• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

International comparative study on the actual conditions of polypharmacy using the real-world data

Research Project

Project/Area Number 21K17231
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 58010:Medical management and medical sociology-related
Research InstitutionInternational University of Health and Welfare

Principal Investigator

Park Jinsang  国際医療福祉大学, 福岡薬学部, 講師 (20749949)

Project Period (FY) 2021-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2023: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2022: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2021: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords医療リアルワールドデータ / 多剤併用 / ポリファーマシー / 向精神薬 / 国際比較
Outline of Research at the Start

高齢者を中心に薬剤の多剤併用が社会問題化しており、薬剤の多剤併用(ポリファーマシー)に対する注意喚起をしたガイドラインが近年発出されている。政策的介入に関しては診療報酬改定に伴い、ポリファーマシーを抑制するため複数の政策が施行されている。ただし、診療報酬改定により薬剤使用の適正化に向けた現行の取り組みが、臨床現場においてどのような効果を及ぼしているかに関しては十分な検討がなされていない。本研究は悉皆性の高いリアルワールドデータである電子カルテデータや全国レセプトデータを用いて、国内外のポリファーマシーの実態を定量的に評価し、政策介入と臨床側の処方変容の相関を総合評価する手法の確立案を検討する。

Outline of Final Research Achievements

In this study, we investigated polypharmacy, a growing social issue particularly among the elderly, using comprehensive real-world data such as electronic health records and national prescription data. Our objective was to quantitatively assess the prevalence of polypharmacy and to propose a methodology for a comprehensive evaluation of the correlation between healthcare policy interventions and changes in clinical prescribing patterns.
Specifically, we analyzed prescribing trends of psychotropic medications, including benzodiazepine receptor agonists, regional variations in polypharmacy, and the prescribing trends of psychotropic drugs to pediatric and adolescent populations. This study elucidated the impact of healthcare policy interventions, demonstrating the effectiveness of strategies aimed at reducing polypharmacy. These findings are expected to provide critical insights for the formulation of future healthcare policies and contribute to the enhancement of healthcare quality.

Academic Significance and Societal Importance of the Research Achievements

本研究は医療リアルワールドデータを基盤として、診療報酬の改定により薬剤使用の適正化に向けた現行の取り組みが、臨床現場においてどのような効果を及ぼしているかを明らかにし、薬剤の適正使用に資するエデンスを効率的に生み出すことに貢献することである。それに基づき多剤併用の概念を特定し、地域間の複雑なばらつきの要因構造と多剤併用の動向を定量化し、地域レベルに多剤併用の実態や政策的な取り組みに関する全体像を検討した。これらの成果は医療政策の立案者や医療提供者にとって、薬物使用の最適化に向けて検討できる基盤となり得る点において、社会的意義が高い。

Report

(4 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • Research Products

    (10 results)

All 2023 2022 2021

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 5 results) Presentation (4 results) (of which Int'l Joint Research: 4 results)

  • [Journal Article] Difference in the prevalence of hypertension and its risk factors depending on area-level deprivation in Japan2022

    • Author(s)
      Okui Tasuku、Park Jinsang
    • Journal Title

      BMC Research Notes

      Volume: 15 Issue: 1 Pages: 37-37

    • DOI

      10.1186/s13104-022-05931-6

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prescribing Trends Psychotropic Drugs Against Children and Adolescents and Association with Polypharmacy Reduction Policy for Psychotropic Drugs: Based on Japanese National Database Survey2022

    • Author(s)
      Park Jinsang、Okui Tasuku、Nakashima Naoki
    • Journal Title

      Studies in Health Technology and Informatics

      Volume: 290 Pages: 1132-1132

    • DOI

      10.3233/shti220303

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evaluation of the prescription amount of narcotic analgesics based on cancer pain relief management2022

    • Author(s)
      Park J
    • Journal Title

      European Journal of Public Health

      Volume: 32 Issue: Supplement_3 Pages: 525-525

    • DOI

      10.1093/eurpub/ckac131.281

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Analysis of regional differences in the amount of hypnotic and anxiolytic prescriptions in Japan using nationwide claims data2022

    • Author(s)
      Okui Tasuku、Park Jinsang
    • Journal Title

      BMC Psychiatry

      Volume: 22 Issue: 1 Pages: 44-44

    • DOI

      10.1186/s12888-021-03657-6

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Analysis of the regional difference in the number of multi-drug prescriptions and its predictors in Japan, 2015?20182021

    • Author(s)
      Okui Tasuku、Park Jinsang
    • Journal Title

      BMC Research Notes

      Volume: 14 Issue: 1 Pages: 367-367

    • DOI

      10.1186/s13104-021-05787-2

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Trends in the Prescription of Benzodiazepine Receptor Agonists from 2009 to 2020: A Retrospective Study Using Electronic Healthcare Record Data of a University Hospital in Japan2021

    • Author(s)
      Okui Tasuku、Park Jinsang、Hirata Akie、Nakashima Naoki
    • Journal Title

      Healthcare

      Volume: 9 Issue: 12 Pages: 1724-1724

    • DOI

      10.3390/healthcare9121724

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Quantitative Evaluation of Standardizations of Clinical Laboratory Examination Codes Based on Real-World Data from the Japanese Sentinel Project2023

    • Author(s)
      Jinsang Park
    • Organizer
      LMCE 2023 (Laboratory Medicine Congress & Exhibition) and the 64th KSLM Annual Meeting
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Evaluation of the prescription amount of narcotic analgesics based on cancer pain relief management2022

    • Author(s)
      Jinsang Park
    • Organizer
      The 15th European Public Health Conference
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] Prescribing trends psychotropic drugs against children and adolescents and association with polypharmacy reduction policy for psychotropic drugs: based on Japanese national database survey2021

    • Author(s)
      Jinsang Park, Tasuku Okui, Naoki Nakashima
    • Organizer
      The 18th World Congress of Medical and Health Informatics (Medinfo 2021, Virtual Conference)
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Trend analysis of prescription patterns of psychotropic drugs for elderly patients in Japan: A nationwide population-based study2021

    • Author(s)
      Jinsang Park, Tasuku Okui, Naoki Nakashima
    • Organizer
      ISPE's 13th Asian Conference on Pharmacoepidemiology and 28th Conference of Korea Society for Pharmacoepidemiology and Risk Management
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research

URL: 

Published: 2021-04-28   Modified: 2025-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi