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Demonstration of the vertebrate CMP-sialic acid synthetase as a novel regulatory protein of neural cell apoptosis

Research Project

Project/Area Number 21K15040
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 43030:Functional biochemistry-related
Research InstitutionNagoya University

Principal Investigator

呉 迪  名古屋大学, 生物機能開発利用研究センター, 助教 (10817547)

Project Period (FY) 2021-04-01 – 2023-03-31
Project Status Granted (Fiscal Year 2021)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2022: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2021: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
KeywordsSia-glycoconjugates / medaka fish / neurogenesis
Outline of Research at the Start

CMP-sialic acid synthetase (CSS) is a key enzyme for the expression of Sia-Glycolconjugates on the cell surface. Our previous results suggest that CSS plays a critical role in neurogenesis, not only as a sialylation-involved enzyme but also as an apoptosis-related protein. To clarify how CSS regulates the neural cell apoptosis: (1) To identify protein X by the proximity labeling technique; (2) To characterize the interaction between protein X and CSS at the molecular level; (3) To clarify the significance of the protein X-CSS interaction at the animal level using medaka model.

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Published: 2021-04-28   Modified: 2021-08-30  

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