| Project/Area Number |
21K15609
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 51010:Basic brain sciences-related
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| Research Institution | Kyoto University |
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Principal Investigator |
Veale Richard 京都大学, 医学研究科, 助教 (80828880)
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| Project Period (FY) |
2021-04-01 – 2025-03-31
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| Project Status |
Granted (Fiscal Year 2023)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2023: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2022: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2021: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | Saliency map / Neuroprosthesis / Visual attention / Marmoset / Silicon Probe / Spiking simulation / Free Viewing / Superior Colliculus / Blindsight / Gaze Behavior / Saliency / Neural Prosthesis / Visual Attention |
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| Outline of Research at the Start |
I will record brain activity in marmoset monkeys to understand how visual features like color or motion pull visual attention. The goal is to understand how the brain calculates which interesting thing to look at when there are many interesting things visible. This will help us build neural prosthetics that will directly stimulate the brain to repair deficits in attentional behavior caused by brain damage.
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| Outline of Annual Research Achievements |
We have collected data from silicon probe implantations in marmoset viewing free-viewing video, and prepared the complex software necessary for both statistical analysis of the gaze data, as well as estimation of parameters of models for predicting the gaze data given visual input (i.e. saliency maps). The next steps will be active stimulation and multi-probe implantations.
In addition, we have been collecting significant data from human infants and adults to confirm the application of the model beyond marmosets and to better understand the differences between species that may limit adoption of the prosthesis in humans.
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| Current Status of Research Progress |
Current Status of Research Progress
4: Progress in research has been delayed.
Reason
Due to limitations on experiment time, technical difficulties with surgery/implantation, and difficult developing the statistical software, the project is significantly delayed. However, I hope to show significant and interesting results within this final year.
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| Strategy for Future Research Activity |
It is possible that closed-loop stimulation will not be fully achievable by the end of the project. However, full model of marmoset SC and simulated expectation and sham stimulation should be possible in at least one animal. This year we plan to (1) continue free-viewing experiments with silicon probe recording from SC (2) Fit models (spiking network stimulation) and (3) attempt closed-loop stimulation. Additionally, we have prepared an animal for V1 lesion but it is unclear if recovery from the lesion will be ready before the end of this research grant (although we will publish the results aftewards).
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