Research Project
Grant-in-Aid for Early-Career Scientists
CMP-sialic acid synthetase (CSS) is a key enzyme for the expression of Sia-Glycolconjugates on the cell surface. Our previous results suggest that CSS plays a critical role in neurogenesis, not only as a sialylation-involved enzyme but also as an apoptosis-related protein. To clarify how CSS regulates the neural cell apoptosis: (1) To identify protein X by the proximity labeling technique; (2) To characterize the interaction between protein X and CSS at the molecular level; (3) To clarify the significance of the protein X-CSS interaction at the animal level using medaka model.