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Biomechanical assessment of the treatment for knee joint injury and development of novel treatment procedure

Research Project

Project/Area Number 21K18054
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 90110:Biomedical engineering-related
Research InstitutionOsaka University

Principal Investigator

Yamakawa Satoshi  大阪大学, 大学院医学系研究科, 特任研究員(常勤) (40816740)

Project Period (FY) 2021-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2022: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2021: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords関節外傷 / 膝関節 / 前十字靭帯 / 半月板 / 膝関節外傷 / 半月板損傷 / 生体医工学
Outline of Research at the Start

本研究では,前十字靱帯(ACL)損傷の治療で行われる解剖学的ACL再建術が,いかに正常ACLの力学特性を再現しているかを,ACLのひずみ-力学応答解析を用いてに明らかにする.ACLの解剖学的特徴を模倣する現行治療法のコンセプトにおいて,再建ACLのひずみ-力学応答から得られる荷重伝達機能の再現度合いは,より正常なACLに近づけるための生体力学的再建法の確立に貢献する.また,半月板損傷に行われる半月板の縫合方法が,繰り返し荷重に対する縫合部の安定性と膝関節運動に与える影響を明らかにし,膝関節の2大外傷であるACL損傷と半月損傷に対して生体力学的に,より優れた治療法への貢献を目指す.

Outline of Final Research Achievements

In the present study, the current treatment procedures were biomechanically assessed. In the treatment of meniscus injuries, several techniques were compared based on the stability of the repaired site as an index, and the points of improvement of the current treatment procedure were clarified. In the treatment of anterior cruciate ligament injuries, new findings were obtained regarding the mechanical properties of the tissue used in the treatment. These findings were obtained through direct and quantitative assessment of clinical procedures, and can be directly fed back to clinicians.

Academic Significance and Societal Importance of the Research Achievements

関節外傷の治療では,生体組織の解剖学的な特徴を模倣する解剖学的外科治療が一般的に行われている.それらに対して本研究では,定量的なデータで治療の評価を行い,バイオメカニクス的データを基に現行治療法の課題を明らかにした.これらのデータは,現行治療法の改善に重要なデータであるだけでなく,解剖学的外科治療を生体力学的外科治療へとステップアップさせるための第一歩ともいえる.今後,この考え方が広まり,生体力学的に考案された治療法が開発され,関節外傷外科治療のレベルが一段と向上することが期待される.

Report

(3 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • Research Products

    (11 results)

All 2023 2022 2021

All Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 1 results) Presentation (8 results) (of which Int'l Joint Research: 4 results)

  • [Journal Article] 膝蓋腱の骨―腱移行部角度(ACL再建術におけるGraft bending angle)が引張特性に与える影響2023

    • Author(s)
      山川 学志,史野 根生,大堀 智毅,辻井 聡,中田 研
    • Journal Title

      臨床バイオメカニクス

      Volume: 44

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 半月板横断裂に対する部分切除による半月板内縁欠損は半月板の変形と逸脱を増大させる2023

    • Author(s)
      山川 学志,小笠原 一生,辻井 聡,大堀 智毅,近田 彰治,佐藤 世羅,金本 隆司,中田 研
    • Journal Title

      臨床バイオメカニクス

      Volume: 44

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Placement of sutures for inside-out meniscal repair: both sutures through meniscal tissue reduces displacement on cyclical loading.2021

    • Author(s)
      Yamakawa S, Mae T, Ogasawara I, Hirose T, Konda S, Nakata K.
    • Journal Title

      J Orthop Exp

      Volume: 8 Issue: 1 Pages: 94-94

    • DOI

      10.1186/s40634-021-00417-z

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Loss of the meniscal inner part by partial meniscectomy for radial meniscal tear increases the meniscal deformation and extrusion2023

    • Author(s)
      Satoshi Yamakawa, Tomoki Ohori, Issei Ogasawara, Akira Tsujii, Shoji Konda, Seira Sato, Takashi Kanamoto, Ken Nakata
    • Organizer
      Orthopaedic Research Society Annual Meeting2023
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] PARTIAL MENISCECTOMY OF THE MENISCAL INNER PART INCREASES THE MENISCAL DEFORMATION AND EXTRUSION2023

    • Author(s)
      Satoshi Yamakawa, Tomoki Ohori, Issei Ogasawara, Akira Tsujii, Shoji Konda, Seira Sato, Takashi Kanamoto, Ken Nakata
    • Organizer
      Summer Biomechanics, Bioengineering and Biotransport Conference
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 骨片つき膝蓋腱の屈曲角度(ACL再建術におけるGraft bending angle)が引張特性に与える影響2022

    • Author(s)
      山川 学志,史野 根生,大堀 智毅,辻井 聡,中田 研
    • Organizer
      第49回日本臨床バイオメカニクス学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 半月板横断裂に対する部分切除による半月板内縁欠損は半月板の変形と逸脱を増大させる2022

    • Author(s)
      山川 学志,小笠原 一生,辻井 聡,大堀 智毅,近田 彰治,佐藤 世羅,金本 隆司,中田 研
    • Organizer
      第49回日本臨床バイオメカニクス学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 受動的屈曲伸展運動下における半月縫合部の安定性評価2022

    • Author(s)
      ○山川 学志,前 達雄,小笠原 一生,廣瀬 毅人,近田 彰治,中田 研
    • Organizer
      第49回日本臨床バイオメカニクス学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Comparison of the anterior cruciate ligament function between human and quadrupedal animals2022

    • Author(s)
      Satoshi Yamakawa, Daisuke Suzuki, Tatsuo Mae, Hiromichi Fujie, Ken Nakata
    • Organizer
      9th World Congress of Biomechanics
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Stitching through mid-substance region of meniscus for the repair of longitudinal meniscal tear prevents widening of the stitched part after cyclic loading2022

    • Author(s)
      Satoshi Yamakawa, Tatsuo Mae, Issei Ogasawara, Takehito Hirose, Shoji Konda, Ken Nakata
    • Organizer
      Orthopaedic Research Society Annual Meeting 2022
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] 半月縫合術における縫合部位が術後安定性に及ぼす影響2021

    • Author(s)
      山川 学志,前 達雄,小笠原 一生,廣瀬 毅人,近田 彰治,中田 研
    • Organizer
      第48回臨床バイオメカニクス学会
    • Related Report
      2021 Research-status Report

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Published: 2021-04-28   Modified: 2024-01-30  

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