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Discovery of environment friendly antifouling secondary metabolites to create new fishing net

Research Project

Project/Area Number 21K14904
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 40030:Aquatic bioproduction science-related
Research InstitutionShizuoka Institute of Science and Technology

Principal Investigator

Takashi Kamada  静岡理工科大学, 理工学部, 准教授 (40815859)

Project Period (FY) 2021-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2023: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2022: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2021: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords紅藻 / ソゾ / 二次代謝産物 / 含ハロゲン化合物 / テルペン / イガイ / 着生阻害 / 養殖網 / ソフトコーラル / 紅藻ソゾ / 汚損生物 / ムラサキイガイ / 環境対応型 / 防汚網 / 軟体サンゴ / 付着阻害 / 抗寄生虫
Outline of Research at the Start

海洋生物は種に応じ、特異的な生物活性を示す化合物を生産する。中でも紅藻は、塩素や臭素などのハロゲン原子を有する低分子有機化合物を蓄積することで、外敵から身を守る化学防御機構を備えている。本研究では、この防御機構に着目し、『紅藻由来の含ハロゲン化合物は、防汚性を備えた環境対応型の防汚網となり得るか』という問いに対し、次の二点を解決する。
(1)静岡県沿岸にて採集した紅藻類などから、汚損生物へ阻害活性を示す新しい候補化合物を見出すこと
(2)候補化合物をハイドロゲル高分子材料に混ぜて、海洋環境にやさしい防汚網の試作品を開発すること
本研究成果から、汚損生物に対する防汚網創製へ向けて重要な知見を得る。

Outline of Final Research Achievements

Secondary metabolites from red algae, marine mollusks, liverworts, and plants were evaluated for their antifouling activities on mussel tarsal filaments. Significant activity was observed for the terpenes from red algae and mollusks. Examination of the structure-activity relationship revealed that the presence or absence of halogen atoms is likely to play a significant role in the activity.
To develop a new environmentally friendly aquaculture net, I constructed a hydrogel layer on a commercially available net and examined whether it was possible to internalize marine terpenes. The results showed that the compatibility of the hydrogel polymeric agent with nets made of Tetoron was excellent and that it was possible to internalize low-molecular-weight compounds in the polymeric agent.

Academic Significance and Societal Importance of the Research Achievements

研究を推進し、農林水産省気候変動適応計画の目標項目に挙げられる「魚病への対策を講じること」と世界の定めるSDGs(持続可能な開発目標)の理念の一つである「海の豊かさを守ろう(14番)」に応えた。
本成果をマリンオープンイノベーション機構が主催したMaOIサロンで市民に広く紹介した。また「ひらめき☆ときめきサイエンス」に3年連続採択されており、児童の知的創造性を育む教育活動に積極的に参画した。

Report

(4 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • Research Products

    (36 results)

All 2024 2023 2022 2021 Other

All Int'l Joint Research (3 results) Journal Article (13 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 12 results,  Open Access: 3 results) Presentation (19 results) (of which Int'l Joint Research: 4 results,  Invited: 1 results) Patent(Industrial Property Rights) (1 results)

  • [Int'l Joint Research] Latvian Institute of Organic Synthesis(ラトビア)

    • Related Report
      2023 Annual Research Report
  • [Int'l Joint Research] National University of Singapore(シンガポール)

    • Related Report
      2021 Research-status Report
  • [Int'l Joint Research] University of Malaysia Sabah(マレーシア)

    • Related Report
      2021 Research-status Report
  • [Journal Article] Halogenated Cyclic Monoterpenoids with Anti‐Biofouling Activity from the Okinawan Red Marine Algae Portieria Hornemannii2024

    • Author(s)
      Ishigami Shinnosuke、Fukada Ryosuke、Nagasaka Genki、Tsuruta Tomoki、Nishikawa Keisuke、Sasaki Yu、Nimura Kazumi、Oshima Iori、Yamagishi Yukimasa、Morimoto Yoshiki、Kamada Takashi、Ishii Takahiro
    • Journal Title

      Chemistry & Biodiversity

      Volume: - Issue: 5

    • DOI

      10.1002/cbdv.202400436

    • Related Report
      2023 Annual Research Report
  • [Journal Article] New Marine Diterpenoid from the Okinawan Soft Coral, Lobophytum sp.2023

    • Author(s)
      Sato Kosuke、Ishigami Shinnosuke、Koike Masaki、Takegahara Haruto、Yamamoto Ayumi、Kaneko Kensuke、Tani Kazuki、Ishii Takahiro、Kamada Takashi
    • Journal Title

