| Project/Area Number |
21K16168
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 53040:Nephrology-related
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| Research Institution | Nara Medical University |
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Principal Investigator |
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Project Status |
Completed (Fiscal Year 2023)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2023: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2022: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2021: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ネプリライシン / レニン・アンジオテンシン系 / 食塩感受性高血圧 / アンジオテンシン変換酵素 / 腎臓内アンジオテンシンII濃度 / 食塩感受性 |
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| Outline of Research at the Start |
本研究は、Neprilysin（NEP）およびangiotensin converting enzyme（ACE）の局在性および代謝する基質の類似性に着目して、様々な高血圧モデルにおいて、この2つの酵素がどのように腎内Renin-angiotensin系を介した腎臓でのNaハンドリングおよび血圧調節へ影響を与えているかを検討する。
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| Outline of Final Research Achievements |
Neprilysin (NEP) is a Zn-metalloprotease whose substrate is brain natriuretic peptide (BNP), but also angiotensin II (Ang II). Interestingly, angiotensin converting enzyme (ACE) is also a Zn-metalloprotease, and both are strongly expressed in the brush border of the proximal tubule. These two proteases are thought to be involved in the regulation of sodium balance by regulating the Intrarenal Ang II by the degradation (NEP) and production (ACE) of Ang II.
Dual blockade of NEP and renin-angiotensin system was shown to have a complementary anti-hypertensive effect by BNP-induced natriuresis and suppressing salt sensitivity due to an increase in intrarenal Ang II concentration.
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| Academic Significance and Societal Importance of the Research Achievements |
現在上市されているNEP/アンジオテンシンII受容体阻害薬の有効性を検証。
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