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Investigation of a method for predicting the molecular biological profile of glioma using PET and MRI.

Research Project

Project/Area Number 21K15826
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 52040:Radiological sciences-related
Research InstitutionKyoto University

Principal Investigator

Sakata Akihiko  京都大学, 医学研究科, 助教 (10838981)

Project Period (FY) 2021-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2023: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2022: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2021: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords神経膠腫 / 低酸素 / 糖代謝 / IDH / TERT / 脳腫瘍 / PET / MRI
Outline of Research at the Start

核医学検査は、脳腫瘍内の糖やアミノ酸などの代謝、低酸素領域やホルモンレセプターの発現といった生物学的な特性を観察するために用いられてきた。しかし、こうした生体内の代謝・微小環境の情報と神経膠腫の遺伝子変異を含めた悪性度との関連性は十分に検討されていない。本研究では、MRI、糖代謝を反映する18F-fluorodeoxyglucose (FDG)-PET、低酸素領域に集積する18F-fluoromisonidazole (FMISO)-PETから得られる様々なイメージング・バイオマーカーを組み合わせ、神経膠腫の分子生物学的悪性度の診断や予後予測モデルの作成を目指す。

Outline of Final Research Achievements

The purpose of this study is to investigate a noninvasive method to predict molecular biological information such as IDH and TERTp mutations in gliomas using morphology, cell density, and blood flow information from MRI and metabolic information such as glucose metabolism and hypoxia from PET. We have shown that hypoxic regions obtained from FMISO-PET are useful for predicting IDH mutations in gliomas. Furthermore, we analyzed the IDH wild type using semi-quantitative indices obtained from PET and MRI in addition to morphological information. Although the biomarkers obtained from this method were useful in determining histological malignancy, we found no significant difference between TERTp mutant and wild-type gliomas, suggesting that their prediction is difficult.

Academic Significance and Societal Importance of the Research Achievements

本研究開始時FMISO-PETを用いた腫瘍の分子生物学的特徴の検討は行われておらず、腫瘍の低酸素領域がIDH野生型の予測に有用であることを明らかにすることができた。さらに、IDH野生型神経膠腫のみを対象としたTERTp変異と画像の関連を評価した研究はごく限られている。本検討ではTERTp変異の有無によって、画像から得られたバイオマーカーには有意差を認めなかったが、神経膠腫の組織学的な悪性度とは有意な相関が見られた。見方を変えれば、画像診断技術を用い神経膠腫の分子生物学的プロファイルを評価・予測する際に、組織学的悪性度が交絡因子となり得ることを示したとも言える結果であった。

Report

(3 results)
  • 2023 Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • Research Products

    (19 results)

All 2023 2022 2021

All Journal Article (16 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 16 results,  Open Access: 7 results) Presentation (3 results)

  • [Journal Article] High intratumoral susceptibility signal grade on susceptibility-weighted imaging: a risk factor for hemorrhage after stereotactic biopsy2023

    • Author(s)
      Tanji Masahiro、Mineharu Yohei、Sakata Akihiko、Okuchi Sachi、Fushimi Yasutaka、Oishi Masahiro、Terada Yukinori、Sano Noritaka、Yamao Yukihiro、Arakawa Yoshiki、Yoshida Kazumichi、Miyamoto Susumu
    • Journal Title

      Journal of Neurosurgery

      Volume: 138 Issue: 1 Pages: 120-127

    • DOI

      10.3171/2022.4.jns212505

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Telomerase reverse transcriptase promoter mutation and histologic grade in IDH wild-type histological lower-grade gliomas: The value of perfusion-weighted image, diffusion-weighted image, and 18F-FDG-PET2023

    • Author(s)
      Ikeda Satoshi、Sakata Akihiko、Fushimi Yasutaka、Okuchi Sachi、Arakawa Yoshiki、Makino Yasuhide、Mineharu Yohei、Nakajima Satoshi、Hinoda Takuya、Yoshida Kazumichi、Miyamoto Susumu、Nakamoto Yuji
    • Journal Title

      European Journal of Radiology

      Volume: 159 Pages: 110658-110658

    • DOI

      10.1016/j.ejrad.2022.110658

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Evaluation of moyamoya disease in CT angiography using ultra-high-resolution computed tomography: Application of deep learning reconstruction2022

    • Author(s)
      Fukushima Yasuhiro、Fushimi Yasutaka、Funaki Takeshi、Sakata Akihiko、Hinoda Takuya、Nakajima Satoshi、Sakamoto Ryo、Yoshida Kazumichi、Miyamoto Susumu、Nakamoto Yuji
    • Journal Title