      Natural Product Communications

      Volume: 18 Issue: 1 Pages: 1-6

    • DOI

      10.1177/1934578x221075978

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Diversity of Halogenated Secondary Metabolites in Okinawan Aplysia argus Including 12‐Hydroxypinnaterpene C and Their Feeding Targets2023

    • Author(s)
      Nagasaka Misaki、Isa Hayato、Tahara Arisu、Fukada Ryosuke、Kamada Takashi、Ishii Takahiro
    • Journal Title

      Chemistry & Biodiversity

      Volume: 20 Issue: 8

    • DOI

      10.1002/cbdv.202300791

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Front Cover: Diversity of Halogenated Secondary Metabolites in Okinawan Aplysia argus Including 12‐Hydroxypinnaterpene C and Their Feeding Targets (Chem. Biodiversity 8/2023)2023

    • Author(s)
      Nagasaka Misaki、Isa Hayato、Tahara Arisu、Fukada Ryosuke、Kamada Takashi、Ishii Takahiro
    • Journal Title

      Chemistry & Biodiversity

      Volume: 20 Issue: 8

    • DOI

      10.1002/cbdv.202301226

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Antifouling Brominated Diterpenoids from Japanese Marine Red Alga Laurencia venusta Yamada2023

    • Author(s)
      Fukada Ryosuke、Yamagishi Yukimasa、Nagasaka Misaki、Osada Daiki、Nimura Kazumi、Oshima Iori、Tsujimoto Kazuki、Kirihara Masayuki、Takizawa Shinobu、Kikuchi Norio、Ishii Takahiro、Kamada Takashi
    • Journal Title

      Chemistry Biodiversity

      Volume: 20 Issue: 8

    • DOI

      10.1002/cbdv.202300888

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diterpene Glycosides Derived from Aster spathulifolius Have Immunomodulatory Effects2023

    • Author(s)
      Kawano Jin、Fukada Ryosuke、Sato Kosuke、Kitajima Atsuhito、Kirihara Masayuki、Tsuge Keisuke、Kumeta Mayu、Hara Takuya、Hashimoto Hitoshi、Tani Koji、Kamada Takashi
    • Journal Title

      HETEROCYCLES

      Volume: 106 Issue: 12 Pages: 2040-2040

    • DOI

      10.3987/com-23-14919

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two New Eremophilane‐Type Sesquiterpenoids from Japanese Liverwort <i>Bazzania japonica</i>2023

    • Author(s)
      Fukada Ryosuke、Kawano Jin、Tsuruta Tomoki、Nonaka Takuto、Sato Kosuke、Miyajima Susumu、Ishigami Shinnosuke、Ishii Takahiro、Nishikawa Keisuke、Asakawa Yoshinori、Kamada Takashi
    • Journal Title

      Chemistry & Biodiversity

      Volume: 20 Issue: 4 Pages: 1-1

    • DOI

      10.1002/cbdv.202300131

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Front Cover: Two New Eremophilane‐Type Sesquiterpenoids from Japanese Liverwort <i>Bazzania japonica</i> (Chem. Biodiversity 4/2023)2023

    • Author(s)
      Fukada Ryosuke、Kawano Jin、Tsuruta Tomoki、Nonaka Takuto、Sato Kosuke、Miyajima Susumu、Ishigami Shinnosuke、Ishii Takahiro、Nishikawa Keisuke、Asakawa Yoshinori、Kamada Takashi
    • Journal Title

      Chemistry & Biodiversity

      Volume: 20 Issue: 4 Pages: 1-1

    • DOI

      10.1002/cbdv.202300485

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Corrigendum: Two New Halogenated Compounds from the Marine Red Alga <i>Laurencia nipponica</i> Yamada from the Kunashiri and Etorofu Islands2022

    • Author(s)
      Sato Kosuke、Kaneko Kensuke、Kamekawa Tsuyoshi、Taba Kanako、Ishigami Shinnosuke、Wada Masahiro、Ishii Takahiro、Abe Tsuyoshi、Kamada Takashi、Suzuki Minoru
    • Journal Title

      Chemistry & Biodiversity

      Volume: 19 Issue: 3

    • DOI

      10.1002/cbdv.202200112

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Two New Abietane Diterpenoids from Plectranthus barbatus2022

    • Author(s)
      Ishii Takahiro、Matayoshi Natsuki、Taba Kanako、Kamada Takashi
    • Journal Title

