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パーキンソン病での頸部感覚神経刺激リハビリにおける不顕性誤嚥との関連性の検証

Research Project

Project/Area Number 21K17512
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 59010:Rehabilitation science-related
Research InstitutionHiroshima University

Principal Investigator

中森 正博  広島大学, 医系科学研究科(医), 助教 (30881297)

Project Period (FY) 2021-04-01 – 2026-03-31
Project Status Granted (Fiscal Year 2023)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2025: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2024: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2023: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2022: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2021: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsパーキンソン病 / 頸部感覚神経刺激 / 不顕性誤嚥 / 嚥下障害 / リハビリテーション
Outline of Research at the Start

神経疾患では嚥下障害による肺炎のリスクが高く、『評価』と『リハビリ』を行って未然に防ぐ対策が重要である。現在、嚥下リハビリは嚥下関連筋の運動機能を中心に行われている。一方で肺炎は咽喉頭の感覚低下による不顕性誤嚥や咳嗽不全でも生じる。本研究は、頸部感覚神経電気刺激装置を用いて咽喉頭の感覚神経を賦活化させる機能を活用し、不顕性誤嚥の頻度が高いパーキンソン病患者において、咽喉頭の感覚神経と不顕性誤嚥の関連性、および本装置によって得られる効果を明らかにする。咳嗽の改善、肺炎発症率の低下が証明されれば、感覚神経が不顕性誤嚥に深く関与している事を示せるだけでなく、広く臨床現場での活用も期待できる。

Outline of Annual Research Achievements

本研究はパーキンソン病患者を対象に頸部感覚神経電気刺激を行う介入研究である。医療機器の適応外使用であることから、特定臨床研究として実施した。令和3年度に、特定臨床研究開始のために必要な諸準備を行い、「パーキンソン病での頸部感覚神経電気刺激リハビリにおける嚥下機能改善に関する単群介入研究」として広島大学病院倫理委員会に提出し、令和4年4月25日承認、jRCT公表を行った。対象はパーキンソン病患者で、介入は、頸部感覚神経電気刺激を1回20分、週2回、8週間実施した。介入終了後さらに8週間経過観察とし、評価は全過程(16週間)において4週間ごとに評価した。令和4年6月1日から症例登録を開始した。参加希望者が想定外に多く、登録が速やかに進み、令和5年6月30日に最終症例(27例目)の最終評価を終えた。医療機器に伴う有害事象は生じなかった。主要評価項目である1%クエン酸テスト正常者の割合が介入終了時に有意に増加した。副次評価項目としては、介入終了8週間後における、1%クエン酸咳テストの正常患者割合は改善、簡易1%クエン酸咳テスト正常者の割合が、介入終了時および介入終了8週間後で改善、嚥下状態(EAT-10)正常者の割合が、介入終了時および介入終了8週間後で改善、を認めた。介入終了時および介入終了8週間後における、嚥下造影時相解析による誤嚥および喉頭侵入率の減少は認められなかった。16週間の全観察期間における肺炎発症者はいなかった。探索的評価項目として、頸部多チャンネル筋電図、電子聴診器による嚥下音評価を入れており、それらのデータ解析も進めている。

Current Status of Research Progress
Current Status of Research Progress

1: Research has progressed more than it was originally planned.

Reason

特定臨床研究の諸準備、倫理審査での承認、jRCT公表は予定通り進行した。統計部門と行った症例数設計で、当初より登録症例が少数で完遂する見込みとなり、さらに、参加希望者が想定外に多く、登録が速やかに進んだ。そのため、令和5年6月30日に最終症例の最終フォローを終え、データ解析、成果の論文発表を残すのみとなった。登録を行った。データ解析も令和5年度中にほぼ終了し、論文報告を終えればすべて完遂する。全体を通して1年以上早く進展することとなった。

Strategy for Future Research Activity

最終登録症例の最終評価が完了し、データ解析もほぼ完了している。成果報告(学会発表、論文発表)の段階に入る。加えて、探索的評価項目のサブ解析とその成果報告も行う。

Report

(3 results)
  • 2023 Research-status Report
  • 2022 Research-status Report
  • 2021 Research-status Report
  • Research Products

