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Elucidation of the molecular pathogenesis of lymphoma with a focus on PVT1 RNA and its application to novel targeted therapy

Research Project

Project/Area Number 21K15579
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 50020:Tumor diagnostics and therapeutics-related
Research InstitutionAichi Medical University

Principal Investigator

Mizuno Shohei  愛知医科大学, 医学部, 准教授 (70556638)

Project Period (FY) 2021-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2023: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2022: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2021: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsびまん性大細胞性B細胞リンパ腫 / PVT1 / long non-coding遺伝子 / 8q24 / 環状RNA / long non-coding RNA / リンパ腫 / びまん性大細胞型B細胞リンパ腫
Outline of Research at the Start

ゲノム異常に伴う遺伝子発現過剰は、リンパ腫の発症や進展に直接的に関与する。近年、染色体8q24領域において、MYC近傍に座位するPVT1が新たながん遺伝子として着目されている。PVT1は、環状RNAを形成し、固形がんの薬剤感受性に関与する。研究代表者は、PVT1過剰発現を示したB細胞リンパ腫の細胞株を樹立し、PVT1がビンクリスチン耐性に関与することを見出した。そこで、PVT1がリンパ腫の病態に関わり、薬剤耐性や予後に関連することを解明する。本研究により、PVT1高発現を認めるB細胞リンパ腫の新たな分子病態の解明と、PVT1を標的とした新しい治療の開発が期待できる。

Outline of Final Research Achievements

To elucidate the role of PVT1 in lymphoma pathogenesis and its relevance to drug resistance and prognosis, we conducted this study. We observed a trend toward increased expression of PVT1 and cyclic PVT1 in a group of EZH2-positive diffuse large B-cell lymphoma (DLBCL) cells. Furthermore, by knocking down MYC, PVT1 and cyclic PVT1 in DLBCL cell lines, we are invesitigating that MYC and cyclic PVT1 contribute to increased cell proliferation and decreased sensitivity to each drug in R-CHOP therapy.

Academic Significance and Societal Importance of the Research Achievements

リンパ腫の中で、びまん性大細胞性B細胞リンパ腫(DLBCL)が30%以上と最も多くを占める。DLBCL 患者の10%程度が初回治療抵抗性となり、さらに25%程度が再発するとされている。さらに、再発、治療抵抗性DLBCLの予後は、生存期間中央値 6.3 ヶ月、2 年生存率20%と極めて不良である。本研究結果はPVT1が一部のDLBCLの難治性や薬剤耐性に影響することを解明する一助になりうるものと考えられる。今後はDLBCLの難治性や薬剤耐性の問題を克服するため、PVT1と治療についてさらなる研究が必要である。

Report

(4 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • Research Products

    (39 results)

All 2024 2023 2022 2021

All Journal Article (25 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 22 results,  Open Access: 6 results) Presentation (14 results) (of which Int'l Joint Research: 6 results)

  • [Journal Article] Allogeneic hematopoietic cell transplantation for acute myeloid leukemia with <i>BCR::ABL1</i> fusion2024

    • Author(s)
      Mizuno Shohei、Takami Akiyoshi、Kawamura Koji、Harada Kaito、Masayoshi Masuko、Yano Shingo、Ito Ayumu、Ozawa Yukiyasu、Ouchi Fumihiko、Ashida Takashi、Nawa Yuichiro、Ichinohe Tatsuo、Fukuda Takahiro、Atsuta Yoshiko、Yanada Masamitsu
    • Journal Title

      eJHaem

      Volume: 5 Issue: 2 Pages: 369-378

    • DOI

      10.1002/jha2.877

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic factors in haploidentical transplantation with post-transplant cyclophosphamide for acute myeloid leukemia2024

    • Author(s)
      Shibata Sho、Arai Yasuyuki、Kondo Tadakazu、Mizuno Shohei、Yamasaki Satoshi、Akasaka Takashi、Doki Noriko、Ota Shuichi、Maruyama Yumiko、Matsuoka Ken-ichi、Nagafuji Koji、Eto Tetsuya、Tanaka Takashi、Ohigashi Hiroyuki、Nakamae Hirohisa、Onizuka Makoto、Fukuda Takahiro、Atsuta Yoshiko、Yanada Masamitsu
    • Journal Title

