| Project/Area Number |
21K14799
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 38050:Food sciences-related
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| Research Institution | Hokkaido University |
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Principal Investigator |
Chen Zhen 北海道大学, 保健科学研究院, 客員研究員 (60802634)
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| Project Period (FY) |
2021-04-01 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2022: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2021: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | Phytosterols / Seaweeds / Alzheimer’s disease / Nerrve cells / Lipid metabolism / Quantitative analysis / Quantitative an alysis / Phytosterol / Seaweed / Nerve cells / Quantitation / Extraction / NMR / phytosterols / seaweeds / neuronal cells / lipid metabolism |
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| Outline of Research at the Start |
In this proposal, phytosterol constituents will be isolated from edible seaweeds. Then, they will be evaluated for anti-Alzheimer bioactivities via lipid metabolism regulation based on in-vitro model. Next, phytosterol profiles in various dietary seaweeds will be analyzed to discover their characteristics. Furthermore, the discovered anti-Alzheimer functional phytosterols will be determined in seaweeds to hunt for dietary anti-Alzheimer phytosterol resources.
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| Outline of Final Research Achievements |
Alzheimer’s disease (AD) is a serious neurodegenerative disease involved in lipid metabolism disorder, while phytosterols are potential anti-AD components via regulating lipid metabolism. Although terrestrial phytosterols are well studied, marine phytosterols of seaweeds have been ignored for long. In this study, phytosterols were extracted and purified from edible seaweeds using the optimized procedure. Then, they were evaluated for anti-AD bioactivities via lipid metabolism regulation based on nerve cell model. Next, phytosterols in various dietary seaweeds were profiled and determined for exploring the dietary anti-AD phytosterol resources. This study not only developed marine phytosterols as new anti-AD functional components from foods, but also contribute to a better understanding of health-beneficial seaweed resources.
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| Academic Significance and Societal Importance of the Research Achievements |
It is first time to evaluate marine phytosterols for their anti-AD bioactivity via lipid metabolism, and first time to prepare phytosterols from seaweeds with method optimization, as well as quantitative profiling. This study developed marine phytosterols as new anti-AD functional food components.
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