| Project/Area Number |
21K15577
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 50020:Tumor diagnostics and therapeutics-related
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| Research Institution | Kawasaki Institute of Industrial Promotion Innovation Center of NanoMedicine (2023)
Tokyo University of Science (2021-2022) |
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Principal Investigator |
DOAN THI KIM DUNG 公益財団法人川崎市産業振興財団(ナノ医療イノベーションセンター), ナノ医療イノベーションセンター, 研究員 (70838870)
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Project Status |
Completed (Fiscal Year 2023)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2023: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2022: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2021: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | NIR / MRI / Herceptin / IR-1061 / HER2 / Gd-DOTA / OTN-NIR / multimodal imaging / breast cancer / herceptin / Her 2 / Breast cancer / Bioimaging / Imaging probe |
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| Outline of Research at the Start |
This project develops a bimodal OTN-NIR and MR imaging probe for targeting breast cancer. MRI can navigate and localize cancer tumors in the body. OTN-NIR can provide volumetric images of tumors with high sensitivity and resolution. This probe is promising for using in surgical aid imaging.
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| Outline of Final Research Achievements |
The research succeeded to develop bimodal imaging probe from organic compounds. The nanostructure design of polymer micelles based on PLGA-b-PEG introduced with an OTN-NIR fluorescent dye and Gd-DOTA as a bimodal, OTN-NIR fluorescence, and MRI imaging probe with ca. 20 nm size. It demonstrated well bright OTN-NIR fluorescence and MRI contrast enhancement to depict the blood circulation and to observe the organs in live mice. The probe exhibited absorption and emission in
OTN-NIR and T1 contrast enhancement effect in MRI. The imaging results revealed that the Gd-DOTA introduction ratio and locations are important to control the biological response of the probe without losing the imaging contrasts.
The Herceptin antibody was also conjugated on the surface of the imaging probe and showed the potential to selectively target HER2 breast cancer cells.
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| Academic Significance and Societal Importance of the Research Achievements |
The development of a bi-modal NIR/MRI probe for imaging breast cancer enhances diagnostic precision, enables early-accurate tumor detection, and reduces the need for invasive procedures.
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