      Cytotherapy

      Volume: N.A Issue: 6 Pages: 592-598

    • DOI

      10.1016/j.jcyt.2024.02.010

    • Related Report
      2023 Annual Research Report
  • [Journal Article] ARK5 enhances cell survival associated with mitochondrial morphological dynamics from fusion to fission in human multiple myeloma cells.2024

    • Author(s)
      Karnan S, Hanamura I, Ota A, Vu LQ, Uchino K, Horio T, Murakami S, Mizuno S, Rahman ML, Wahiduzzaman M, Hasan MN, Biswas M, Hyodo T, Ito H, Suzuki A, Konishi H, Tsuzuki S, Hosokawa Y, Takami A.
    • Journal Title

      Cell Death Discov.

      Volume: 10(1):56. Issue: 1 Pages: 56-56

    • DOI

      10.1038/s41420-024-01814-w

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Comparison of Allogeneic Transplant Outcomes Between Matched Sibling Donors and Alternative Donors in Patients Over 50 Years of Age with Acute Myeloid Leukemia: 8/8 Allele-Matched Unrelated Donors and Unrelated Cord Blood Provide Better Leukemia-Free Survival Compared with Matched Sibling Donors During Nonremission Status2024

    • Author(s)
      Konuma T, Yamasaki S, Ishiyama K, Mizuno S, Hayashi H, Uchida N, Shimabukuro M, Tanaka M, Kuriyama T, Onizuka M, Ishiwata K, Sawa M, Tanaka T, Ohigashi H, Fujiwara SI, Matsuoka KI, Ota S, Nishida T, Kanda Y, Fukuda T, Atsuta Y, Nakasone H, Yanada M
    • Journal Title

      Transplantation and Cellular Therapy

      Volume: 30 Issue: 2 Pages: 215.e1-215.e18

    • DOI

      10.1016/j.jtct.2023.12.002

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Real-world clinical characteristics of post-essential thrombocythemia and post-polycythemia vera myelofibrosis2023

    • Author(s)
      Shide K, Takenaka K, Kitanaka A, Numata A, Kameda T, Yamauchi T, Inagaki A, Mizuno S, Takami A, Ito S, Hagihara M, Usuki K, Maekawa T, Sunami K, Ueda Y, Tsutsui M, Ando M, Komatsu N, Ozawa K, Kurokawa M, Arai S, Mitani K, Akashi K, Shimoda K
    • Journal Title

      Annals of Hematology

      Volume: 103 Issue: 1 Pages: 97-103

    • DOI

      10.1007/s00277-023-05528-4

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Changing trends in the risk factors for second primary malignancies after autologous stem cell transplantation for multiple myeloma before and after the introduction of proteasome inhibitors and immunomodulatory drugs2023

    • Author(s)
      Takamatsu Hiroyuki、Matsuda Tomohiro、Mizuno Shohei、Takahashi Tsutomu、Fuchida Shin-ichi、Hanamura Ichiro、Kataoka Keisuke、Tsukada Nobuhiro、Matsumoto Morio、Hangaishi Akira、Doki Noriko、Uchida Naoyuki、Sawa Masashi、Maruyama Yumiko、Kurahashi Shingo、Nagafuji Koji、Harazaki Yoriko、et al
    • Journal Title

      Haematologica

      Volume: 108 Issue: 12 Pages: 3399-3408

    • DOI

      10.3324/haematol.2023.283202

    • Related Report
      2023 Annual Research Report
  • [Journal Article] Nationwide prospective survey of secondary myelofibrosis in Japan: superiority of DIPSS-plus to MYSEC-PM as a survival risk model2023

    • Author(s)
      Shide K, Takenaka K, Kitanaka A, Numata A, Kameda T, Yamauchi T, Inagaki A, Mizuno S, Takami A, Ito S, Hagihara M, Usuki K, Maekawa T, Sunami K, Ueda Y, Tsutsui M, Ando M, Komatsu N, Ozawa K, Kurokawa M, Arai S, Mitani K, Akashi K, Shimoda K
    • Journal Title

