕之、伊藤弘明
    • Organizer
      第22回関東ソフトマター研究会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 楕円領域に拘束した上皮細胞の集団運動2023

    • Author(s)
      佐藤慎一郎、北畑裕之、伊藤弘明
    • Organizer
      日本物理学会第78回年次大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] On-chip manipulation platform for deformability measurements of red blood cells2023

    • Author(s)
      Hiroaki Ito
    • Organizer
      8th Ajou-Chiba Joint Symposium
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 積層荷電リン脂質膜に対する低分子電解質の添加効果2022

    • Author(s)
      伊藤弘明、下川直史、樋口祐次、菱田真史
    • Organizer
      日本物理学会2022年秋季大会
    • Related Report
      2022 Research-status Report
  • [Presentation] 擬2次元流れにおけるマイクロ液滴集団の拡散運動2022

    • Author(s)
      荒川陽輔、伊藤弘明、北畑裕之
    • Organizer
      日本物理学会2022年秋季大会
    • Related Report
      2022 Research-status Report
  • [Presentation] 積層荷電リン脂質膜に対する電解質添加効果2022

    • Author(s)
      伊藤弘明、下川直史、樋口祐次、菱田真史
    • Organizer
      第73回コロイドおよび界面化学討論会
    • Related Report
      2022 Research-status Report
  • [Presentation] マイクロ液滴列に対する圧力変調印加による配置分布の制御2022

    • Author(s)
      小澤穣、北畑裕之、伊藤弘明
    • Organizer
      第73回コロイドおよび界面化学討論会
    • Related Report
      2022 Research-status Report
  • [Presentation] 擬2次元流れにおけるマイクロ液滴集団の運動と変形2022

    • Author(s)
      荒川陽輔、北畑裕之、伊藤弘明
    • Organizer
      第21回関東ソフトマター研究会
    • Related Report
      2022 Research-status Report
  • [Presentation] On-chip manipulation for revealing novel aspects of red blood cell mechanics2021

    • Author(s)
      Hiroaki Ito
    • Organizer
      ESCHM-ISCH-ISB 2021 FUKUOKA
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Fabrication of microparticles with front-back asymmetric shapes by droplet-based microfluidics2021

    • Author(s)
      Hiroaki Ito, Dongkyu Lee, Hiroyuki Kitahata
    • Organizer
      International Conference on Advanced Mechanism and Machine Technology 2021 (ICMMT 2021)
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] DC電場に駆動される荷電脂質相分離ドメインの粗視化シミュレーション2021

    • Author(s)
      伊藤弘明、下川直史、樋口祐次
    • Organizer
      日本物理学会2021年秋季大会
    • Related Report
      2021 Research-status Report
  • [Remarks] Hiroaki Ito

    • URL

      http://nonlinear.s.chiba-u.jp/~ito/

    • Related Report
      2023 Annual Research Report 2021 Research-status Report
  • [Remarks] researchgate

    • URL

      https://www.researchgate.net/profile/Hiroaki-Ito-6

    • Related Report
      2021 Research-status Report

URL: 

Published: 2021-04-28   Modified: 2025-01-30  

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