| Project/Area Number |
21K15184
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 46010:Neuroscience-general-related
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Project Status |
Completed (Fiscal Year 2023)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2023: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2022: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2021: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | Basal ganglia / Striatum / Dopamine / Decision making / Nigrostriatal system / Dorsal striatum / Motor control / Reinforcement learning / Basal Ganglia / Goal-directed behavior / dLight / Goal directed behavior |
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| Outline of Research at the Start |
We will investigate the differential changes of the activity of the DMS and DLS projecting SNc dopaminergic neurons in rats performing a probabilistic reward based task. Also, we will elucidate the dopamine dynamics of local dopamine release into the DMS and DLS during the reward-based task.
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| Outline of Final Research Achievements |
We aimed to understand how the brain integrates past reward information to influence future actions, focusing on the nigrostriatal pathway. This pathway involves the SNc and the dorsal striatum, crucial for reward processing. We trained rats to perform a task where they chose one action which is more likely to result in a reward based on recent outcomes. Monitoring the neuronal activity in the SNc and dorsal striatum, we found that reward expectation significantly enhances the activity of neurons involved in movement. Our findings showed that the brain processes past rewards to guide future actions effectively, suggesting behaviors are optimized for obtaining rewards. This has important implications for developing treatments for movement and decision-making disorders. Demonstrating that reward expectations modulate the activity of neurons involved in movement and decision-making, contributing to the understanding of how the brain integrates reward information to influence behavior.
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| Academic Significance and Societal Importance of the Research Achievements |
この研究は、脳が過去の報酬情報をどのように統合して将来の行動を導くかを探求しました。結果、報酬の期待が運動に関与するニューロンの活動を大幅に高めることを発見しました。これは、パーキンソン病や依存症など、意思決定や運動に影響を与える疾患の治療法開発において重要です。
脳がどのようにして報酬情報を処理し、行動を最適化するかの基本的なメカニズムについての洞察を提供します。社会的には、これらの知見は神経疾患の治療法改善につながり、影響を受けた人々の生活の質を向上させる可能性があります。報酬の期待が脳活動に与える影響を明らかにすることで、脳機能に関する知識を広げ、医学や社会への応用に貢献します。
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