| Project/Area Number |
21K15680
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 52020:Neurology-related
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2021-04-01 – 2025-03-31
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| Project Status |
Granted (Fiscal Year 2023)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2022: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2021: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | Cognitive neuroscience / Parkinson's disease / rTMS / EEG / Eye tracking / Illusions / Pareidolia / TMS / Psychosis / Neurostimulation |
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| Outline of Research at the Start |
Psychosis in Parkinson's disease adversely impairs patients' quality of life. In this proposal, we target a specific visual symptom of early psychosis called 'pareidolia' and utilize non-invasive brain stimulation in elucidating the role of frontal cortex in modulating symptoms of early psychosis.
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| Outline of Annual Research Achievements |
We have created a database of potential patients for recruitment of patients with Parkinson's disease (PD) without dementia. The jRCT file have been revised considering the start of the new year (2024/4) although the project goals have remained unchanged.
We highlight the safety and efficacy data of cTBS stimulation in PD patients and contemplate its usage in the management of psychosis related symptoms such as hallucinations.
2 internal conference presentations have been done to disseminate information to the neurology residents. Site visit by Korean and international researchers was done in our department (Osaka University, Dept. of Neurology) to showcase our testing methodology. Some preliminary discussions with the Seoul National University Bundang hospital for a research collaboration were done.
A detailed methodological paper on the implementation of cTBS synchronized with Eye-tracking EEG paradigm is currenlty under submission. A case series report is being prepared. Some of the limitations with respect to the recruitment and the challenges invoved in patient testing have been highlighted.
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| Current Status of Research Progress |
Current Status of Research Progress
1: Research has progressed more than it was originally planned.
Reason
Currently, some post hoc analysis and evaluation is being undertaken. Patient recruitment has been improvised and a well defined database is being accessed. Maintenance of the database is also performed. Since the initially planned number of patients was not feasible, a case series with similar level of diagnostic significance is achieved. While the methodology remains complex, a multidisciplinary nature of the project is highlighted in our work.
We recovered from some of the hardware challenges associated with cTBS positioning camera. Future challenges are expected in understanding the need and utilization of rTMS in clinical practice.
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| Strategy for Future Research Activity |
The research will now proceed further in understanding how repeat stimulation of cTBS can achieve long term affects in visuoperceptual behavior. The primary use case for such a regimen is in the management of perceptual hallucinations phenomenon. However, more literature review will also be conducted in understanding the effects of repeated cTBS stimulation, efficacy and safety of such use. Although a single cTBS stim train has some stable after effects in visuoperception, long terms effects are unknown.
On a similar level, pareidolia perception is not restricted to PD alone. Other neurodegerative diseases are predisposed to such visuoperceptual deficits, for example, dementia with lewy body (DLB). PD and DLB share several pathological symptoms making rTMS useful for such patients.
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