    (28 results)

All 2024 2023 2022 2021 2020

All Journal Article (22 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 22 results,  Open Access: 17 results) Presentation (6 results) (of which Invited: 1 results)

  • [Journal Article] Prospective Observational Study for the Comparison of Screening Methods Including Tongue Pressure and Repetitive Saliva Swallowing With Detailed Videofluoroscopic Swallowing Study Findings in Patients With Acute Stroke2024

    • Author(s)
      Nakamori Masahiro、Imamura Eiji、Maetani Yuta、Yoshida Mitsuyoshi、Yoshikawa Mineka、Nagasaki Toshikazu、Masuda Shin、Kayashita Jun、Mizoue Tatsuya、Wakabayashi Shinichi、Maruyama Hirofumi、Hosomi Naohisa
    • Journal Title

      Journal of the American Heart Association

      Volume: 13 Issue: 3

    • DOI

      10.1161/jaha.123.032852

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between motor symptoms of Parkinson’s disease and swallowing disorders2024

    • Author(s)
      Nakamori Masahiro、Toko Megumi、Yamada Hidetada、Hayashi Yuki、Ushio Kai、Yoshikawa Kohei、Haruta Azusa、Hiraoka Aya、Yoshikawa Mineka、Nagasaki Toshikazu、Mikami Yukio、Maruyama Hirofumi
    • Journal Title

      Neurological Sciences

      Volume: 45 Issue: 5 Pages: 2021-2026

    • DOI

      10.1007/s10072-023-07238-1

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of neck percutaneous interferential current sensory stimulation on swallowing function in patients with Parkinson's disease: A single-arm, open-label study protocol2023

    • Author(s)
      Nakamori Masahiro、Toko Megumi、Yamada Hidetada、Hayashi Yuki、Yoshikawa Kohei、Yoshikawa Mineka、Nagasaki Toshikazu、Hiraoka Aya、Shimizu Yoshitaka、Mikami Yukio、Maruyama Hirofumi
    • Journal Title

      Contemporary Clinical Trials Communications

      Volume: 33 Pages: 101158-101158

    • DOI

      10.1016/j.conctc.2023.101158

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Swallowing sound evaluation using an electronic stethoscope and artificial intelligence analysis for patients with amyotrophic lateral sclerosis2023

    • Author(s)
      Nakamori Masahiro、Ishikawa Ruoyi、Watanabe Tomoaki、Toko Megumi、Naito Hiroyuki、Takahashi Tamayo、Simizu Yoshitaka、Yamazaki Yu、Maruyama Hirofumi
    • Journal Title

      Frontiers in Neurology

      Volume: 14 Pages: 1212024-1212024

    • DOI

      10.3389/fneur.2023.1212024

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Detailed findings of videofluoroscopic examination among patients with Parkinson's disease on the effect of cervical percutaneous interferential current stimulation2023

    • Author(s)
      Nakamori Masahiro、Toko Megumi、Yamada Hidetada、Hayashi Yuki、Haruta Azusa、Hiraoka Aya、Yoshikawa Mineka、Nagasaki Toshikazu、Ushio Kai、Yoshikawa Kohei、Shimizu Yoshitaka、Mikami Yukio、Maruyama Hirofumi
    • Journal Title

      Frontiers in Neurology

      Volume: 14 Pages: 1279161-1279161

    • DOI

      10.3389/fneur.2023.1279161

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Swallowing sound index analysis using electronic stethoscope and artificial intelligence for patients with Parkinson's disease2023

    • Author(s)
      Nakamori Masahiro、Shimizu Yoshitaka、Takahashi Tamayo、Toko Megumi、Yamada Hidetada、Hayashi Yuki、Ushio Kai、Yoshikawa Kohei、Hiraoka Aya、Yoshikawa Mineka、Nagasaki Toshikazu、Mikami Yukio、Maruyama Hirofumi
    • Journal Title

