| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2022: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2021: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Outline of Final Research Achievements |
We examined the concentration of inflammation-related mediators in glioblastoma(GBM) patients' cerebrospinal fluid and examined their relationship with tumor-associated macrophages. Cerebrospinal fluid of GBM patients was classified into two major clusters. sCD163 concentration correlated with the amount of CD163-positive tumor-associated macrophages infiltrating into the tumor, and sTNF-R1, sTNF-R2, TNFSF13, TNSFSF13B, sIL-6Ra, Pentraxin, and MMP-2 had a strong positive correlation, however,IL-35, IL-32, IL-34, IFN-b, IL-22 had a strong negative correlation. In addition, patients with low IFN-b, IL-2, IL-22 IL-34, IL-35 had a significantly worse prognosis.
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