      Blood Cancer Journal

      Volume: 13 Issue: 1 Pages: 110-110

    • DOI

      10.1038/s41408-023-00869-9

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] External validation and extended application of the transplant conditioning intensity score in acute myeloid leukemia2023

    • Author(s)
      Yanada M, Shimomura Y, Mizuno S, Matsuda K, Kondo T, Doki N, Tanaka M, Fukuda T, Ara T, Uchida N, Onizuka M, Sawa M, Ozawa Y, Hiramoto N, Ota S, Kanda J, Kanda Y, Ichinohe T, Okamoto S, Atsuta Y, Konuma T
    • Journal Title

      Bone Marrow Transplantation

      Volume: 58 Issue: 10 Pages: 1096-1103

    • DOI

      10.1038/s41409-023-02037-w

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adverse impact of delay of platelet recovery after autologous hematopoietic cell transplantation for aggressive non-Hodgkin lymphoma and multiple myeloma2023

    • Author(s)
      Okada Yosuke、Kimura Fumihiko、Kurita Naoki、Takahashi Hiroyuki、Shimazu Yutaka、Mizuno Shohei、Uchida Naoyuki、Kataoka Keisuke、Hiramoto Nobuhiro、Ota Shuichi、Kako Shinichi、Tsukada Nobuhiro、Kanda Yoshinobu、Kurahashi Shingo、Doki Noriko、Nishikawa Akinori、Kim Sung-Won、Hangaishi Akira、et al
    • Journal Title

      Cytotherapy

      Volume: 25 Issue: 11 Pages: 1212-1219

    • DOI

      10.1016/j.jcyt.2023.05.015

    • Related Report
      2023 Annual Research Report
  • [Journal Article] Development of TCR-T cell therapy targeting mismatched HLA-DPB1 for relapsed leukemia after allogeneic transplantation.2023

    • Author(s)
      Barakat C, Inagaki Y, Mizuno S, Nishio N, Katsuyama N, Sato Y, Kobayashi M, Ozeki K, Iida H, Tomita A, Sawa M, Demachi-Okamura A, Takahashi Y, Nishikawa H, Akatsuka Y.
    • Journal Title

      Int J Hematol

      Volume: 118 Issue: 2 Pages: 252-266

    • DOI

      10.1007/s12185-023-03621-y

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Efficacy and safety of allogeneic hematopoietic cell transplantation in acute myeloid leukemia patients aged > 65 years with unfavorable cytogenetics.2023

    • Author(s)
      Yamasaki S, Mizuno S, Iwasaki M, Seo S, Uchida N, Shigesaburo M, Nakano N, Ishiwata K, Uehara Y, Eto T, Takase K, Kawakita T, Tanaka M, Sawa M, Katayama Y, Nawa Y, Makoto O, Ichinohe T, Atsuta Y, Kanda J, Yanada M.
    • Journal Title

      Ann Hematol.

      Volume: 102 Issue: 6 Pages: 1549-1559

    • DOI

      10.1007/s00277-023-05243-0

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autologous hematopoietic cell transplantation for myeloma patients with hepatitis B virus or hepatitis C virus in the era of novel agents2022

    • Author(s)
      Mizuno Shohei、Takami Akiyoshi、Takamatsu Hiroyuki、Hanamura Ichiro、Shimazu Yutaka、Hangaishi Akira、Tsukada Nobuhiro、Kako Shinichi、Kikuchi Taku、Ota Shuichi、Shimizu Hiroaki、Iida Shinsuke、Yoshioka Satoshi、Sawa Masashi、Fukuda Takahiro、Kanda Yoshinobu、Atsuta Yoshiko、Kawamura Koji
    • Journal Title

      Bone Marrow Transplantation

      Volume: 1 Issue: 5 Pages: 1-10

    • DOI

      10.1038/s41409-022-01640-7

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Successful preventive treatment with cyclosporine in a patient with relapsed/refractory immune-mediated thrombotic thrombocytopenic purpura: a case report and review of the literature2022

