The effect of polycyclic aromatic hydrocarbons, nitro-PAHs and meteorological conditions on atherosclerotic cardiovascular disease under influence of climate change and Asian Sand Dust
Project/Area Number |
21K17267
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Research Category |
Grant-in-Aid for Early-Career Scientists
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Allocation Type | Multi-year Fund |
Review Section |
Basic Section 58020:Hygiene and public health-related: including laboratory approach
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Research Institution | Asia Center for Air Pollution Research (2022) Kanazawa University (2021) |
Principal Investigator |
Pham Oanh 一般財団法人日本環境衛生センターアジア大気汚染研究センター, 情報管理部, 研究員 (10895816)
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Project Period (FY) |
2021-04-01 – 2024-03-31
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Project Status |
Granted (Fiscal Year 2022)
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Budget Amount *help |
¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2023: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2022: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2021: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
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Keywords | Health effect / Asian Dust / Long-range transport / PAHs / N-PAHs / ASCVD / nitro-PAHs / Asian Sand Dust / climate change |
Outline of Research at the Start |
Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of morbidity and premature death globally. A cohort study in Shikamachi, Ishikawa Prefecture will be utilized to evaluate 10-year ASCVD risk for Japanese population and to find the influence of climate change and long-range transport of particulate matter (Asian Sand Dust) on ASCVD. The effect of temperature, relative humidity, solar radiation, atmospheric pressure, and polycylic aromatic hydrocarbons (PAHs) and nitro-PAHs concentrations on ASCVD admission in Japan will be determined.
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Outline of Annual Research Achievements |
I found that long-range transport (LRT) of Asian Dust and LRT of polycyclic aromatic hydrocarbons (PAHs) on East Asia has different routes and origin. The information provides more insight on why the ambient particulate matter (APM) induces different health effect's reaction. K. O. Pham, A. Hara, J. Zhao, K. Suzuki, A. Matsuki, Y. Inomata, H. Matsuzaki, H. Odajima, K. Hayakawa, H. Nakamura, Different Transport Behaviors between Asian Dust and Polycyclic Aromatic Hydrocarbons in Urban Areas: Monitoring in Fukuoka and Kanazawa, Japan, Appl. Sci, 12(11), 5404-5404 (2022) The health effects from Asian Dust, and LRT of PAHs were investigated. The results showed that PAHs had positive relationship with increased risk of nasal symptoms, asthma in Adult Japanese, and Japanese patients with chronic cough, while PM2.5 had no effect on asthma. The future plan is to investigate the nitro-PAHs and hydroxy-PAHs concentrations in western Japan.
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Current Status of Research Progress |
Current Status of Research Progress
2: Research has progressed on the whole more than it was originally planned.
Reason
I changed my workplace in 2022, so there's delay in the progress. However, I was able to analyze sample and publish a paper. But I have to give up analyzing the effect of PAHs, nitro-PAHs on atherosclerotic cardiovascular disease (ASCV) due to personal data restriction.
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Strategy for Future Research Activity |
I plan to set up and analyze OH-PAHs.
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Report
(2 results)
Research Products
(9 results)
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[Journal Article] Different Transport Behaviors between Asian Dust and Polycyclic Aromatic Hydrocarbons in Urban Areas: Monitoring in Fukuoka and Kanazawa, Japan2022
Author(s)
Kim-Oanh Pham, Akinori Hara, Jiaye Zhao, Keita Suzuki, Atsushi Matsuki, Yayoi Inomata, Hiroshi Matsuzaki, Hiroshi Odajima, Kazuichi Hayakawa, Hiroyuki Nakamura
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Journal Title
Applied Sciences
Volume: 12(11)
Issue: 11
Pages: 5404-5404
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Association between cough and ambient polycyclic aromatic hydrocarbons in patients with chronic cough: an observational study in two regions of Japan2022
Author(s)
Akinori Hara, Hiroshi Odajima, Hiroshi Matsuzaki, Masaki Fujimura, Tomoko Toma, Taizo Wada, Noriyuki Ohkura, JiaYe Zhao, Kim-Oanh Pham, Keita Suzuki, Hiromasa Tsujiguchi, Akinori Takami, Kazuichi Hayakawa, Hiroyuki Nakamura
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Journal Title
Applied Sciences
Volume: 12(24)
Issue: 24
Pages: 12505-12505
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Analysis of Chemical Components of Fine Particulate Matter Observed at Fukuoka, Japan, in Spring 2020 and Their Transport Paths2022
Author(s)
Ayako Yoshino, Akinori Takami, Atsushi Shimizu, Kei Sato, Kazuichi Hayakawa, Ning Tang, Kim-Oanh Pham, Akinori Hara, Hiroyuki Nakamura, Hiroshi Odajima
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Journal Title
Applied Sciences
Volume: 12(22)
Issue: 22
Pages: 11400-11400
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] The Role of Polygenic Susceptibility on Air Pollution-Associated Asthma between German and Japanese Elderly Women2022
Author(s)
Sara Kress, Akinori Hara, Claudia Wigmann, Takehiro Sato, Keita Suzuki, Kim-Oanh Pham, Qi Zhao, Ashtyn Areal, Atsushi Tajima, Holger Schwender, Hiroyuki Nakamura, Tamara Schikowski
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Journal Title
International Journal of Environmental Research and Public Health
Volume: 19(16)
Issue: 16
Pages: 9869-9869
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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