Computational design of recognition peptide based plasmonic biosensor for small molecules detection
| Project/Area Number |
21K14169
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 21030:Measurement engineering-related
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| Research Institution | Okayama University |
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Principal Investigator |
WANG JIN 岡山大学, ヘルスシステム統合科学学域, 准教授 (10870975)
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Project Status |
Completed (Fiscal Year 2023)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2023: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2022: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2021: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | peptide / drug molecule / computational design / small molecules / odorant binding protein / docking / organic receptors / 計算分子設計 / ペプチド / プラズモニック / がんやCOVID-19のVOCsバイオマーカー |
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| Outline of Research at the Start |
Peptide as a promising molecular recognition element has gained intense interest for developing novel sensing devices. In this study, rational design of peptide based plasmonic biosensor for small molecules (volatile organic compounds biomarkers from cancer/disease and COVID-19) will be developed.
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| Outline of Annual Research Achievements |
Small drug molecule, esculetin, are very important in adipose tissues, and regulates serum lipid profiles and shows potential anti-atherosclerosis benefits. In this stage, we use the computational design and molecular docking to simulate that the direct interaction between C/EBPβ and esculetin and conducted the research to clarify their reaction in vitro using optical sensor. These findings suggest that esculetin accelerates postprandial lipid circulation by binding to C/EBPβ and augmenting CD36-dependent phagocytosis in ATMs. The work was under review by Advanced Science. Furthermore, another novel designed peptide for TNT explosive was performed.
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Report
(3 results)
Research Products
(7 results)
