The effect of polycyclic aromatic hydrocarbons, nitro-PAHs and meteorological conditions on atherosclerotic cardiovascular disease under influence of climate change and Asian Sand Dust

• Project/Area Number: 21K17267
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 58020:Hygiene and public health-related: including laboratory approach
• Research Institution: Asia Center for Air Pollution Research (2022-2023); Kanazawa University (2021)
• Principal Investigator: Pham Oanh 一般財団法人日本環境衛生センターアジア大気汚染研究センター, 情報管理部, 研究員 (10895816)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Project Status: Completed (Fiscal Year 2023)
• Budget Amount: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2023: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000); Fiscal Year 2022: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000); Fiscal Year 2021: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
• Keywords: Asian Dust / long-range transport / PAHs and nitro-PAHs / Health effect / Long-range transport / PAHs / N-PAHs / ASCVD / nitro-PAHs / Asian Sand Dust / climate change

Outline of Research at the Start

Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of morbidity and premature death globally. A cohort study in Shikamachi, Ishikawa Prefecture will be utilized to evaluate 10-year ASCVD risk for Japanese population and to find the influence of climate change and long-range transport of particulate matter (Asian Sand Dust) on ASCVD. The effect of temperature, relative humidity, solar radiation, atmospheric pressure, and polycylic aromatic hydrocarbons (PAHs) and nitro-PAHs concentrations on ASCVD admission in Japan will be determined.

Outline of Annual Research Achievements

今年度では、代表者は2020年から2021年にかけて、西日本（金沢、福岡、能登、福江）における黄砂と多環芳香族炭化水素（PAHs）およびニトロPAHsの長距離輸送と健康影響を調査した。 黄砂は西日本の環境中粒子状物質（APM）濃度を上昇させたが、総PAHおよびニトロPAH濃度は上昇させなかった。 APMの平均濃度は金沢で最も高かった（23.8±34.1μg/m3）。全PAHの平均濃度は福岡が最も高かった（0.76±0.84 ng/m3）。能登はすべての化合物の濃度が最も低く、福江は都市部（福岡市）と同等かそれ以上の濃度であった。さらに、冬季には能登と福江で大気汚染物質の濃度が上昇した。アジア大陸からの長距離輸送は、夏季を除く2年間で検出された。特に福江と能登では冬季の長距離輸送が顕著であった。西日本における黄砂とPAHsとニトロPAHsの長距離輸送は、輸送ルートと起源が異なることがわかった。この情報は、なぜAPMが異なる健康影響反応を引き起こすのかについて、より深い洞察を与える。勤務先が変わったため、代表者は金沢大学から提供された動脈硬化性心血管系のデータに接 続できなかった。そこで、黄砂とPAHsの一般的な健康影響を調査した。西日本のBaP_eq濃度は、BaP_eqの年間規制値1.0ng/m3よりはるかに低く、欧州の遠隔地のBaP_eq濃度（0.02ng/m3）に匹敵した。その結果、PAHsは鼻症状、成人日本人の喘息、慢性咳嗽患者のリスク増加と正の関係を示したが、黄砂のPM2.5は喘息に影響を及ぼさなかった。都市部（金沢市と福岡市）では、PM2.5に起因する症例数が多く、PAHsに起因する生涯追加がん症例数も農村部より多かった。しかし、福江では、人口10万人当たりのPM2.5によるリスク帰属症例数が都市部より多く、これは農村部でのLRTによる健康リスクを表している。

