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Development of bright CPL molecules based on a novel molecular strategy and its biosensing application

Research Project

Project/Area Number 21K14601
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 32020:Functional solid state chemistry-related
Research InstitutionOsaka University

Principal Investigator

Shigemitsu Hajime  大阪大学, 大学院工学研究科, 講師 (00791815)

Project Period (FY) 2021-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2022: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2021: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords円偏光発光 / シクロデキストリン / 超分子化学 / エキシマー / ピレン / 分子センシング / 超分子 / バイオセンシング
Outline of Research at the Start

本研究では、環状分子や超分子を利用して『空間的に制限されたエキシマー』を生み出す独自の戦略によって、優れたCPL分子を創出する。環状分子や超分子を利用してピレンなどの発光団を複数修飾することで、立体的に混み合った状況を生み出し、優れたg値を有する示す傾向にある空間的に制限されたエキシマーを創り出し、CPL有機分子が抱えている課題の解決を目指す。

Outline of Final Research Achievements

Excellent CPL molecules using our original strategy of generating "spatially restricted excitons" using cyclic molecules (cyclodextrins, CyD) were successfully developed. By modifying multiple luminescent groups such as pyrene on the CyD ring, under molecular crowded situation, generating spatially restricted excimers and achieving excellent anisotropy in CPL. Furthermore, the CPL molecules created in this study can utilize their internal space as a recognition site for biomolecules, enabling pioneering CPL sensing of biomolecules.

Academic Significance and Societal Importance of the Research Achievements

本研究成果によって、新たに高輝度CPL分子が創出されるものと期待される。これらは、ディスプレイ、通信、情報処理等の様々な技術への応用が期待される。また、本研究で開発した分子は、ゲスト分子を内包することでCPL特性を大きく変化させることを明らかにした。これらの成果は、CPLバイオセンシングへの応用可能性を明確に示している。

Report

(3 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • Research Products

    (22 results)

All 2023 2022 2021

All Journal Article (8 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 8 results,  Open Access: 8 results) Presentation (13 results) (of which Int'l Joint Research: 4 results,  Invited: 12 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Fluorescein-Based Type I Supramolecular Photosensitizer via Induction of Charge Separation by Self-Assembly2022

    • Author(s)
      Shigemitsu Hajime、Ohkubo Kei、Sato Kazuhide、Bunno Asuka、Mori Tadashi、Osakada Yasuko、Fujitsuka Mamoru、Kida Toshiyuki
    • Journal Title

      JACS Au

      Volume: 2 Issue: 6 Pages: 1472-1478

    • DOI

      10.1021/jacsau.2c00243

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Amphiphilic Rhodamine Nano-assembly as a Type I Supramolecular Photosensitizer for Photodynamic Therapy2022

    • Author(s)
      Shigemitsu Hajime、Sato Kazuhide、Hagio Satomi、Tani Youhei、Mori Tadashi、Ohkubo Kei、Osakada Yasuko、Fujitsuka Mamoru、Kida Toshiyuki
    • Journal Title

      ACS Applied Nano Materials

      Volume: 5 Issue: 10 Pages: 14954-14960

    • DOI

      10.1021/acsanm.2c03192

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Porphyrin covalent organic nanodisks synthesized using acid-assisted exfoliation for improved bactericidal efficacy2022

    • Author(s)
      Li Xinxi、Shigemitsu Hajime、Goto Tomoyo、Kida Toshiyuki、Sekino Tohru、Fujitsuka Mamoru、Osakada Yasuko
    • Journal Title

      Nanoscale Advances

      Volume: 4 Issue: 14 Pages: 2992-2995

    • DOI

      10.1039/d2na00318j

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Visible Light-Induced Regio- and Enantiodifferentiating [2 + 2] Photocycloaddition of 1,4-Naphthoquinones Mediated by Oppositely Coordinating 1,3,2-Oxazaborolidine Chiral Lewis Acid2022

    • Author(s)
      Shimizu Nao、Shigemitsu Hajime、Kida Toshiyuki、Bach Thorsten、Mori Tadashi
    • Journal Title

      The Journal of Organic Chemistry

      Volume: 87 Issue: 12 Pages: 8071-8083

    • DOI

      10.1021/acs.joc.2c00730

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cyclodextrins with Multiple Pyrenyl Groups: An Approach to Organic Molecules Exhibiting Bright Excimer Circularly Polarized Luminescence2021

    • Author(s)
      Shigemitsu Hajime、Kawakami Kosei、Nagata Yuuya、Kajiwara Rikuo、Yamada Shintaro、Mori Tadashi、Kida Toshiyuki
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 61 Issue: 8

