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The development of diagnostic tool for autism spectrum disorder by AI construction

Research Project

Project/Area Number 21K18365
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 2:Literature, linguistics, and related fields
Research InstitutionAomori Chuo Gakuin University

Principal Investigator

Kato Sumi  青森中央学院大学, 経営法学部, 教授 (80311504)

Co-Investigator(Kenkyū-buntansha) 斉藤 まなぶ  弘前大学, 保健学研究科, 教授 (40568846)
田中 真寿美  青森中央学院大学, 経営法学部, 准教授 (90557795)
乙木 百合香  東北大学, 農学研究科, 助教 (90812834)
Project Period (FY) 2021-07-09 – 2025-03-31
Project Status Completed (Fiscal Year 2024)
Budget Amount *help
¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2023: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2022: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
KeywordsASD / NLP / machine learning / SFL / diagnostic assessment / lexicogrammar / 神経発達症 / neurocognitive functions / Autism Spectrum Disorder / Pragmatic Impairment / pragmatic impairment / 自閉症スペクトラム障害 / 自然言語処理 / コーパス言語学 / 語用論的障害 / 機械学習
Outline of Research at the Start

ASDの語用論的障害が特定の認知機能不全からきていて、認知神経学との関連で議論されなければならないことが、臨床分野では議論されてきている。そこで本研究では、言語学からの知見として、ASDの語用論的障害が、語彙-文法資源のどこに生じるのかを、コーパスを基にした大量のデータから、精緻なマッピングによって提示する。このマッピングを機械学習によって、ASDと定型発達の判別を試行させ、診断ツールとしての可能性をパイロット・スタディとしてまとめる。

Outline of Final Research Achievements

This study aimed to develop a novel diagnostic support model for adolescents and adults with autism spectrum disorder (ASD), taking into account the diversity of symptoms observed in this population and the limitations of existing diagnostic tools, including the ADOS-2. By applying machine learning to a corpus of ASD and non-ASD speech annotated based on systemic functional linguistics theory, the study demonstrated that a deep neural network (DNN) model achieved high classification performance (accuracy: 80%, precision: 82%, sensitivity: 73%, specificity: 87%). In particular, the pragmatic features observed in the interview task were found to play a decisive role in diagnostic classification.

Academic Significance and Societal Importance of the Research Achievements

本研究は、自然発話における語彙文法的選択に基づいてASDと非ASDを識別するという世界初の試みとして高い診断的有効性を示した。従来の表層的特徴や感情音声、話者情報に依拠する研究とは異なり、本研究は意味構造に着目した文法的特徴に基づく診断補助の枠組みを構築し、臨床言語学と機械学習の融合により、青年・成人期のASDにおける言語的特性の客観的・高精度な識別を実現した。これは診断の信頼性向上に貢献するのみならず、将来的な実用化によって医療・教育現場における早期支援や誤診防止にも寄与し、社会的インパクトも大きい。

Report

(5 results)
  • 2024 Annual Research Report   Final Research Report ( PDF )
  • 2023 Research-status Report
  • 2022 Research-status Report
  • 2021 Research-status Report
  • Research Products

    (35 results)

All 2025 2024 2023 2022 2021

All Journal Article (23 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 15 results,  Open Access: 16 results) Presentation (10 results) (of which Int'l Joint Research: 5 results,  Invited: 2 results) Book (2 results)

  • [Journal Article] 日本語学習支援者養成において『やさしい日本語』の表現力を高めるタスクのあり方2025

    • Author(s)
      佐藤香織・田中真寿美
    • Journal Title

      人文論究

      Volume: 94 Pages: 99-105

    • Related Report
      2024 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 令和6年度 文部科学省委託事業「児童生徒の実態把握のためのネットワーク構築に向けた調査研究」 散在地域4県における「外国につながる児童生徒の教育支援に関するアンケート調査」報告書  『散在地域における多文化多言語の子どもの教育支援の充実に向けて』2025

    • Author(s)
      吉田美穂・内海由美子・早瀬郁子・村元治・石塚ゆかり・田中真寿美
    • Journal Title

      -

      Volume: - Pages: 175-180

    • Related Report
      2024 Annual Research Report
  • [Journal Article] Nondestructive determination of canola oil oxidation causes: A near-infrared spectroscopy coupled with liquid chromatography-mass spectrometry for analyzing triacylglycerol hydroperoxide isomers2025