      Chemistry of Natural Compounds

      Volume: 58 Pages: 474-477

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Unusual Cembrane Diterpenoid Isolated from the Japanese Soft Coral Genus Sinularia2022

    • Author(s)
      Ishii Takahiro、Sato Kosuke、Ito Ginji、Kawano Jin、Takabe Wakako、Phan Chin-Soon、Ishigami Shinnosuke、Kamada Takashi
    • Journal Title

      HETEROCYCLES

      Volume: 104 Issue: 4 Pages: 797-797

    • DOI

      10.3987/com-21-14613

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] New acetogenin katsuurallene from Laurencia saitoi collected from Katsuura, Japan2022

    • Author(s)
      Minamida Yu、Matsuura Hiroshi、Ishii Takahiro、Miyagi Miyu、Shinjo Yuto、Sato Kosuke、Kamada Takashi、Mihara Yoshihiro、Togashi Iwao、Sugimoto Keisuke、Abe Tsuyoshi、Kikuchi Norio、Suzuki Minoru
    • Journal Title

      Natural Products and Bioprospecting

      Volume: 12 Issue: 1

    • DOI

      10.1007/s13659-022-00328-1

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Two New Halogenated Compounds from the Marine Red Alga Laurencia nipponica Yamada from the Kunashiri and Etorofu Islands2021

    • Author(s)
      Sato Kosuke、Kaneko Kensuke、Kamekawa Tsuyoshi、Taba Kanako、Ishigami Shinnosuke、Wada Masahiro、Ishii Takahiro、Abe Tsuyoshi、Kamada Takashi、Suzuki Minoru
    • Journal Title

      Chemistry & Biodiversity

      Volume: 18 Issue: 9

    • DOI

      10.1002/cbdv.202100397

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Presentation] 沖縄産紅藻ソゾ属Laurenciaの分子系統解析2024

    • Author(s)
      山岸幸正・祝しずく・神崎涼菜・石井貴広・鎌田昂・三輪泰彦
    • Organizer
      日本藻類学会第48回大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] New antifouling brominated diterpenes from Japanese red alga genus Laurencia.2024

    • Author(s)
      Fukada, R., Nishikawa, K., Nimura, K., Oshima, I., Kirihara, M., Takizawa, S., Morimoto, Y., Yamagishi, Y., Kikuchi, N., Ishii, T., Kamada, T.
    • Organizer
      The 9th Asian Pacific Phycological Forum
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] New halogenated cyclic monoterpenoid with anti-biofouling activity from Japanese red alga Portieria hornemanni.2024

    • Author(s)
      Ishigami, S., Fukada, R., Nagasaka, G., Tsuruta, T., Nishikawa, K., Sasaki, Y., Nimura, K., Oshima, I., Yamagishi, Y., Morimoto, Y., Kamada, T., Ishii, T.
    • Organizer
      The 9th Asian Pacific Phycological Forum
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Chemotaxonomic study of Japanese marine red alga Laurencia composita.2024

    • Author(s)
      Miwa, T., Osada, D., Sato, K., Yamagishi, Y., Ishii, T., Kamada, T.
    • Organizer
      The 9th Asian Pacific Phycological Forum
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 沖縄県産軟体サンゴの化学防御機構に着目した抗マリングロス活性物質の探索2023

    • Author(s)
      石上慎之甫・鈴木綾乃・八木郁哉・高田晃瑠・川野仁・二村和視・大島伊織・鎌田昂・石井貴広
    • Organizer
      第67回香料・テルペンおよび精油化学に関する討論会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 日本産紅藻ヒメソゾ由来の新規含臭素ジテルペンの構造とムラサキイガイ着生阻害活性2023

    • Author(s)
      深田崚介・山岸幸正・長坂弥咲・長田大輝・二村和視・大島伊織・辻本夏月・桐原正之・滝澤忍・菊地則雄・石井貴広・鎌田昂
    • Organizer
      第67回香料・テルペンおよび精油化学に関する討論会
    • Related Report
      2023 Annual Research Report
  • [Presentation] SDGs対応型の新規漁網開発を目的とした着生阻害物質の探索2023

    • Author(s)
      長田大輝・佐藤光将・二村和視・大島伊織・小土橋陽平・鎌田昂
    • Organizer
      第67回香料・テルペンおよび精油化学に関する討論会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 海洋生物由来化合物のTK6細胞に対する細胞毒性・遺伝毒性評価2023

