transdiagnostic and biological subtyping of developmental disorders

• Project/Area Number: 21K15719
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 52030:Psychiatry-related
• Research Institution: Showa University
• Principal Investigator: 青木 悠太 昭和大学, 大学共同利用機関等の部局等, 兼任講師 (70815810)
• Project Period (FY): 2021-04-01 – 2025-03-31
• Project Status: Granted (Fiscal Year 2023)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2024: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2023: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2022: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2021: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: ASD / ADHD / RDoC / MRI

Outline of Research at the Start

ASDとADHDは、その脳画像所見・症状において診断間重複と診断内の異種性が見られ、従来の臨床診断が生物学的特性を保証するのか疑問視されている。この疑問を解決すべく、本研究では小児期～思春期のASD当事者およびADHD当事者の対象として、脳画像と症状の特徴に基づいてサブタイピングを行う。臨床診断に囚われない所に創造性があり、複数の脳画像を用いて生物学的同質性が高い集団を同定することは独自性も高い。生物学的同質性が高い集団が診断とは異なれば診断基準に対して大きな影響を与えうる。更には、生物学的同質性が高い集団ごとに最適な治療法を開発する第一歩となると期待され、社会への波及効果は大きい。

Outline of Annual Research Achievements

昨年に引き続き、脳画像を用いたASD・ADHD当事者の先行研究の解析については、DTIおよびtask fMRIの両方を実施した。DTI研究は主に英国の研究者と共同研究を行いMolecular Psychiatry誌に掲載された。また、task fMRIについては英国・ドイツ・米国の研究者らと論文化を行いAmerican Journal of Psychiatry誌に掲載された。これらの結果を踏まえて新規性の高い解析をオリジナルデータで行っている段階である。

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

撮像についてはすでに終了しており先行研究を踏まえた新規性が高いオリジナルデータを用いた研究を来年度には発表できる見込みであるため、進行は概ね順調であると考えている。

Strategy for Future Research Activity

オリジナルデータの前処理・解析・論文化を行う。実際の作業に関しては同じ施設に所属する同僚研究者だけではなく、英国・イタリア・ドイツ・米国などこれまでの先行研究の解析において協働した研究者らとも協力して行っていく方針である。