    • Author(s)
      Otoki Yurika、Ishikawa Daitaro、Kato Shunji、Kusumoto Ibuki、Ozaki Yukihiro、Nakagawa Kiyotaka
    • Journal Title

      Food Chemistry

      Volume: 467 Pages: 142143-142143

    • DOI

      10.1016/j.foodchem.2024.142143

    • Related Report
      2024 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lexicogrammatical Choices and Cognitive Patterns in Autism Spectrum Disorder: Insights from Self-Other Differentiation and Sense of Agency2024

    • Author(s)
      Kato Sumi
    • Journal Title

      Forum for Linguistic Studies

      Volume: 6 Issue: 6 Pages: 326-346

    • DOI

      10.30564/fls.v6i6.7263

    • Related Report
      2024 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Creating a diagnostic assessment model for autism spectrum disorder by differentiating lexicogrammatical choices through machine learning2024

    • Author(s)
      Kato Sumi、Hanawa Kazuaki、Saito Manabu、Nakamura Kazuhiko
    • Journal Title

      PLOS ONE

      Volume: 19 Issue: 9 Pages: 0311209-0311209

    • DOI

      10.1371/journal.pone.0311209

    • Related Report
      2024 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 発達健診でのWebスクリーニングシステムの活用2024

    • Author(s)
      斉藤まなぶ
    • Journal Title

      子どものこころと脳の発達

      Volume: 15 Pages: 46-53

    • Related Report
      2024 Annual Research Report
  • [Journal Article] Effects of Different Manufacturing Processes on Thermal and Photo-oxidative Stability of Sesame Oil2024

    • Author(s)
      Rahmania Halida、Nakanishi Tomomi、Oi Satomi、Onishi Rika、Yamagami Eiichiro、Yamane Kazuyuki、Otoki Yurika、Kato Shunji、Nakagawa Kiyotaka
    • Journal Title

      Journal of Oleo Science

      Volume: 73 Issue: 10 Pages: 1267-1276

    • DOI

      10.5650/jos.ess24084

    • ISSN
      1345-8957, 1347-3352
    • Related Report
      2024 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Preparation of saturated fatty acid hydroperoxide isomers and determination of their thermal decomposition products ? 2-alkanones and lactones2024

    • Author(s)
      Aoyagi Kanji、Kato Shunji、Isaka Daisuke、Sekiguchi Yoshinori、Otoki Yurika、Uehara Hidetaka、Nakagawa Kiyotaka
    • Journal Title

      Food Chemistry: X

      Volume: 21 Pages: 101074-101074

    • DOI

      10.1016/j.fochx.2023.101074

    • Related Report
      2024 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Induction of ferroptosis in human keratinocyte HaCaT cells by squalene hydroperoxide: Possible prevention of skin ferroptosis by botanical extracts2024

    • Author(s)
      Kato Chikara、Kusumoto Ibuki、Kato Shunji、Otoki Yurika、Ito Junya、Totsuka Hirono、Rajgopal Arun、Hong Jina、Nakagawa Kiyotaka
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 698 Pages: 149553-149553

    • DOI

      10.1016/j.bbrc.2024.149553

    • Related Report
      2024 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Comparison of the Catabolic Rates of Linoleic and Oleic Acid Hydroperoxides Using <sup>13</sup>CO<sub>2</sub> Expired from Mice2024

    • Author(s)
      Yoshinaga-Kiriake Aya、Yoshinaga Kazuaki、Miyagawa Sae、Yoshino Kanako、Tanaka Seiya、Takahashi Takumi、Kato Shunji、Ito Junya、Otoki Yurika、Nakagawa Kiyotaka、Gotoh Naohiro
    • Journal Title

      Journal of Oleo Science

      Volume: 73 Issue: 6 Pages: 847-855

    • DOI

      10.5650/jos.ess23236

    • ISSN
      1345-8957, 1347-3352
    • Related Report
      2024 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 日本語学習支援者養成において『やさしい日本語』で表現する力をどう育てるか-日本語レベルが異なる学習者との対話経験の重要性2024