    • Author(s)
      竹ケ原陽斗・鎌田昂・加藤亜記・金子賢介・山本歩
    • Organizer
      日本農芸化学会2023年度大会
    • Related Report
      2022 Research-status Report
  • [Presentation] 日本産紅藻ソゾ属LaurenciaのrbcLおよびcox1系統解析2023

    • Author(s)
      山岸幸正・岡本修弥・菊池啓人・岸本直人・鎌田昂・菊池則雄・鈴木稔・三輪泰彦
    • Organizer
      日本藻類学会第47回大会
    • Related Report
      2022 Research-status Report
  • [Presentation] ダルマギク抽出物の免疫機能調節作用に関する研究2022

    • Author(s)
      谷孝二・川野仁・佐藤光将・原卓也・粂田麻由・橋本仁志・柘植圭介・鎌田昂
    • Organizer
      日本生薬学会第68回年会
    • Related Report
      2022 Research-status Report
  • [Presentation] 静岡県産ムチゴケ類が生産するテルペン類の化学構造と生物活性2022

    • Author(s)
      深田崚介・川野仁・野中拓渡・佐藤光将・石上慎之甫・石井貴広・浅川義範・鎌田昂
    • Organizer
      第66回香料・テルペンおよび精油化学に関する討論会
    • Related Report
      2022 Research-status Report
  • [Presentation] ダルマギク由来新規ジテルペンの探索と免疫調節作用2022

    • Author(s)
      川野仁・佐藤光将・谷孝二・原卓也・粂田麻由・橋本仁志・柘植圭介・鎌田昂
    • Organizer
      第66回香料・テルペンおよび精油化学に関する討論会
    • Related Report
      2022 Research-status Report
  • [Presentation] 与勝諸島に生育する紅藻ソゾ由来の新規二次代謝産物2022

    • Author(s)
      田原愛里寿・石上慎之甫・長坂弥咲・鎌田昂・石井貴広
    • Organizer
      第66回香料・テルペンおよび精油化学に関する討論会
    • Related Report
      2022 Research-status Report
  • [Presentation] 沖縄県産の軟体サンゴから得られた新規骨格を有するジテルペンの化学構造と生物活性2022

    • Author(s)
      石上慎之甫・佐藤光将・伊藤銀志・川野仁・髙部稚子・鎌田昂・石井貴広
    • Organizer
      第66回香料・テルペンおよび精油化学に関する討論会
    • Related Report
      2022 Research-status Report
  • [Presentation] ダルマギク抽出物の免疫調節作用と活性成分の探索2022

    • Author(s)
      谷孝二・川野仁・佐藤光将・原卓也・粂田麻由・橋本仁志・柘植圭介・鎌田昂
    • Organizer
      日本薬学会第142年会
    • Related Report
      2021 Research-status Report
  • [Presentation] 広島県東部海岸に生育する紅藻ソゾ属の分類について2022

    • Author(s)
      山岸幸正・弘岡瑞樹・米須夏美・佐藤将光・鎌田昂・菊池則雄・鈴木稔・阿部剛史・三輪泰彦
    • Organizer
      日本藻類学会第46回大会
    • Related Report
      2021 Research-status Report
  • [Presentation] Biological potentials of halogenated secondary metabolites from Japanese marine red algae Laurencia spp.2021

    • Author(s)
      Kamada Takashi、Sato Kosuke、Nimura Kazumi、Okamoto Kazutoshi
    • Organizer
      AFOB Malaysia Chapter International Symposium 2021
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 紅藻ソゾ由来の新規含ハロゲンテルペンの構造と生物活性2021

    • Author(s)
      佐藤光将・金子賢介・石井貴広・山岸幸正・加藤亜紀・二村和視・岡本一利・菊池則夫・鈴木稔・鎌田昂
    • Organizer
      第65回香料・テルペンおよび精油化学に関する討論会
    • Related Report
      2021 Research-status Report
  • [Presentation] Serratia nematodiphila H-1-1株の産生するミミズ殺傷物質2021

    • Author(s)
      趙浴竹・佐藤光将・鎌田昂・宮地竜郎
    • Organizer
      日本防菌防黴学会第48回年次大会
    • Related Report
      2021 Research-status Report
  • [Patent(Industrial Property Rights)] CD39発現促進剤2022

    • Inventor(s)
      粂田麻由、鎌田 昂、他5名
    • Industrial Property Rights Holder
      粂田麻由、原卓也、橋本仁志、谷孝二
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2022-029423
    • Filing Date
      2022
    • Related Report
      2021 Research-status Report

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Published: 2021-04-28   Modified: 2025-01-30  

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