Maternal-fetal new communication via 'outer membrane vesicles' derived from periodontal pathogens.
Project/Area Number |
21K17211
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Research Category |
Grant-in-Aid for Early-Career Scientists
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Allocation Type | Multi-year Fund |
Review Section |
Basic Section 57080:Social dentistry-related
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Research Institution | Okayama University |
Principal Investigator |
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Project Period (FY) |
2021-04-01 – 2023-03-31
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Project Status |
Completed (Fiscal Year 2022)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2022: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2021: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Keywords | 骨格成長 / 母子口腔健康 / 歯周病 / 細胞外小胞 / 骨格形成 / 歯周病原菌 / 胎児発育 |
Outline of Research at the Start |
本研究の目的は,歯周病菌由来の「細胞外小胞」が母体の胎盤組織および胎児の骨格形成にどう関与するか,細胞・分子レベルで明らかにすることである. 具体的には,歯周病菌由来の「細胞外小胞」について以下のことを明らかにする. ① 胎盤に移行するか ② 胎盤組織にどのような影響を与えるか ③ 胎児の骨格形成や骨関連細胞の機能に影響するか
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Outline of Final Research Achievements |
During the embryonic period, the foetus exchanges nutrients, metabolites and gases with the maternal side via the 'placenta'. In recent years, maternal oral environment has been found to be involved in the growth and development of the foetus and the onset of disease, but the detailed mechanisms are unknown. This study focused on the effects of 'outer membrane vesicles' derived from periodontopathogenic bacteria on placental tissue. The results showed that 1) transferred to the placenta and foetus; and 2) inhibited placental tissue formation. Next, we would like to clarify the effects of the maternal-derived periodontopathogen-derived 'outer membrane vesicles' on the growth function of the offspring after birth.
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Academic Significance and Societal Importance of the Research Achievements |
本研究により、母体の口腔細菌叢と胎児の成長発育とを関連付ける因子として,歯周病菌由来の「細胞外小胞」が大きな役割を果たしていることが明らかとなった。母体胎盤の血管形成のみならず、胎児体格形成にも影響を与えることから、口腔細菌叢を中心とした口腔環境が母体だけではなく,生後の子の成長発育へ影響を与える可能性が十分に考えられる。本研究結果は歯科のみならず産科・小児科学的にも重要な意義を持つ。
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Report
(3 results)
Research Products
(19 results)
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[Journal Article] Maternal gut microbiome decelerates fetal endochondral bone formation by inducing inflammatory reaction.2022
Author(s)
Yoko Uchida-Fukuhara, Takako Hattori, Fu Shanqi, Sei Kondo, Miho Kuwahara, Daiki Fukuhara, Md Monirul Islam, Kota Kataoka, Daisuke Ekuni, Satoshi Kubota, Manabu Morita, Mika ikegame, Hirohiko Okamura
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Journal Title
Microorganisms
Volume: 1000
Issue: 5
Pages: 1-10
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] The Impact of Oral Health Behaviors, Health Belief Model, and Absolute Risk Aversion on the Willingness of Japanese University Students to Undergo Regular Dental Check-Ups: A Cross-Sectional Study2022
Author(s)
Ichiro Sumita, Naoki Toyama, Daisuke Ekuni, Takayuki Maruyama, Aya Yokoi, Daiki Fukuhara, Yoko Uchida-Fukuhara, Momoko Nakahara, Manabu Morita
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Journal Title
Int J Environ Res Public Health .
Volume: 19
Issue: 21
Pages: 13920-13920
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Vestigial-Like 3 Plays an Important Role in Osteoblast Differentiation by Regulating the Expression of Osteogenic Transcription Factors and BMP Signaling2022
Author(s)
Haoze Yuan, Mika Ikegame, Yoko Fukuhara, Fumiko Takemoto, Yaqiong Yu, Jumpei Teramachi, Yao Weng, Jiajie Guo, Daisuke Yamada, Takeshi Takarada, Ying Li, Hirohiko Okamura & Bin Zhang
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Journal Title
Calcif Tissue Int
Volume: 111
Issue: 3
Pages: 331-344
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Extracellular vesicles of P. gingivalis-infected macrophages induce lung injury.2021
Author(s)
Kayo Yoshida, Kaya Yoshida, Natsumi Fujiwara, Mariko Seyama, Kisho Ono, Hotaka Kawai, Jiajie Guo, Ziyi Wang, Yao Weng, Yaqiong Yu, Yoko Uchida-Fukuhara, Mika Ikegame, Akira Sasaki, Hitoshi Nagatsuka, Hiroshi Kamioka, Hirohiko Okamura, Kazumi Ozaki
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Journal Title
Biochim Biophys Acta - Molecular Basis of Disease
Volume: 1867
Issue: 11
Pages: 166236-166236
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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