      Journal of the Neurological Sciences

      Volume: 454 Pages: 120831-120831

    • DOI

      10.1016/j.jns.2023.120831

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Peak expiratory flow, but not tongue pressure, can predict pneumonia development in older adults2023

    • Author(s)
      Kamimura Teppei、Nakamori Masahiro、Naito Hiroyuki、Aoki Shiro、Nezu Tomohisa、Imamura Eiji、Mizoue Tatsuya、Wakabayashi Shinichi、Masuda Takeshi、Hattori Noboru、Maruyama Hirofumi、Hosomi Naohisa
    • Journal Title

      European Geriatric Medicine

      Volume: 14 Issue: 1 Pages: 211-217

    • DOI

      10.1007/s41999-023-00744-7

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Immediate and 6-month seizure outcomes following first and second SARS-CoV2 mRNA vaccinations: A multicenter study with a nationwide survey2023

    • Author(s)
      Nonaka Megumi、Neshige Shuichiro、Yamada Hidetada、Ishibashi Haruka、Takebayashi Yoshiko、Nakamori Masahiro、Aoki Shiro、Yamazaki Yu、Shishido Takeo、Agari Dai、Ochi Kazuhide、Iida Koji、Maruyama Hirofumi
    • Journal Title

      Epilepsy & Behavior

      Volume: 139 Pages: 109070-109070

    • DOI

      10.1016/j.yebeh.2022.109070

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Are patients with Parkinson's disease at a lower risk of catching the common cold? Propensity score matching2023

    • Author(s)
      Neshige Shuichiro、Aoki Shiro、Nezu Tomohisa、Nakamori Masahiro、Yamazaki Yu、Ohshita Tomohiko、Maruyama Hirofumi
    • Journal Title

      Parkinsonism & Related Disorders

      Volume: 106 Pages: 105227-105227

    • DOI

      10.1016/j.parkreldis.2022.11.019

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Isolated Neurohypophysial Sarcoidosis Involving the Cavernous Sinus Mimicking a Malignant Tumor2022

    • Author(s)
      Yasuyuki Kinoshita, Akira Taguchi, Fumiyuki Yamasaki, Masahiro Nakamori, Vishwa Jeet Amatya, Koji Iida
    • Journal Title

      NMC Case Report Journal

      Volume: 9 Issue: 0 Pages: 31-35

    • DOI

      10.2176/jns-nmc.2021-0296

    • ISSN
      2188-4226
    • Year and Date
      2022-12-31
    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Progressive Multifocal Leukoencephalopathy in Relapsed Ph+ Acute Lymphoblastic Leukemia after Cord Blood Transplantation and Blinatumomab Treatment: A Case Report and Literature Review2022

    • Author(s)
      Edahiro Taro、Fukushima Noriyasu、Otani Tatsuya、Nakamori Masahiro、Nakamichi Kazuo、Chishaki Ren、Fujino Keita、Mino Tatsuji、Yoshida Tetsumi、Sugihara Sayaka、Nishizawa Masatoshi、Ichinohe Tatsuo
    • Journal Title

      Acta Haematologica

      Volume: 145 Issue: 6 Pages: 655-661

    • DOI

      10.1159/000526132

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Diffusion-Weighted Imaging Hyperintensities in Acute and Subacute-Phase Intracerebral Hemorrhage2022

    • Author(s)
      Shiga Yuji、Aoki Shiro、Tasaka Saki、Takeshita Jun、Kamimura Teppei、Hara Naoyuki、Shimomura Ryo、Matsushima Hayato、Nakamori Masahiro、Nezu Tomohisa、Imamura Eiji、Mizoue Tatsuya、Wakabayashi Shinichi、Maruyama Hirofumi
    • Journal Title

      Journal of Stroke and Cerebrovascular Diseases

      Volume: 31 Issue: 8 Pages: 106549-106549

    • DOI

      10.1016/j.jstrokecerebrovasdis.2022.106549

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical Factors Predicting Voluntary Driving Cessation among Patients with Parkinson’s Disease2022