      European Journal of Radiology

      Volume: 151 Pages: 110294-110294

    • DOI

      10.1016/j.ejrad.2022.110294

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Review and consensus recommendations on clinical <scp>APT</scp> ‐weighted imaging approaches at <scp>3T</scp> : Application to brain tumors2022

    • Author(s)
      Zhou Jinyuan、Zaiss Moritz、Knutsson Linda、Sun Phillip Zhe、Sakata Akihik、Togao Osamu、van Zijl Peter C M et al.
    • Journal Title

      Magnetic Resonance in Medicine

      Volume: 88 Issue: 2 Pages: 546-574

    • DOI

      10.1002/mrm.29241

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Vessel wall MR imaging in neuroradiology2022

    • Author(s)
      Fushimi Yasutaka、Yoshida Kazumichi、Okawa Masakazu、Maki Takakuni、Nakajima Satoshi、Sakata Akihiko、Okuchi Sachi、Hinoda Takuya、Kanagaki Mitsunori、Nakamoto Yuji
    • Journal Title

      La radiologia medica

      Volume: 127 Issue: 9 Pages: 1032-1045

    • DOI

      10.1007/s11547-022-01528-y

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Super-resolution application of generative adversarial network on brain time-of-flight MR angiography: image quality and diagnostic utility evaluation2022

    • Author(s)
      Wicaksono Krishna Pandu、Fujimoto Koji、Fushimi Yasutaka、Sakata Akihiko、Okuchi Sachi、Hinoda Takuya、Nakajima Satoshi、Yamao Yukihiro、Yoshida Kazumichi、Miyake Kanae Kawai、Numamoto Hitomi、Saga Tsuneo、Nakamoto Yuji
    • Journal Title

      European Radiology

      Volume: 33 Issue: 2 Pages: 936-946

    • DOI

      10.1007/s00330-022-09103-9

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comparison of TGSE-BLADE DWI, RESOLVE DWI, and SS-EPI DWI in healthy volunteers and patients after cerebral aneurysm clipping2022

    • Author(s)
      Okuchi Sachi、Fushimi Yasutaka、Yoshida Kazumichi、Nakajima Satoshi、Sakata Akihiko、Hinoda Takuya、Otani Sayo、Sagawa Hajime、Zhou Kun、Yamao Yukihiro、Okawa Masakazu、Nakamoto Yuji
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 17689-17689

    • DOI

      10.1038/s41598-022-22760-6

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Accuracy, repeatability, and reproducibility of T1 and T2 relaxation times measurement by 3D magnetic resonance fingerprinting with different dictionary resolutions2022

    • Author(s)
      Wicaksono Krishna Pandu、Fushimi Yasutaka、Nakajima Satoshi、Sakata Akihiko、Okuchi Sachi、Hinoda Takuya、Oshima Sonoko、Otani Sayo、Tagawa Hiroshi、Urushibata Yuta、Nakamoto Yuji
    • Journal Title

      European Radiology

      Volume: 33 Issue: 4 Pages: 2895-2904

    • DOI

      10.1007/s00330-022-09244-x

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Brain imaging of sequential acquisition using a flexible PET scanner and 3-T MRI: quantitative and qualitative assessment2022

    • Author(s)
      Nakajima Satoshi、Fushimi Yasutaka、Hinoda Takuya、Sakata Akihiko、Okuchi Sachi、Arakawa Yoshiki、Ishimori Takayoshi、Nakamoto Yuji
    • Journal Title

      Annals of Nuclear Medicine

      Volume: 37 Issue: 4 Pages: 209-218

    • DOI

      10.1007/s12149-022-01817-6

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] 18F-FMISO PET of an Intracranial Tuberculoma2022

    • Author(s)
      Sakata Akihiko、Fushimi Yasutaka、Arakawa Yoshiki、Shimizu Yoichi、Nakamoto Yuji
    • Journal Title

      Clinical Nuclear Medicine

      Volume: 48 Issue: 4 Pages: e212-e213

    • DOI

      10.1097/rlu.0000000000004471

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Low-dose contrast-enhanced time-resolved angiography with stochastic trajectories with iterative reconstruction (IT-TWIST-MRA) in brain arteriovenous shunt2022

    • Author(s)
      Sakata Akihiko、Sakamoto Ryo、Fushimi Yasutaka、Nakajima Satoshi、Hinoda Takuya、Oshima Sonoko、Wetzl Jens、Schmidt Michaela、Okawa Masakazu、Yoshida Kazumichi、Miyamoto Susumu、Nakamoto Yuji
    • Journal Title

