| Budget Amount *help |
¥26,000,000 (Direct Cost: ¥20,000,000、Indirect Cost: ¥6,000,000)
Fiscal Year 2023: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2022: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2021: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
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| Outline of Final Research Achievements |
In this study, we aimed to identify genes that regulate osteoimmune cell differentiation and function by employing CRISPR/Cas9 screening. Based on in sillico and in vitro analysis, we identified a novel transcription factor that regulates osteoclast differentiation. We determined the enhancer regions that regulate RANKL expression and validated them using genetically modified mice to elucidate the physiological and pathological significance of the each of RANKL enhancers. This study has further advanced our understanding of osteoimmunology and led to the development of new therapeutic strategies.
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