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Synthesis and medical application of deep ultraviolet persistent nanophosphors

Research Project

Project/Area Number 21K18942
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 32:Physical chemistry, functional solid state chemistry, and related fields
Research InstitutionNational Institute for Materials Science

Principal Investigator

SUN Hong-tao  国立研究開発法人物質・材料研究機構, 国際ナノアーキテクトニクス研究拠点, 主幹研究員 (30571822)

Co-Investigator(Kenkyū-buntansha) 山崎 智彦  国立研究開発法人物質・材料研究機構, 機能性材料研究拠点, 主幹研究員 (50419264)
Project Period (FY) 2021-07-09 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2022: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2021: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Keywordsナノ粒子 / 深紫外残光 / 長残光蛍光ナノ粒子 / 深紫外長残光
Outline of Research at the Start

本提案の鍵は、我々が世界で初めて合成に成功したUVC長残光蛍光粒子の医療応用にある。当該粒子はX線励起下でそのフォトンエネルギーを貯蔵した。そのエネルギーをUVC光に変換して励起停止後も数時間にわたって放射する特性を有する。それゆえ、がんなどの悪性腫瘍に当該粒子を摂取させれば、短時間のX線照射にも関わらず、長時間のUVC光照射により腫瘍細胞を死滅させることができると構想する。本研究では、UVC長残光放射特性をもつナノ粒子の合成、がん細胞を識別し特異吸着する表面リガンド開発、in-vitro及びin-vivo条件下でのUVC照射によるがん治療効果の検証まで研究を進める。

Outline of Final Research Achievements

The synthesis of Pr3+-doped Cs2NaYF6 double perovskite nanoparticles showing deep ultraviolet afterglow has been investigated. The hot-injection approach was adopted for the synthesis, and the detailed synthetic parameters affecting the size distribution and photophysical properties of nanoparticles were thoroughly investigated. In particular, the parameters governing the optical properties were examined and determined. Additionally, the structure and morphology of these nanoparticles were investigated. The obtained particles showed deep ultraviolet afterglow after charging by X-rays. It has been found that the surface ligand of nanoparticles can greatly affect the deep ultraviolet afterglow because of strong absorption of ligands in this spectral range. Removing the surface ligands greatly boost the intensity of deep ultraviolet afterglow, which benefits the medical application.

Academic Significance and Societal Importance of the Research Achievements

可視-近赤外波長域では、既に超残光蛍光体が報告されているが、深紫外波長域において超残光特性を示すナノ蛍光体は、現時点で世に存在しない。本研究成果は、深紫外超残光ナノ蛍光体がソフトケミストリーアプローチによって合成できることを実証した点で学術的意義が高く、医療応用への道が拓かれたと考える。今後研究を深化させ開発する「深紫外光放射ナノ粒子を活用した深紫外エミッション増強放射線療法」は、現行の放射線療法に革命を起こす可能性を秘めている点で社会的意義が高い。

Report

(3 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • Research Products

    (8 results)

All 2023 2022 2021

All Journal Article (8 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 8 results,  Open Access: 3 results)

  • [Journal Article] Fabrication of Super‐Sized Metal Inorganic‐Organic Hybrid Glass with Supramolecular Network via Crystallization‐Suppressing Approach2023

    • Author(s)
      Ali Mohamed A.、Winters Wessel M. W.、Mohamed Moushira A.、Tan Dezhi、Zheng Guojun、Madsen Rasmus S. K.、Magdysyuk Oxana V.、Diaz‐Lopez Maria、Cai Biao、Gong Nan、Xu Yijue、Hung Ivan、Gan Zhehong、Sen Sabyasachi、Sun Hong‐Tao、Bennett Thomas D.、Liu Xiaofeng、Yue Yuanzheng、Qiu Jianrong
    • Journal Title

      Angewandte Chemie

      Volume: 135 Issue: 14

    • DOI

      10.1002/ange.202218094

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Impact of coherent core/shell architecture on fast response in InP-based quantum dot photodiodes2023

    • Author(s)
      Nemoto Kazuhiro、Watanabe Junpei、Yamada Hiroyuki、Sun Hong-Tao、Shirahata Naoto
    • Journal Title

      Nanoscale Advances

      Volume: 5 Issue: 3 Pages: 907-915

    • DOI

      10.1039/d2na00734g

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Postproduction Approach to Enhance the External Quantum Efficiency for Red Light-Emitting Diodes Based on Silicon Nanocrystals2022

    • Author(s)
      Yamada Hiroyuki、Watanabe Junpei、Nemoto Kazuhiro、Sun Hong-Tao、Shirahata Naoto
    • Journal Title

      Nanomaterials

      Volume: 12 Issue: 23 Pages: 4314-4314

    • DOI

      10.3390/nano12234314

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Coherent InP/ZnS core@shell quantum dots with narrow-band green emissions2022

    • Author(s)
      Nemoto Kazuhiro、Watanabe Junpei、Sun Hong-Tao、Shirahata Naoto
    • Journal Title

      Nanoscale

      Volume: 14 Issue: 27 Pages: 9900-9909

    • DOI

      10.1039/d2nr02071h

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Water-Soluble Silicon Quantum Dots toward Fluorescence-Guided Photothermal Nanotherapy2022

    • Author(s)
      Ozbilgin Irem Nur Gamze、Yamazaki Tomohiko、Watanabe Junpei、Sun Hong-Tao、Hanagata Nobutaka、Shirahata Naoto
    • Journal Title

      Langmuir

      Volume: 38 Issue: 17 Pages: 5188-5196

    • DOI

      10.1021/acs.langmuir.1c02326

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Advances and Challenges in Tin Halide Perovskite Nanocrystals2021

    • Author(s)
      Chen Jia-Kai、Zhang Bin-Bin、Liu Qi、Shirahata Naoto、Mohammed Omar F.、Bakr Osman M.、Sun Hong-Tao
    • Journal Title

      ACS Materials Letters

      Volume: 3 Issue: 11 Pages: 1541-1557

    • DOI

      10.1021/acsmaterialslett.1c00444

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Phosphatidylcholine-mediated regulation of growth kinetics for colloidal synthesis of cesium tin halide nanocrystals2021

    • Author(s)
      Wang Lu-Ming、Chen Jia-Kai、Zhang Bin-Bin、Liu Qi、Zhou Yang、Shu Jie、Wang Zuoshan、Shirahata Naoto、Song Bo、Mohammed Omar F.、Bakr Osman M.、Sun Hong-Tao
    • Journal Title

      Nanoscale

      Volume: 13 Issue: 39 Pages: 16726-16733

    • DOI

      10.1039/d1nr04618g

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Silicon Quantum Dots for Light-Emitting Diodes Extending to the NIR-II Window2021

    • Author(s)
      Watanabe Junpei、Yamada Hiroyuki、Sun Hong-Tao、Moronaga Taku、Ishii Yasushi、Shirahata Naoto
    • Journal Title

      ACS Applied Nano Materials

      Volume: 4 Issue: 11 Pages: 11651-11660

    • DOI

      10.1021/acsanm.1c02223

    • Related Report
      2021 Research-status Report
    • Peer Reviewed

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Published: 2021-07-13   Modified: 2024-01-30  

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