    • Author(s)
      田中真寿美・佐藤香織
    • Journal Title

      人文論究

      Volume: 93 Pages: 27-34

    • Related Report
      2023 Research-status Report
    • Open Access
  • [Journal Article] DCDの就学前(保育所・幼稚園・こども園)の気づきと支援2023

    • Author(s)
      斉藤まなぶ
    • Journal Title

      チャイルドヘルス

      Volume: 25

    • DOI

      10.3389/fped.2024.1332723

    • Related Report
      2024 Annual Research Report 2023 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparative analysis of mean length of utterance and lexical density in individuals with and without autism spectrum disorder2023

    • Author(s)
      Kato S
    • Journal Title

      The annual report of ACGU regional management institute

      Volume: 20

    • Related Report
      2023 Research-status Report
    • Open Access
  • [Journal Article] Attitudinal evaluation of autism spectrum disorder individuals from the perspective of affordances and social cognition2023

    • Author(s)
      加藤澄
    • Journal Title

      機能言語学研究

      Volume: 12

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Epidemiology of ASD in Preschool-age Children in Japan2022

    • Author(s)
      Saito M, Sakamoto Y and Terui A.
    • Journal Title

      IntechOpen

      Volume: - Pages: 1-14

    • DOI

      10.5772/intechopen.108674

    • ISBN
      9781837683420, 9781837683437
    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 大学生は外国につながる子どもの学習支援活動にいかに取り組んだか2022

    • Author(s)
      田中真寿美
    • Journal Title

      青森中央学院大学地域マネジメント研究所研究年報

      Volume: 19

    • Related Report
      2022 Research-status Report
  • [Journal Article] Toward mapping pragmatic impairment of autism spectrum disorder individuals through the development of a corpus of spoken Japanese2022

    • Author(s)
      Kato, S., Hanawa, K., Linh, V. P., Saito, M., Iimura, R., Inui, K., & Nakamura, K.
    • Journal Title

      PLoS One

      Volume: 17(2) Issue: 2 Pages: e0264204-e0264204

    • DOI

      10.1371/journal.pone.0264204

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Two Patients with Schizophrenia Treated with Clozapine Developed Neutropenia After Receiving a COVID-19 Vaccine.2022

    • Author(s)
      Tomita T, Sakamoto Y, Saito M, Hashimoto K, Ono Y, Nakamura K.
    • Journal Title

      International medical case reports journal

      Volume: 15 Pages: 29-33

    • DOI

      10.2147/imcrj.s350879

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 『日本語学習支援ネットワーク会議2021 in 青森』報告2022

    • Author(s)
      田中真寿美、鹿嶋彰
    • Journal Title

      青森中央学院大学地域マネジメント研究所研究年報

      Volume: 18

    • Related Report
      2021 Research-status Report
  • [Journal Article] How Neurodevelopment and Joint Attention Affects the Use of the Negotiating particles, ne and y2021

    • Author(s)
      Sumi Kato
    • Journal Title

      The Japanese Journal of Systemic Functional Linguistics

      Volume: 11 Pages: 11-30

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cohort Profile: The Assessment from Preschool to Puberty? Longitudinal Epidemiological (APPLE) study in Hirosaki, Japan2021

    • Author(s)
      Hirota, T., Adachi, M., Takahashi, M., Mori, H., Shinkawa, H., Sakamoto, Y., Saito, M., & Nakamura, K.
    • Journal Title

      International Journal of Epidemiology

      Volume: 50 Issue: 6 Pages: 1782-1783

    • DOI

      10.1093/ije/dyab112

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 「総説」発達障害児の早期発見・早期支援への取組~多領域連携による発達障害児支援システムの構築について~2021

    • Author(s)
      町田 徳子,斉藤 まなぶ
    • Journal Title

      特別支援教育研究

      Volume: 769

    • Related Report
      2021 Research-status Report
  • [Journal Article] 日本語未0プログラムと支援の実際2021