    • Author(s)
      Uchino Kaori、Sakai Kazuya、Shinohara Saki、Matsuhisa Akifumi、Iida Yusuke、Nakano Yuta、Matsumura Saori、Kanasugi Jo、Takasugi Soichi、Nakamura Ayano、Horio Tomohiro、Murakami Satsuki、Mizuno Shohei、Yamamoto Hidesuke、Hanamura Ichiro、Matsumoto Masanori、Takami Akiyoshi
    • Journal Title

      International Journal of Hematology

      Volume: 1 Issue: 2 Pages: 1-10

    • DOI

      10.1007/s12185-022-03319-7

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Efficacy of a 365?nm Ultraviolet A1 light Emitting Diode (UVA1‐LED) in <i>in?vitro</i> Extracorporeal Photopheresis2022

    • Author(s)
      Maeda Akira、Yamamoto Riho、Mizuno Shohei、Miki Shigeichiro、Sakamoto Yasuhiro、Kogata Shuhei、Toyama Chiyoshi、Sato Kazuki、Okamatsu Chizu、Ando Takanori、Iida Minako、Watsuji Toru、Sato Toshinobu、Miyagawa Shuji、Okuyama Hiroomi、Takami Akiyoshi、Kodera Yoshitaka
    • Journal Title

      Photochemistry and Photobiology

      Volume: 1 Issue: 5 Pages: 1-10

    • DOI

      10.1111/php.13613

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Donor lymphocyte infusion after haploidentical hematopoietic stem cell transplantation for acute myeloid leukemia2022

    • Author(s)
      Harada Kaito、Mizuno Shohei、Yano Shingo、Takami Akiyoshi、Ishii Hiroto、Ikegame Kazuhiro、Najima Yuho、Kako Shinichi、Ashida Takashi、Shiratori Souichi、Ota Shuichi、Onizuka Makoto、Fukushima Kentaro、Fukuda Takahiro、Ichinohe Tatsuo、Atsuta Yoshiko、Yanada Masamitsu
    • Journal Title

      Annals of Hematology

      Volume: 101 Issue: 3 Pages: 643-653

    • DOI

      10.1007/s00277-021-04731-5

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comparing cord blood transplantation and matched related donor transplantation in non-remission acute myeloid leukemia2022

    • Author(s)
      Shimomura Y, Takahashi S., et al.
    • Journal Title

      Leukemia

      Volume: 36 Issue: 4 Pages: 1132-1138

    • DOI

      10.1038/s41375-021-01474-0

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Improved survival of multiple myeloma patients treated with autologous transplantation in the modern era of new medicine2021

    • Author(s)
      Shimazu Yutaka、Mizuno Shohei、Fuchida Shin‐ichi、Suzuki Kazuhito、Tsukada Nobuhiro、Hanagaishi Akira、Itagaki Mitsuhiro、Kataoka Keisuke、Kako Shinichi、Sakaida Emiko、Yoshioka Satoshi、Iida Shinsuke、Doki Noriko、Oyake Tatsuo、Ichinohe Tatsuo、Kanda Yoshinobu、Astuta Yoshiko、Takamatsu Hiroyuki
    • Journal Title

      Cancer Science

      Volume: 112 Issue: 12 Pages: 5034-5045

    • DOI

      10.1111/cas.15163

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Syngeneic hematopoietic stem cell transplantation for acute myeloid leukemia: a propensity score-matched analysis2021

    • Author(s)
      Kurosawa Shuhei、Mizuno Shohei、Arai Yasuyuki、Masuko Masayoshi、Kanda Junya、Kohno Kentaro、Onai Daishi、Fukuda Takahiro、Ozawa Yukiyasu、Katayama Yuta、Tanaka Masatsugu、Ikegame Kazuhiro、Uchida Naoyuki、Eto Tetsuya、Ota Shuichi、Tanaka Junji、Ichinohe Tatsuo、Atsuta Yoshiko、Yanada Masamitsu
    • Journal Title

      Blood Cancer Journal

      Volume: 11 Issue: 9

    • DOI

      10.1038/s41408-021-00553-w

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The differential effect of disease status at allogeneic hematopoietic cell transplantation on outcomes in acute myeloid and lymphoblastic leukemia2021