Research Products

• [Int'l Joint Research] ニューヨーク大学/Child Mind Institute/University of California, San Francisco(米国)
• [Int'l Joint Research] Kings College London/Southampton University(英国)
• [Int'l Joint Research] Heinrich Heine University(ドイツ)
• [Int'l Joint Research] University of Cagliari(イタリア)
• [Int'l Joint Research] Korea University(韓国)
• [Int'l Joint Research] ニューヨーク大学/Child Mind Instituite(米国)
• [Int'l Joint Research] Kings College London/Southampton University(英国)
• [Int'l Joint Research] Heinrich Heine University(ドイツ)
• [Journal Article] Shared and Specific Neural Correlates of Attention Deficit Hyperactivity Disorder and Autism Spectrum Disorder: A Meta-Analysis of 243 Task-Based Functional MRI Studies (2024)
  • Author(s): Hiroki Tamon, Junya Fujino, Takashi Itahashi, Lennart Frahm, Valeria Parlatini, Yuta Y. Aoki, Francisco Xavier Castellanos, Simon B. Eickhoff, Samuele Cortese,
  • Journal Title: American Journal of Psychiatry Volume: in press
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] White matter alterations in Attention-Deficit/Hyperactivity Disorder (ADHD): a systematic review of 129 diffusion imaging studies with meta-analysis (2023)
  • Author(s): Parlatini Valeria、Itahashi Takashi、Lee Yeji、Liu Siwei、Nguyen Thuan T.、Aoki Yuta Y.、Forkel Stephanie J.、Catani Marco、Rubia Katya、Zhou Juan H.、Murphy Declan G.、Cortese Samuele
  • Journal Title: Molecular Psychiatry Volume: 28 Issue: 10 Pages: 4098-4123
  • DOI: 10.1038/s41380-023-02173-1
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] CRISIS AFAR: an international collaborative study of the impact of the COVID-19 pandemic on mental health and service access in youth with autism and neurodevelopmental conditions (2023)
  • Author(s): Vibert Bethany、Segura Patricia、Gallagher Louise、Georgiades Stelios、、、、Noda Yoshihiro、、、、Leventhal Bennett、Merikangas Kathleen、Milham Michael P.、Di Martino Adriana
  • Journal Title: Molecular Autism Volume: 14 Issue: 1 Pages: 7-7
  • DOI: 10.1186/s13229-022-00536-z
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Decision flexibilities in autism spectrum disorder: an fMRI study of moral dilemmas (2022)
  • Author(s): Tei Shisei、Tanicha Mizuki、Itahashi Takashi、Aoki Yuta Y、Ohta Haruhisa、Qian Chenyu、Hashimoto Ryu-ichiro、Nakamura Motoaki、Takahashi Hidehiko、Kato Nobumasa、Fujino Junya
  • Journal Title: Social Cognitive and Affective Neuroscience Volume: - Issue: 10 Pages: 1-8
  • DOI: 10.1093/scan/nsac023
  • Peer Reviewed / Open Access
• [Journal Article] Autistic children and adolescents with frequent restricted interest and repetitive behavior showed more difficulty in social cognition during mask-wearing during the COVID-19 pandemic: a multisite survey (2022)
  • Author(s): Tamon Hiroki、Itahashi Takashi、Yamaguchi Sosei、Tachibana Yoshiyuki、Fujino Junya、Igarashi Miki、Kawashima Makiko、Takahashi Riina、Shinohara Nozomi A.、Noda Yoshihiro、Nakajima Shinichiro、Hirota Tomoya、Aoki Yuta Y.
  • Journal Title: BMC Psychiatry Volume: 22 Issue: 1 Pages: 608-608
  • DOI: 10.1186/s12888-022-04249-8
  • Peer Reviewed / Open Access
• [Journal Article] Intergroup bias in punishing behaviors of adults with autism spectrum disorder (2022)
  • Author(s): Qian Chenyu、Tei Shisei、Itahashi Takashi、Aoki Yuta Y.、Ohta Haruhisa、Hashimoto Ryu-ichiro、Nakamura Motoaki、Takahashi Hidehiko、Kato Nobumasa、Fujino Junya
  • Journal Title: Frontiers in Psychiatry Volume: 13 Pages: 0-0
  • DOI: 10.3389/fpsyt.2022.884529
  • Peer Reviewed / Open Access
• [Journal Article] Prediction of life satisfaction from resting‐state functional connectome (2021)
  • Author(s): Itahashi Takashi、Kosibaty Neda、Hashimoto Ryu‐Ichiro、Aoki Yuta Y.
  • Journal Title: Brain and Behavior Volume: 11 Issue: 9
  • DOI: 10.1002/brb3.2331
  • Peer Reviewed / Open Access
• [Journal Article] Dimensional distribution of cortical abnormality across antipsychotics treatment-resistant and responsive schizophrenia (2021)
  • Author(s): Itahashi Takashi、Noda Yoshihiro、Iwata Yusuke、Tarumi Ryosuke、Tsugawa Sakiko、Plitman Eric、Honda Shiori、Caravaggio Fernando、Kim Julia、Matsushita Karin、Gerretsen Philip、Uchida Hiroyuki、Remington Gary、Mimura Masaru、Aoki Yuta Y.、Graff-Guerrero Ariel、Nakajima Shinichiro
  • Journal Title: NeuroImage: Clinical Volume: 32 Pages: 102852-102852
  • DOI: 10.1016/j.nicl.2021.102852
  • Peer Reviewed / Open Access / Int'l Joint Research