    • Author(s)
      田中真寿美
    • Journal Title

      令和3年度文部科学省委託事業「多文化共生に向けた日本語指導の充実に関する調査研究」報告書

      Volume: ー Pages: 171-174

    • Related Report
      2021 Research-status Report
  • [Presentation] Relationship between Sleep Problems and Morning Blood Melatonin Levels in 5-Year-Old ASD Children.2024

    • Author(s)
      A. Terui, M. Saito, Y. Sakamoto, A. Osato, T. Mikami and K. Nakamura.
    • Organizer
      INSAR
    • Related Report
      2024 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Differences in WISC-Ⅳ Profiles between Children with ASD and without ASD Pre- and Post- COVID-19 Pandemic.2024

    • Author(s)
      Y. Sakamoto, M. Saito, A. Osato, A. Terui, T. Mikami and K. Nakamura
    • Organizer
      INSAR
    • Related Report
      2024 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 自閉スペクトラム症を有する5歳児におけるフリン効果2024

    • Author(s)
      坂本由唯、斉藤まなぶ、照井藍、大里絢子、中村和彦.
    • Organizer
      日本児童青年精神医学会総会
    • Related Report
      2024 Annual Research Report
  • [Presentation] 発達性協調運動障害児の初期運動発達マイルストーンの獲得の特徴2023

    • Author(s)
      小枝周平、斉藤まなぶ、三上美咲、三上珠希、照井藍、坂本由唯、佐藤ちひろ、山田順子
    • Organizer
      第6回日本DCD学会
    • Related Report
      2023 Research-status Report
  • [Presentation] Creation of a new scale Screening for Social Development-14 (SSD-14) for early detection of neurodevelopmental disorders in 3-year-old children and social implementation of its web system2023

    • Author(s)
      Manabu Saito, A Osato, Y Sakamoto, A Terui, T Mikami, K Nakamura
    • Organizer
      The 11th Congress of The Asian Society for Child and Adolescent Psychiatry and Allied Professions(
    • Related Report
      2023 Research-status Report
    • Int'l Joint Research
  • [Presentation] Prevalence and Cumulative Incidence of Autism Spectrum Disorders in a community sample of Preschoolers in Japan2023

    • Author(s)
      Manabu Saito, Tomoya Hirota, Yui Sakamoto
    • Organizer
      The 11th Congress of The Asian Society for Child and Adolescent Psychiatry and Allied Professions(
    • Related Report
      2023 Research-status Report
    • Int'l Joint Research
  • [Presentation] Estimating the Prevalence of Autism Spectrum Disorders in 3-Year-Old Children in Community-Based Survey in 5-Year-Old Children, Including the Use of Web Systems2022

    • Author(s)
      M. Saito, T. Mikami, A. Terui, Y. Sakamoto, A. Osato, M. Takahashi, M Adachi, T. Hirota, K. Nakamura
    • Organizer
      INSAR 2022 Virtual Annual Meeting
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] 乳幼児期におけるDCD児の診察について~健診現場での問診や観察のポイント2022

    • Author(s)
      斉藤まなぶ
    • Organizer
      第6回日本DCD学会学術集会シンポジウム2
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] 発達障害児の早期発見・早期介入~地域での取組2022

    • Author(s)
      斉藤まなぶ
    • Organizer
      第16回日本小児心身医学会東北地方会学術集会特別講演
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] 日本語0パッケージ「想定される日本語指導の計画」の改訂2021

    • Author(s)
      田中真寿美
    • Organizer
      令和3年度文部科学省委託事業「多文化共生に向けた日本語指導の充実に関する調査研究」事業報告会
    • Related Report
      2021 Research-status Report
  • [Book] プライマリ・ケアに求められる 発達障害の診かたと向き合い方2024

    • Author(s)
      斉藤まなぶ
    • Total Pages
      186
    • Publisher
      金芳堂
    • ISBN
      9784765320047
    • Related Report
      2024 Annual Research Report
  • [Book] 発達障がい―病態から支援まで―2022

    • Author(s)
      大阪大学大学院連合小児発達学研究科(監修)
    • Total Pages
      168
    • Publisher
      朝倉書店
    • ISBN
      9784254301250
    • Related Report
      2022 Research-status Report

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Published: 2021-07-13   Modified: 2026-01-16  

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