| Project/Area Number |
21K14676
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 35020:Polymer materials-related
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| Research Institution | Hokkaido University |
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Principal Investigator |
Fan Hailong 北海道大学, 化学反応創成研究拠点, 特任准教授 (20897277)
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| Project Period (FY) |
2021-04-01 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2022: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2021: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | hydrogel / underwater adhesion / sequence-control / cation-pi interactions / embolic agent |
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| Outline of Research at the Start |
The development of adhesives that can achieve robust adhesion to various surfaces underwater is important, but it remains a major challenge in material science. We propose the development of underwater adhesives with outstanding performances by using polymers having specific functional groups and sequences that inspired by natural adhesive proteins. Meanwhile, the detailed polymerization mechanism and underwater adhesion mechanism will be studied.
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| Outline of Final Research Achievements |
We established a facile method to synthesize polymers from the same pair of monomers but the different average sequences and studied the effect of the monomer sequence on the properties of polymers and related hydrogel materials. We discovered that the hydrogels with adjacent cationic-aromatic sequences exhibited strong adhesion in saline water. In medical applications, we discovered that polymer bearing adjacent cationic/aromatic sequences could glue the blood components together, forming a blood gel through electrostatic interactions in the physiological environment, which can work as a liquid embolic agent. We published 6 SCI papers and submitted 1 patent.
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| Academic Significance and Societal Importance of the Research Achievements |
We revealed that the monomer sequence plays a crucial role in determining the network structures and properties of hydrogels.We developed a revolutionary waterborne embolic agent for endovascular embolization treatment, based on a novel concept.
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