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Creation of autonomous microfluidic processors

Research Project

Project/Area Number 21K18840
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 27:Chemical engineering and related fields
Research InstitutionUniversity of Tsukuba

Principal Investigator

Suzuki Hiroaki  筑波大学, 数理物質系, 教授 (20282337)

Project Period (FY) 2021-07-09 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2023: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2022: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2021: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsマイクルフルイディクス / 自立的送液制御 / 毛細管現象 / 電気化学 / ポリピロールバルブ / 亜鉛 / 微小櫛型電極 / 水素 / マイクロフルイディクス / バルブ / ポンプ / 水素バブル / 銀 / 電気化学回路 / ポリジメチルシロキサン / 溶液操作 / ポリピロール / 双方向送液 / 金属接続
Outline of Research at the Start

マイクロフルイディクスは化学分析や細胞工学の効率化に有望な技術であるが、現状のデバイス内での溶液操作は外部装置に依存している。本研究では、電気化学的原理に基づくバルブ、ポンプ、および溶液間の金属接続等の要素技術を基礎として電気化学回路を構成し、自立的に逐次動作を行い、溶液を処理する機構を実現する。また、これを化学/バイオセンシングや人工生命体を目指したアクチュエータの駆動に応用する。

Outline of Final Research Achievements

Microfluidic devices to realize autonomous solution transport were fabricated. In realizing sophisticated autonomous microfluidic devices, it is effective to use modular structures. In a type of device, movement of solutions by capillary action was controlled using a hydrophobic patch valve that changes its wettability upon the application of a potential. The valve was formed by electropolymerizing pyrrole in the presence of a surfactant. The potential was applied by injecting an electrolyte solution into a control flow channel and wetting a zinc electrode formed there and connected to the patch valve in the main flow channel. In another type of device, hydrogen bubbles produced and shrunk on platinum black interdigitated electrodes were used to move a solution in a flow channel forward and backward. The bubbles were produced by coupling the reaction with the oxidation of zinc in a control flow channel and were shrunk by coupling the reaction with the reduction of silver ions.

Academic Significance and Societal Importance of the Research Achievements

微小なチップ上で化学分析を行う微小化学分析システム(μTAS)や化学実験室を微小なチップ上に実現するLab-on-a-Chipの研究開発が活発に進められている。ここでは、μL~pLの微量の溶液の定量、移動、混合等の操作が必要となるが、現状では、これらの操作はマイクロシリンジポンプ等の装置を用いて行われている。ここで、これらの操作をチップ上の構成要素だけで自立的に行うことができれば、μTASの高度化が実現される。また、現在研究が活発化しつつあるソフトロボットを駆動させるためのマイクロフルイディクプロセッサを実現させるための基礎となりうる。

Report

(4 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • Research Products

    (5 results)

All 2023 2021

All Presentation (5 results) (of which Int'l Joint Research: 3 results,  Invited: 2 results)

  • [Presentation] Bipolar electrochemistry for microfabricated sensing devices of the next generation2023

    • Author(s)
      Hiroaki Suzuki
    • Organizer
      2023 International Conference on Smart Sensors (ICSS 2023)
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Electrochemical Circuits for Autonomous Microfluidic Solution Processing2021

    • Author(s)
      Chengrui Ma, Yusei Satoh, Hiroaki Suzuki
    • Organizer
      18th International Meeting on Chemical Sensors
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] 電気化学回路による自立的マイクロフルイディクデバイスの構築2021

    • Author(s)
      椎名瞳、馬成睿、楊昊、丁翰林、鈴木博章
    • Organizer
      2021年 電気化学秋季大会 (第69回化学センサ研究発表会)
    • Related Report
      2021 Research-status Report
  • [Presentation] Towards Autonomous Microfluidics2021

    • Author(s)
      Hiroaki Suzuki
    • Organizer
      2021 International Conference on Smart Sensors
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Electrochemical Circuits for Advanced Microfluidic Solution Processing2021

    • Author(s)
      Hanlin Ding, Hao Yang, Chengrui Ma, and Hiroaki Suzuki
    • Organizer
      第38回「センサ・マイクロマシンと応用システム」シンポジウム
    • Related Report
      2021 Research-status Report

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Published: 2021-07-13   Modified: 2025-01-30  

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