    • Author(s)
      Yamada Hidetada、Nakamori Masahiro、Nezu Tomohisa、Kotozaki Teppei、Kitamura Juri、Ohshita Tomohiko、Sueda Yoshimasa、Maruyama Hirofumi
    • Journal Title

      Behavioural Neurology

      Volume: 2022 Pages: 1-6

    • DOI

      10.1155/2022/4047710

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of ankle-brachial index with cognitive decline in patients with lacunar infarction2022

    • Author(s)
      Nakamori Masahiro、Matsushima Hayato、Tachiyama Keisuke、Hayashi Yuki、Imamura Eiji、Mizoue Tatsuya、Wakabayashi Shinichi
    • Journal Title

      PLOS ONE

      Volume: 17 Issue: 2 Pages: e0263525-e0263525

    • DOI

      10.1371/journal.pone.0263525

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Assessment of Serum IgG Titers to Various Periodontal Pathogens Associated with Atrial Fibrillation in Acute Stroke Patients2022

    • Author(s)
      Nezu Tomohisa、Hosomi Naohisa、Aoki Shiro、Nishi Hiromi、Nakamori Masahiro、Shiga Yuji、Imamura Eiji、Shintani Tomoaki、Kawaguchi Hiroyuki、Maruyama Hirofumi
    • Journal Title

      Journal of Stroke and Cerebrovascular Diseases

      Volume: 31 Issue: 3 Pages: 106301-106301

    • DOI

      10.1016/j.jstrokecerebrovasdis.2021.106301

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Amyloid Beta Is Internalized via Macropinocytosis, an HSPG- and Lipid Raft-Dependent and Rac1-Mediated Process2022

    • Author(s)
      Keyoumu Nazere, Tetsuya Takahashi, Naoyuki Hara, Kazuki Muguruma, Masahiro Nakamori, Yu Yamazaki, Hiroyuki, Morino Hirofumi, Maruyama
    • Journal Title

      Frontiers in Molecular Neuroscience

      Volume: - Pages: 804702-804702

    • DOI

      10.3389/fnmol.2022.804702

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Characteristics and Prognostic Factors of Swallowing Dysfunction in Patients with Lateral Medullary Infarction2021

    • Author(s)
      Hara Naoyuki、Nakamori Masahiro、Ayukawa Tomoko、Matsushima Hayato、Hayashi Yuki、Imamura Eiji、Mizoue Tatsuya、Wakabayashi Shinichi
    • Journal Title

      Journal of Stroke and Cerebrovascular Diseases

      Volume: 30 Issue: 12 Pages: 106122-106122

    • DOI

      10.1016/j.jstrokecerebrovasdis.2021.106122

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Relationship between tongue pressure and dysphagia diet in patients with acute stroke2021

    • Author(s)
      Nakamori Masahiro、Ishikawa Kenichi、Imamura Eiji、Yamamoto Haruna、Kimura Keiko、Ayukawa Tomoko、Mizoue Tatsuya、Wakabayashi Shinichi
    • Journal Title

      PLOS ONE

      Volume: 16 Issue: 6 Pages: e0252837-e0252837

    • DOI

      10.1371/journal.pone.0252837

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] External cervical resorption detected via cone‐beam computed tomography in a patient with myelin oligodendrocyte glycoprotein antibody-associated disease: A case report2021

    • Author(s)
      Munenaga Syuichi、Usuda Momoko、Ouhara Kazuhisa、Maetani Yuta、Kajiya Mikihito、Matsuda Shinji、Furusho Hisako、Miyauchi Mutsumi、Nakamori Masahiro、Maruyama Hirofumi、Nishi Hiromi、Kawaguchi Hiroyuki
    • Journal Title

      Clinical Case Reports

      Volume: 9 Issue: 7 Pages: 7-7

    • DOI

      10.1002/ccr3.4415

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Utility of Magnetic Resonance Spectroscopy for the Progression of Neurological Symptoms in Lenticulostriate Artery Territory Infarction.2021

    • Author(s)
      Shiga Y, Nezu T, Nakamori M, Hosomi N, Akiyama Y, Tachiyama K, Kamimura T, Kinoshita N, Hayashi Y, Matsushima H, Imamura E, Aoki S, Ueno H, Ohshita T, Wakabayashi S, Yamasaki F, Awai K, Maruyama H.
    • Journal Title

      J Stroke Cerebrovasc Dis.

