| Budget Amount *help |
¥25,740,000 (Direct Cost: ¥19,800,000、Indirect Cost: ¥5,940,000)
Fiscal Year 2024: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2023: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2022: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2021: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Outline of Final Research Achievements |
This study aimed to elucidate the neural mechanisms underlying stuttering, a speech disorder, by testing the basal ganglia loop dysfunction hypothesis using songbirds as an animal model. Specifically, we investigated the involvement of dopamine receptors by selectively knocking down D1R and D2R in the song-related basal ganglia nucleus (Area X) via adeno-associated viral vectors, and analyzed vocal behavior in detail. While no significant changes were observed in the number of syllable repetitions, alterations were found in the transition probabilities of chunk structures, along with a decrease in entropy. These results suggest that dopaminergic signaling within the basal ganglia plays a crucial role in the control of phoneme sequences even after the vocal learning period.
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