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Evolutionary Dynamics of Mutation Rates and their Driving Factors in Intracellular Symbiotic Bacteria

Research Project

Project/Area Number 21K15071
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 43050:Genome biology-related
Research InstitutionOkinawa International University (2022)
Okinawa Institute of Science and Technology Graduate University (2021)

Principal Investigator

Kinjo Yukihiro  沖縄国際大学, 経済学部, 研究員 (40865515)

Project Period (FY) 2021-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2022: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2021: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsゲノム進化 / 細胞内共生細菌 / 突然変異率 / 細胞内共生 / ゲノム縮小進化
Outline of Research at the Start

突然変異率は、進化生物学における各種理論の最も基本的なパラメータの一つであり、様々な進化過程に密接に関わるだけでなく、遺伝医学や育種学、さらには病原体の病毒性の進化など、様々な応用分野においても極めて重要である。しかしながら、突然変異率それ自体の進化がどのような要因に駆動されるのかは不明な点が多い。本研究では、突然変異率の新たな進化理論の足がかりとして、変異率の劇的な増減が報告されている昆虫の細胞内共生細菌を対象に、突然変異率の進化を駆動しうる諸要因とその進化動態について調査する。

Outline of Final Research Achievements

The mutation rate is an important and fundamental parameter closely related to many evolutionary processes. However, the driving factors behind the evolution of mutation rates remain largely unknown. Current theories on the evolution of mutation rates assume an evolutionary steady state within the organisms of interest, which hinders the prediction of the dynamic evolutionary processes of mutation rates in response to ecological changes. In this study, we investigated the driving factors and evolutionary dynamics of mutation rates in endosymbiotic bacteria of aphids to provide a promising framework for a new evolutionary theory of mutation rates.

Academic Significance and Societal Importance of the Research Achievements

突然変異率は、進化生物学における各種理論の最も基本的なパラメータの一つであり、様々な進化過程に密接に関わるだけでなく、遺伝医学や育種学、さらには病原体の病毒性の進化など、様々な応用分野においても極めて重要である。近年の次世代シーケンス技術の発展により、今後はさらに多くの環境・生態系においてゲノム情報を用いた研究の進展が予想される。本研究により得られるた知見は、そのようなゲノム情報を利用した進化生態学の研究領域において、その進化過程の解釈や予測に対し有益な洞察を与えることが期待される。

Report

(3 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • Research Products

    (8 results)

All 2023 2022 2021 Other

All Int'l Joint Research (1 results) Journal Article (3 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (4 results) (of which Invited: 1 results)

  • [Int'l Joint Research] シドニー大学(オーストラリア)

    • Related Report
      2022 Annual Research Report
  • [Journal Article] Coevolution of Metabolic Pathways in Blattodea and Their Blattabacterium Endosymbionts, and Comparisons with Other Insect-Bacteria Symbioses2022

    • Author(s)
      Kinjo Yukihiro、Bourguignon Thomas、Hongoh Yuichi、Lo Nathan、Tokuda Gaku、Ohkuma Moriya
    • Journal Title

      Microbiology Spectrum

      Volume: 10 Issue: 5 Pages: 02779-22

    • DOI

      10.1128/spectrum.02779-22

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The functional evolution of termite gut microbiota2022

    • Author(s)
      Arora Jigyasa、Kinjo Yukihiro、Sobotnik Jan、Bucek Ales、Clitheroe Crystal、Stiblik Petr、Roisin Yves、Zifcakova Lucia、Park Yung Chul、Kim Ki Yoon、Sillam-Dusses David、Herve Vincent、Lo Nathan、Tokuda Gaku、Brune Andreas、Bourguignon Thomas
    • Journal Title

      Microbiome

      Volume: 10 Issue: 1 Pages: 78-78

    • DOI

      10.1186/s40168-022-01258-3

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Enhanced Mutation Rate, Relaxed Selection, and the “Domino Effect” are associated with Gene Loss in Blattabacterium, A Cockroach Endosymbiont2021

    • Author(s)
      Kinjo Yukihiro、Lo Nathan、Martin Paula Villa、Tokuda Gaku、Pigolotti Simone、Bourguignon Thomas
    • Journal Title

      Molecular Biology and Evolution

      Volume: 38 Issue: 9 Pages: 3820-3831

    • DOI

      10.1093/molbev/msab159

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] ゲノム縮小進化過程における遺伝的浮動の影響に関する網羅的調査2023

    • Author(s)
      金城幸宏
    • Organizer
      日本ゲノム微生物学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 共生細菌におけるゲノム縮小の進化動態と分子進化パラメータの推定バイアス2022

    • Author(s)
      金城幸宏
    • Organizer
      日本微生物生体学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Three mechanisms driving reductive genome evolution of Blattabacterium, the endosymbiont of cockroaches2022

    • Author(s)
      金城幸宏・Thomas Bourguignon
    • Organizer
      第16回日本ゲノム微生物学会年会
    • Related Report
      2021 Research-status Report
  • [Presentation] ゴキブリの細胞内共生細菌Blattabacteriumの紹介とそのゲノム進化について2021

    • Author(s)
      金城幸宏
    • Organizer
      日本昆虫学会第81回大会
    • Related Report
      2021 Research-status Report
    • Invited

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Published: 2021-04-28   Modified: 2025-01-30  

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