| Project/Area Number |
21K17151
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 57060:Surgical dentistry-related
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| Research Institution | Fujita Health University |
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Principal Investigator |
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Project Status |
Completed (Fiscal Year 2023)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2023: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2022: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2021: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 放射線 / 4D-CT / バーチャル内視鏡 / 鼻咽腔閉鎖機能 / 口唇口蓋裂 |
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| Outline of Research at the Start |
軟口蓋の主要な機能として、声や食べ物が口から鼻に漏れないようにする「鼻咽腔閉鎖機能」が挙げられる。口唇口蓋裂患者では鼻咽腔閉鎖機能不全を生じることが知られており、これまで鼻咽腔内視鏡検査により評価されていた。研究者らが開発してきた時相を持つ３次元CT画像、すなわち「４次元CT画像（4D-CT）」を用いることで、鼻咽腔閉鎖運動を定量化し、口蓋裂に伴う鼻咽腔閉鎖機能の評価に応用可能か、検証する。
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| Outline of Final Research Achievements |
A patient with residual velopharyngeal insufficiency after speech therapy underwent surgery. Preoperative and postoperative 4D-CT imaging was performed, and the findings obtained from 4D-CT were compared with those from nasopharyngoscopy. The concordance rate between the two examinations was 63%.
In addition, 4D-CT imaging of the patients who had acquired normal articulation postoperatively was performed again, analyzed as data without velopharyngeal insufficiency, and compared with the preoperative images. No trend was found in the pre- and postoperative changes in soft palate length and soft palate thickness, but the soft palate elevation angle and the cross sectional area of nasopharyngeal closure dysfunction both showed improvement after surgery.
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| Academic Significance and Societal Importance of the Research Achievements |
これまで定性評価が中心であった口唇口蓋裂患者における鼻咽腔閉鎖機能の動態解析および定量化に成功した。さらなる症例の蓄積により、鼻咽腔閉鎖機能不全のメカニズム解明や、術式選択の基準制定に貢献しうることが期待される。
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