Applications of muon in cancer research
| Project/Area Number |
21K15583
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 50020:Tumor diagnostics and therapeutics-related
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| Research Institution | High Energy Accelerator Research Organization |
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Principal Investigator |
PANT Amba・Datt 大学共同利用機関法人高エネルギー加速器研究機構, 物質構造科学研究所, 研究員 (60760121)
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| Project Period (FY) |
2021-04-01 – 2025-03-31
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| Project Status |
Granted (Fiscal Year 2023)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2023: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2022: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2021: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | Hypoxia / muonium / tumor / cancer / muon and muonium / muon technique |
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| Outline of Research at the Start |
Using quantum beam of muon available in accelerator facilities, detection/behavior of oxygen content in haemoglobin, blood plasma and red blood cell, and in their inhomogeneous systems will be understood. The outcome from this study will help to pave the way for development of noninvasive tool of muon (as a long term goal) to diagnosis the cancer in early stage.
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| Outline of Annual Research Achievements |
As proposed and planned, to achieve long-term goal of detection of the molecular oxygen in biosamples using muon method to apply the muon method in cancer research, the systematic studies were performed in water, buffer and derivatives of hemoglobin using the muon. As a next step, the detection of oxygen in biosamples (hemoglobin, blood plasma under physiological conditions) and inhomogeneous system of hemoglobin and blood plasma will be performed within the extended project period.
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| Current Status of Research Progress |
Current Status of Research Progress
3: Progress in research has been slightly delayed.
Reason
Even though, I proposed to study directly from biosamples (hemoglobin, blood plasma, etc.) but at the starting of this study the temperature dependent
oscillating spectra in water attracted the focus. Now we summarize those data that provides new insight into muon spectroscopy. It makes delay in progress.
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| Strategy for Future Research Activity |
So far, the temperature dependent behavior in water and buffer were understood. For further study these water and buffer data provides background information for study in biomolecules like hemoglobin and real tissues. In the remaining time of the project, detection of oxygen in biosamples under physiological conditions.
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Report
(3 results)
Research Products
(22 results)