Research Products

• [Journal Article] Contributions of long-range transport from the Asian continent and local emissions on atmospheric PM2.5, polycyclic aromatic hydrocarbons, and their nitro-derivatives in Kanazawa and Noto Peninsula, Japan (2024)
  • Author(s): Hayakawa Kazuichi、Kim-Oanh Pham、Takami Akinori、Odajima Hiroshi、Nagato Edward G.、Hara Akinori、Nakamura Hiroyuki
  • Journal Title: Heliyon Volume: 10 Issue: 5 Pages: e27320-e27320
  • DOI: 10.1016/j.heliyon.2024.e27320
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Different Transport Behaviors between Asian Dust and Polycyclic Aromatic Hydrocarbons in Urban Areas: Monitoring in Fukuoka and Kanazawa, Japan (2022)
  • Author(s): Kim-Oanh Pham, Akinori Hara, Jiaye Zhao, Keita Suzuki, Atsushi Matsuki, Yayoi Inomata, Hiroshi Matsuzaki, Hiroshi Odajima, Kazuichi Hayakawa, Hiroyuki Nakamura
  • Journal Title: Applied Sciences Volume: 12(11) Issue: 11 Pages: 5404-5404
  • DOI: 10.3390/app12115404
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Longitudinal Study on the Association between Ambient Polycyclic Aromatic Hydrocarbons and Nasal Symptoms in Adult Japanese (2022)
  • Author(s): Jiaye Zhao, Akinori Hara, Kazuichi Hayakawa, Kim-Oanh Pham, Keita Suzuki, Hiromasa Tsujiguchi, Hiroshi Matsuzaki, Hiroshi Odajima, Akinori Takami, Hiroyuki Nakamura
  • Journal Title: Applied Sciences Volume: 12(24) Issue: 24 Pages: 12544-12544
  • DOI: 10.3390/app122412544
  • Peer Reviewed / Open Access
• [Journal Article] Association between cough and ambient polycyclic aromatic hydrocarbons in patients with chronic cough: an observational study in two regions of Japan (2022)
  • Author(s): Akinori Hara, Hiroshi Odajima, Hiroshi Matsuzaki, Masaki Fujimura, Tomoko Toma, Taizo Wada, Noriyuki Ohkura, JiaYe Zhao, Kim-Oanh Pham, Keita Suzuki, Hiromasa Tsujiguchi, Akinori Takami, Kazuichi Hayakawa, Hiroyuki Nakamura
  • Journal Title: Applied Sciences Volume: 12(24) Issue: 24 Pages: 12505-12505
  • DOI: 10.3390/app122412505
  • Peer Reviewed / Open Access
• [Journal Article] Analysis of Chemical Components of Fine Particulate Matter Observed at Fukuoka, Japan, in Spring 2020 and Their Transport Paths (2022)
  • Author(s): Ayako Yoshino, Akinori Takami, Atsushi Shimizu, Kei Sato, Kazuichi Hayakawa, Ning Tang, Kim-Oanh Pham, Akinori Hara, Hiroyuki Nakamura, Hiroshi Odajima
  • Journal Title: Applied Sciences Volume: 12(22) Issue: 22 Pages: 11400-11400
  • DOI: 10.3390/app122211400
  • Peer Reviewed / Open Access
• [Journal Article] The Role of Polygenic Susceptibility on Air Pollution-Associated Asthma between German and Japanese Elderly Women (2022)
  • Author(s): Sara Kress, Akinori Hara, Claudia Wigmann, Takehiro Sato, Keita Suzuki, Kim-Oanh Pham, Qi Zhao, Ashtyn Areal, Atsushi Tajima, Holger Schwender, Hiroyuki Nakamura, Tamara Schikowski
  • Journal Title: International Journal of Environmental Research and Public Health Volume: 19(16) Issue: 16 Pages: 9869-9869
  • DOI: 10.3390/ijerph19169869
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Combustion source apportionment and risk assessment in western side of Japan (2023)
  • Author(s): Kim-Oanh Pham
  • Organizer: 第64大気環境学会
• [Presentation] Effect of long-range transport on air pollution in rural and urban areas on the western side of Japan (2022)
  • Author(s): Kim-Oanh Pham
  • Organizer: The 63rd Annual Meeting of Japan Society for Atmospheric Environment
• [Presentation] Long-range transport in rural and urban areas on the western side of Japan (2022)
  • Author(s): Pham KO
  • Organizer: 10th International Conference on Acid Deposition
  • Int'l Joint Research
• [Presentation] Asian Sand Dust and its effect on polycyclic aromatic hydrocarbons in Fukuoka and Kanazawa (2022)
  • Author(s): Kim-Oanh Pham
  • Organizer: 4th Japan-Germany Symposium on Advanced Preventive Medicine
• [Presentation] Lifetime lung cancer risk due to polycyclic aromatic hydrocarbons during Asian Sand Dust season in Fukuoka and Kanazawa (2021)
  • Author(s): Oanh Pham
  • Organizer: 18th Annual Meeting of the Association for Preventive Medicine of Japan
• [Remarks]
  • URL: https://researchmap.jp/oanh-pham