カルノシンの骨格筋再生における生理的役割の解明、および応用
| Project/Area Number |
21K14804
|
|---|
| Research Category |
Grant-in-Aid for Early-Career Scientists
|
| Allocation Type | Multi-year Fund |
|---|
| Review Section |
Basic Section 38050:Food sciences-related
|
|---|
| Research Institution | Hiroshima University |
|---|
Principal Investigator |
KUMRUNGSEE THANUTCHAPORN (カムランシー タナッチャポーン) 広島大学, 統合生命科学研究科(生), 准教授 (90781849)
|
|---|
| Project Period (FY) |
2021-04-01 – 2024-03-31
|
| Project Status |
Completed (Fiscal Year 2023)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2023: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2022: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
|---|
| Keywords | Carnosine / Muscle regeneration / Skeletal muscle / Vitamin B6 / sarcopenia / dexamethasone / Satellite cells / Twist2 |
|---|
| Outline of Research at the Start |
For decades, carnosine has been believed to improve exercise performance and prevent sarcopenia, but its exact molecular mechanisms remain unknown. This study aims to clarify if carnosine has any effects on muscle satellite cells (SCs, Pax7+ cells) and recently identified muscle progenitor cells (PCs, Tw2+ cells), essential for skeletal muscle regeneration and maintaining muscle mass, respectively. Moreover, this study will determine how carnosine plays a role in muscle regeneration and muscle energy metabolism.
|
| Outline of Annual Research Achievements |
In FY2023, effects of vitamin B6 on satellite cell activity and muscle atrophy have been examined. As a results, a vitamin B6 deficient diet exhibited a significant decrease in the quiescent satellite cell (SC) pool in mouse muscles, as compared to the vitamin B6 supplemented diet. By the single myofiber culture experiment, vitamin B6 deficiency suppressed the proliferation and self-renewal of SCs during myogenesis. In the dexamethasone-induce muscle atrophy model, we found that vitamin B6 deficiency aggravated muscle atrophy, while vitamin B6 supplementation attenuated muscle atrophy. Vitamin B6 supplementation significantly suppressed the up-regulation of Murf-1 and Atrogin-1 expressions in muscles, suggesting that vitamin B6 possibly attenuated muscle atrophy via preventing muscle degradation.
|
Report
(3 results)
Research Products
(40 results)
-
-
-
-
[Journal Article] Exogenous Penicillium camemberti Lipase Preparation Exerts Prebiotic-like Effects by Increasing Cecal Bifidobacterium and Lactobacillus Abundance in Rats2023
Author(s)
Yongshou Yang, Huijuan Jia, Chika Ando, Hisanori Kato*, Thanutchaporn Kumrungsee*, Norihisa Kato, Akiko Kimoto, Shinji Fukuda, Manabu Kuroda, Kyoichi Nishio, and Shotaro Yamaguchi
-
Journal Title
Fermentation
Volume: 9
Issue: 3
Pages: 227-227
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