      Volume: 30 Issue: 6 Pages: 105747-105747

    • DOI

      10.1016/j.jstrokecerebrovasdis.2021.105747

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of anatomical variations on ultrasonographic reference values of lower extremity peripheral nerves2021

    • Author(s)
      Kuga Junichiro、Hironaka Akemi、Ochi Kazuhide、Sugimoto Takamichi、Nakamori Masahiro、Nezu Tomohisa、Maruyama Hirofumi
    • Journal Title

      Muscle & Nerve

      Volume: 63 Issue: 6 Pages: 890-896

    • DOI

      10.1002/mus.27238

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] cnm-Positive Streptococcus mutans and diffusion-weighted imaging hyperintensities in acute intracerebral hemorrhage2020

    • Author(s)
      Yuji Shiga, Shiro Aoki, Naohisa Hosomi, Ryota Nomura, Masahiro Nakamori, Tomohisa Nezu, Keisuke Tachiyama, Teppei Kamimura, Naoto Kinoshita, Ryo Shimomura, Yuki Hayashi, Hayato Matsushima, Eiji Imamura, Hiroki Ueno, Shinichi Wakabayashi, Kazuhiko Nakano, Tatsuo Kohriyama, Hirofumi Maruyama
    • Journal Title

      Eur J Neurol .

      Volume: - Issue: 5 Pages: 1581-1589

    • DOI

      10.1111/ene.14725

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 筋萎縮性側索硬化症患者における電子聴診AI解析を用いた嚥下音の検討2023

    • Author(s)
      中森正博, 石川若芸, 渡邉友彬, 都甲めぐみ, 内藤裕之, 高橋珠世, 向井明里, 清水慶隆, 丸山博文
    • Organizer
      第64回日本神経学会学術集会
    • Related Report
      2023 Research-status Report
  • [Presentation] 舌圧、Peak Expiratory Flowを用いた高齢者肺炎予測因子の検討2023

    • Author(s)
      中森正博, 上村鉄兵, 内藤裕之, 青木志郎, 祢津智久, 今村栄次, 益田武, 服部登, 丸山博文, 細見直永
    • Organizer
      第65回日本老年医学会学術集会
    • Related Report
      2023 Research-status Report
  • [Presentation] パーキンソン病患者における頸部多チャンネル表面筋電図による運動単位の解析と電気刺激による効果の検討2023

    • Author(s)
      中森正博, 吉川浩平, 都甲めぐみ, 山田英忠, 吉川峰加, 長﨑信一, 丸山博文
    • Organizer
      第29回日本摂食嚥下リハビリテーション学会学術大会
    • Related Report
      2023 Research-status Report
  • [Presentation] シンポジウム9「神経筋エコーの新たな試み」舌と嚥下機能のエコー評価2021

    • Author(s)
      中森正博
    • Organizer
      第40回日本脳神経超音波学会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 初発ラクナ梗塞患者のcerebral microbleedsと認知機能の検討2021

    • Author(s)
      中森正博 , 細見直永 , 上村鉄兵 , 林有紀 , 今村栄次 , 若林伸一 , 丸山博文
    • Organizer
      第40回日本認知症学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] 神経超音波の併用が診断、治療に有用であった神経痛性筋萎縮症の59歳男性例2021

    • Author(s)
      中森正博 , 山田英忠 , 久賀淳一朗 , 廣中明美 , 杉本太路 , 丸山 博文
    • Organizer
      第51回日本臨床神経生理学会学術大会
    • Related Report
      2021 Research-status Report

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Published: 2021-04-28   Modified: 2024-12-25  

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