    • DOI

      10.1002/anie.202114700

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A cyanine dye based supramolecular photosensitizer enabling visible-light-driven organic reaction in water2021

    • Author(s)
      Shigemitsu Hajime、Tamemoto Tomoe、Ohkubo Kei、Mori Tadashi、Osakada Yasuko、Fujitsuka Mamoru、Kida Toshiyuki
    • Journal Title

      Chemical Communications

      Volume: 57 Issue: 85 Pages: 11217-11220

    • DOI

      10.1039/d1cc04685c

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Highly Regulated Supramolecular Assembly of 2-<i>O</i>-Methylated α-Cyclodextrin to Construct Vertically Oriented Microrods on Graphite2021

    • Author(s)
      Kalaw Justine M.、Kitagawa Mizuki、Shigemitsu Hajime、Kida Toshiyuki
    • Journal Title

      Langmuir

      Volume: - Issue: 17 Pages: 5149-5155

    • DOI

      10.1021/acs.langmuir.1c02238

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Terminal Trialkylsilyl Substituent Effect of Janus-type Molecular Tubes on the Inclusion of Unsaturated Fatty Acid Esters2021

    • Author(s)
      Kogame-Asahara Chizuru、Iguchi Hitomi、Honda Kenichiro、Shigemitsu Hajime、Kida Toshiyuki
    • Journal Title

      ACS Omega

      Volume: 6 Issue: 4 Pages: 3227-3231

    • DOI

      10.1021/acsomega.0c05672

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Development of CPL Molecules Employing Cyclodextrin and the Functions2023

    • Author(s)
      Hajime Shigemitsu
    • Organizer
      International CPL and CPEL Conference in Osaka, JAPAN (ICCC-2023)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 分子集積が誘起する光学特性を利用した有機機能材料の創製2023

    • Author(s)
      重光 孟
    • Organizer
      日本化学会第103春季年会(2023)
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 分子集積型の光増感剤による光線力学療法2023

    • Author(s)
      重光 孟
    • Organizer
      医工若手研究者交流会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 分子集合によって発現する光触媒機能とエネルギー・バイオ応用2023

    • Author(s)
      重光 孟
    • Organizer
      第2回テクノアリーナ フォトニクス・センシング工学グループ交流フォーラム
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Cyclodextrins with Multiple Pyrenyl Groups Exhibiting Bright Excimer Circularly Polarized Luminescence2022

    • Author(s)
      Hajime Shigemitsu
    • Organizer
      Japan Taiwan Bilateral Workshop on Nano-Science 2022
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Cyclodextrins with Multiple Pyrenyl Groups Exhibiting Bright Excimer Circularly Polarized Luminescence2022

    • Author(s)
      Hajime Shigemitsu
    • Organizer
      International CPL and CPEL Conference in Osaka, JAPAN (ICCC-2022)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 有機色素分子集合体の創発的光学特性とエネルギー・バイオ応用2022

    • Author(s)
      重光 孟
    • Organizer
      第15回超分子若手懇談会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 光エネルギー変換機能を有する分子集合体の構築と機能2022

    • Author(s)
      重光 孟
    • Organizer
      第71 回高分子討論会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] シクロデキストリンを基盤とした高輝度円偏光発光分子の創出2022

    • Author(s)
      重光 孟
    • Organizer
      第38回シクロデキストリンシンポジウム
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 有機色素分子の集合体形成による光触媒活性および円偏光発光特性の創発2022

    • Author(s)
      重光 孟
    • Organizer
      第43回光化学若手の会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 有機色素分子の集合体形成が誘起する光触媒機能と応用2022

    • Author(s)
      重光 孟
    • Organizer
      第71回高分子年次大会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Cyclodextrins with multiple pyrenyl groups exhibiting bright excimer circularly polarized luminescence2022

    • Author(s)
      Hajime Shigemtisu
    • Organizer
      ICCC-2022
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] シクロデキストリンを利用した円偏光発光色素の開発2021

    • Author(s)
      重光孟、川上晃聖、山田慎太郎、森直、木田敏之
    • Organizer
      第37回シクロデキストリンシンポジウム
    • Related Report
      2021 Research-status Report
  • [Patent(Industrial Property Rights)] 光触媒2023

    • Inventor(s)
      重光孟・木田敏之
    • Industrial Property Rights Holder
      重光孟・木田敏之
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2023-028793
    • Filing Date
      2023
    • Related Report
      2022 Annual Research Report

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Published: 2021-04-28   Modified: 2024-01-30  

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