    • Author(s)
      Yanada M, Konuma T, Yamasaki S, Mizuno S, Hirabayashi S, Nishiwaki S, Uchida N, Doki N, Tanaka M, Ozawa Y, Sawa M, Eto T, Kawakita T, Ota S, Fukuda T, Onizuka M, Kimura T, Atsuta Y, Kako S, Yano S
    • Journal Title

      Ann Hematol

      Volume: 100 Issue: 12 Pages: 3017-3027

    • DOI

      10.1007/s00277-021-04661-2

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Difference in outcomes following allogeneic hematopoietic cell transplantation for patients with acute myeloid leukemia and myelodysplastic syndromes2021

    • Author(s)
      Yanada Masamitsu、Mizuno Shohei、Yamasaki Satoshi、Harada Kaito、Konuma Takaaki、Tamaki Hiroya、Shingai Naoki、Uchida Naoyuki、Ozawa Yukiyasu、Tanaka Masatsugu、Onizuka Makoto、Sawa Masashi、Nakamae Hirohisa、Shiratori Souichi、Matsuoka Ken-ichi、Eto Tetsuya、Kawakita Toshiro、Maruyama Yumiko、et al
    • Journal Title

      Leukemia &amp; Lymphoma

      Volume: 62 Issue: 14 Pages: 3411-3419

    • DOI

      10.1080/10428194.2021.1961242

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comparison of fludarabine, a myeloablative dose of busulfan, and melphalan vs conventional myeloablative conditioning regimen in patients with relapse and refractory acute myeloid leukemia in non-remission status2021

    • Author(s)
      Shimomura Yoshimitsu、Hara Masahiko、Hirabayashi Shigeki、Kondo Tadakazu、Mizuno Shohei、Uchida Naoyuki、Mukae Junichi、Kawakita Toshiro、Fukuda Takahiro、Kanda Yoshinobu、Ota Shuichi、Ozawa Yukiyasu、Eto Tetsuya、Maruyama Yumiko、Tanaka Masatsugu、et al
    • Journal Title

      Bone Marrow Transplantation

      Volume: 56 Issue: 9 Pages: 2302-2304

    • DOI

      10.1038/s41409-021-01380-0

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Single Cord Blood Transplantation Versus Unmanipulated Haploidentical Transplantation for Adults with Acute Myeloid Leukemia in Complete Remission.2021

    • Author(s)
      Konuma T, Kanda J, Yamasaki S, Harada K, Shimomura Y, Terakura S, Mizuno S, Uchida N, Tanaka M, Doki N, Ozawa Y, Nakamae H, Sawa M, Matsuoka KI, Morishige S, Maruyama Y, Ikegame K, Kimura T, Kanda Y, Ichinohe T, Atsuta Y, Yanada M.
    • Journal Title

      Transplant Cell Ther.

      Volume: 27(4) Issue: 4 Pages: 334.e1-334.e11

    • DOI

      10.1016/j.jtct.2021.01.023

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Allogeneic Hematopoietic Cell Transplantation for Adolescent and Young Adult Patients with Acute Myeloid Leukemia2021

    • Author(s)
      Mizuno Shohei、Takami Akiyoshi、Kawamura Koji、Arai Yasuyuki、Kondo Tadakazu、Kawata Takahito、Uchida Naoyuki、Marumo Atsushi、Fukuda Takahiro、Tanaka Masatsugu、Ozawa Yukiyasu、Yoshida Shuro、Ota Shuichi、Takada Satoru、Sawa Masashi、Onizuka Makoto、Kanda Yoshinobu、Ichinohe Tatsuo、Atsuta Yoshiko、Yanada Masamitsu
    • Journal Title

      Transplantation and Cellular Therapy

      Volume: 27 Issue: 4 Pages: 314.e1-314.e10

    • DOI

      10.1016/j.jtct.2020.12.013

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Donor UNC-93 Homolog B1 genetic polymorphism predicts survival outcomes after unrelated bone marrow transplantation.2021

