| Project/Area Number |
21K14746
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
ジャー トニーズィ 東京工業大学, 地球生命研究所, 特任助教 (10800328)
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| Project Period (FY) |
2021-04-01 – 2023-03-31
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| Project Status |
Granted (Fiscal Year 2021)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2022: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2021: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | Origins of Life / Protocell / Prebiotic Chemistry / Astrobiology / Phase Separation |
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| Outline of Research at the Start |
Membraneless droplets generated by liquid-liquid phase separation (LLPS) were likely protocells. However, their structures and functions are unclear. We propose to study assembly, structure, and function of membraneless protocell compartments such as polyester droplets and liquid crystal coacervates. By probing the ability of LLPS protocells to stably compartmentalize and protect biomolecules and connecting these to essential modern cellular functions, we hope to understand more about how primitive protocells and chemistries directly evolved into modern cells and biologies.
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