      European Radiology

      Volume: - Issue: 8 Pages: 5392-5401

    • DOI

      10.1007/s00330-022-08678-7

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Quiet Diffusion-weighted MR Imaging of the Brain for Pediatric Patients with Moyamoya Disease2022

    • Author(s)
      Nakajima Satoshi、Fushimi Yasutaka、Funaki Takeshi、Okubo Gosuke、Sakata Akihiko、Hinoda Takuya、Yokota Yusuke、Oshima Sonoko、Otani Sayo、Kikuchi Takayuki、Okada Tomohisa、Yoshida Kazumichi、Miyamoto Susumu、Nakamoto Yuji
    • Journal Title

      Magnetic Resonance in Medical Sciences

      Volume: 21 Issue: 4 Pages: 583-591

    • DOI

      10.2463/mrms.mp.2020-0174

    • NAID

      130008069290

    • ISSN
      1347-3182, 1880-2206
    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical Application of MPRAGE Wave Controlled Aliasing in Parallel Imaging (Wave-CAIPI): A Comparative Study with MPRAGE GRAPPA2022

    • Author(s)
      Sakurama Azusa、Fushimi Yasutaka、Nakajima Satoshi、Sakata Akihiko、Hinoda Takuya、Oshima Sonoko、Otani Sayo、Wicaksono Krishna Pandu、Liu Wei、Maki Takakuni、Okada Tomohisa、Takahashi Ryosuke、Nakamoto Yuji
    • Journal Title

      Magnetic Resonance in Medical Sciences

      Volume: 21 Issue: 4 Pages: 633-647

    • DOI

      10.2463/mrms.mp.2021-0065

    • NAID

      130008097782

    • ISSN
      1347-3182, 1880-2206
    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Diagnostic Value of DCE-MRI for Differentiating Malignant Adnexal Masses Compared with Contrast-enhanced-T1WI2022

    • Author(s)
      Otani Satoshi、Kido Aki、Himoto Yuki、Sakata Akihiko、Otani Tomoaki、Kuwahara Ryo、Moribata Yusaku、Nishio Naoko、Yajima Ryo、Nakao Kyoko、Kurata Yasuhisa、Minamiguchi Sachiko、Mandai Masaki、Nakamoto Yuji
    • Journal Title

      Magnetic Resonance in Medical Sciences

      Volume: 21 Issue: 4 Pages: 599-607

    • DOI

      10.2463/mrms.mp.2021-0003

    • NAID

      130008083833

    • ISSN
      1347-3182, 1880-2206
    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Differentiation of uterine low-grade endometrial stromal sarcoma from rare leiomyoma variants by magnetic resonance imaging2021

    • Author(s)
      Himoto Yuki、Kido Aki、Sakata Akihiko、Moribata Yusaku、Kurata Yasuhisa、Suzuki Ayako、Matsumura Noriomi、Shitano Fuki、Kawahara Seiya、Kubo Shigeto、Umeoka Shigeaki、Minamiguchi Sachiko、Mandai Masaki
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 19124-19124

    • DOI

      10.1038/s41598-021-98473-z

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Vessel Wall Enhancement on Black-Blood MRI Predicts Acute and Future Stroke in Cerebral Amyloid Angiopathy2021

    • Author(s)
      McNally J.S.、Sakata A.、Alexander M.D.、Dewitt L.D.、Sonnen J.A.、Menacho S.T.、Stoddard G.J.、Kim S.-E.、de Havenon A.H.
    • Journal Title

      American Journal of Neuroradiology

      Volume: 42 Issue: 6 Pages: 1038-1045

    • DOI

      10.3174/ajnr.a7047

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] 18F-FMISO-PETで高集積を呈し、悪性神経膠腫との鑑別に苦慮した結核腫の1例2022

    • Author(s)
      坂田昭彦
    • Organizer
      第62回 日本核医学会学術総会
    • Related Report
      2022 Research-status Report
  • [Presentation] 低用量造影剤を用いた頭頚部IT-TWIST-MRAの初期経験2021

    • Author(s)
      坂田昭彦
    • Organizer
      第49回日本磁気共鳴医学会大会
    • Related Report
      2021 Research-status Report
  • [Presentation] 低用量造影剤を用いた頭頚部IT-TWIST-MRAによるAV shunt描出能の検討2021

    • Author(s)
      坂田昭彦
    • Organizer
      第49回断層映像研究会
    • Related Report
      2021 Research-status Report

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Published: 2021-04-28   Modified: 2025-01-30  

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