    • Author(s)
      Uchino K, Vu Quang L, Mizuno S, Horio T, Yamamoto H, Hanamura I, Kodera Y, Luis Espinoza J, Onizuka M, Kashiwase K, Morishima Y, Fukuda T, Doki N, Miyamura K, Mori T, Morishita E, Nakao S, Takami A
    • Journal Title

      Genes and Immunity

      Volume: 24 Issue: 1 Pages: 1-9

    • DOI

      10.1038/s41435-021-00122-y

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Outcome of allogeneic hematopoietic stem cell transplantation for follicular lymphoma relapsing after autologous transplantation: analysis of the Japan Society for Hematopoietic Cell Transplantation2021

    • Author(s)
      Sakurai Masatoshi、Mori Takehiko、Kato Koji、Kanaya Minoru、Mizuno Shohei、Shiratori Souichi、Wakayama Toshio、Uchida Naoyuki、Kobayashi Hikaru、Kubo Kohmei、Amano Itsuto、Ohta Takanori、Miyazaki Yasuhiko、Kanda Junya、Fukuda Takahiro、Atsuta Yoshiko、Kondo Eisei、et al
    • Journal Title

      Bone Marrow Transplantation

      Volume: 56 Issue: 6 Pages: 1462-1466

    • DOI

      10.1038/s41409-020-01192-8

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Presentation] Identifying the Optimal Conditioning Intensity of Hematopoietic Stem Cell Transplantation in Patients with Acute Myeloid Leukemia in Complete Remission2023

    • Author(s)
      Yoshimitsu Shimomura, Sho Komukai, Tetsuhisa Kitamura, Tomotaka Sobue, Satoshi Yamasaki, Tadakazu Kondo, Shohei Mizuno, et al
    • Organizer
      ASH 2023 第65回米国血液学会
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Impact of Age on Outcome in Newly Diagnosed Multiple Myeloma Patients Undergoing Upfront Autologous Hematopoietic Cell Transplantation from the Worldwide Network for Blood and Marrow Transplantation Global Study2023

    • Author(s)
      Shohei Mizuno, MD, PhD1*, Luuk Gras Sr, et al.
    • Organizer
      ASH 2023 第65回米国血液学会
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] No evidence for improved overall survival or progression-free survival in multiple myeloma patients aged 70-75 undergoing frontline autologous stem cell transplantation compared to a non-transplant strategy2023

    • Author(s)
      Riva E, Kastritis E, Gras L, Koster L, Caillot D, Tucci A, Lanza F, Musso M, Sirvent A, Illes A, Ram R, Bonifazi F, Bourhis JH, Zuckerman T, Mizuno S, et al
    • Organizer
      49th annual meeting of the EBMT
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] International Differences in Baseline Characteristics and Practice Patterns in Patients with Newly Diagnosed Multiple Myeloma Undergoing Upfront Autologous Stem Cell Transplantation2023

    • Author(s)
      L. Garderet, L. Gras, L. Koster, A. D’Souza, N. Estrada, H. Parameswaran, W. Saber, A. Cowan, M. Iida, O. Shin, H. Takamatsu, S. Mizuno, et al.
    • Organizer
      49th annual meeting of the EBMT
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] WorldwideNetwork for Blood and MarrowTransplantation (WBMT) Global Studyon Baseline Characteristicsand ClinicalOutcomesin NewlyDiagnosedMultiple MyelomaPatients UndergoingUpfrontAutologousStem CellTransplantation, a StudyOff 61,725 Patients from629 Centers2023

    • Author(s)
      L. Garderet, L. Gras, L. Koster, A. D’Souza, N. Estrada, H. Parameswaran, W. Saber, A. Cowan, M. Iida, O. Shin, H. Takamatsu, S. Mizuno, et al.
    • Organizer
      49th annual meeting of the EBMT
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] BCR::ABL1融合遺伝子を有する急性骨髄性白血病に対する同種造血細胞移植成績2023

    • Author(s)
      水野 昌平, 高見 昭良, 河村 浩二, 原田 介斗, 増子 正義, 矢野 真吾, 伊藤 歩, 小澤 幸康, 大内 史彦, 芦田 隆司, 名和 由一郎, 一戸 辰夫, 福田 隆浩, 熱田 由子, 柳田 正光
    • Organizer
      第85回日本血液学会学術集会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 急性骨髄性白血病における同種移植前処置強度スコアの外部検証2023

    • Author(s)
      柳田 正光, 下村 良充, 水野 昌平, 松田 健佑, 近藤 忠一, 土岐 典子, 田中 正嗣, 福田 隆浩, 荒 隆英, 内田 直之, 鬼塚 真仁, 澤 正史, 小澤 幸泰, 平本 展大, 太田 秀一, 諫田 淳也, 神田 善伸, 一戸 辰夫, 岡本 真一郎, 熱田 由子, 小沼 貴晶
    • Organizer
      第85回日本血液学会学術集会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 急性骨髄性白血病における移植後シクロホスファミドを用いたハプロ移植の予後因子解析2023

    • Author(s)
      柴田 翔, 新井 康之, 近藤 忠一, 山崎 聡, 水野 昌平, 中前 博久, 荒 隆英, 衛藤 徹也, 長藤 宏司, 鬼塚 真仁, 福田 隆浩, 熱田 由子, 柳田 正光
    • Organizer
      第85回日本血液学会学術集会
    • Related Report
      2023 Annual Research Report
  • [Presentation] INTERNATIONAL DIFFERENCES IN BASELINE CHARACTERISTICS AND PRACTICE PATTERNS IN NEWLY DIAGNOSED MULTIPLE MYELOMA(MM) PATIENTS UNDERGOING UPFRONT AUTOLOGOUS STEM CELL TRANSPLANTATION2022

    • Author(s)
      L.Garderet; I.Koster, A.D'Souza, n.Estrada, h.Parameswaran, W.Saber, A.Cowan, m.Iida, O.Shin, h.Takamatsu, s.Mizuno, et al
    • Organizer
      第48回欧州骨髄移植学会議 EBMT 2022 The 48th Annual Meeting
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] ゲノム編集をもちいたFLT3-ITD変異白血病の新規治療標的の探索2021

    • Author(s)
      花村一朗、シバスンダラン・カルナン、太田明伸、高杉壮一、中村文乃、髙橋美裕希、内野かおり、村上五月、水野昌平、鈴木進、上田龍三、高見昭良
    • Organizer
      第4回東海北陸HLA研究会
    • Related Report
      2021 Research-status Report
  • [Presentation] Disease status at allogeneic HCT and post-transplant outcomes: A difference between AML and ALL2021

    • Author(s)
      柳田 正光、小沼 貴晶、山崎 聡、水野 昌平、平林 茂樹、西脇 聡史、内田 直之、土岐 典子、田中 正嗣、小澤 幸泰、澤 正史、衛藤 徹也、河北 敏郎、太田 秀一、福田 隆浩、鬼塚 真仁、木村 貴文、熱田 由子、賀古 真一、矢野 真吾
    • Organizer
      第83回血液学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] Peripheral-blood stem cells versus bone marrow from unrelated donors for adult AML patients2021

    • Author(s)
      城 友泰、新井 康之、近藤 忠一、水野 昌平、平林 茂樹、稲本 賢弘、諫田 淳也、土岐 典子、福田 隆浩、小澤 幸泰、片山 雄太、神田 善伸、鬼塚 真仁、一戸 辰夫、熱田 由子、柳田 正光
    • Organizer
      第83回血液学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] 水野 昌平、高見 昭良、花村 一朗、河村 浩二、島津 裕、半下石 明、塚田 信弘、賀古 真一、菊池 拓、太田 秀一、土岐 典子、飯田 真介、吉岡 聡、澤 正吏、福田 隆浩、神田 善伸、熱田 由子、高松 博幸2021

    • Author(s)
      Autologous hematopoietic cell transplantation in multiple myeloma patients infected with HBV or HCV
    • Organizer
      第83回血液学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] Analysis of FXIII activity in the patients with chronic DIC2021

    • Author(s)
      中山 享之、大坪 弘明、水野 昌平、小川 実加
    • Organizer
      第83回血液学会学術集会
    • Related Report
      2021 Research-status Report

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Published: 2021-04-28   Modified: 2025-01-30  

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