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Construction of the RNA-binding molecule discovery system for RNA-targeted drug discovery

Research Project

Project/Area Number 21K19038
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 37:Biomolecular chemistry and related fields
Research InstitutionTohoku University

Principal Investigator

Nagatsugi Fumi  東北大学, 多元物質科学研究所, 教授 (90208025)

Project Period (FY) 2021-07-09 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2022: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2021: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords蛍光指示薬競合置換アッセイ / RNA高次構造 / バーコードマイクロアレイ / ハイスループット検索システム / RNA結合蛍光分子 / RNA / 大規模解析 / 結合分子 / 高次構造 / 蛍光性分子
Outline of Research at the Start

RNA標的創薬は次世代の医薬品創製として非常に注目を集めている。しかし、RNAの多様な構造から標的RNAのみを選択的に認識し強く結合する必要があり、優れたRNA結合低分子の報告例は限られている。本研究では、バーコードマイクロアレイ技術を利用しRNA結合蛍光性分子のRNA親和性に関する大規模結合情報データベースを構築、さらに、蛍光指示薬競合置換アッセイを用いてその情報を活用したデータ駆動型の新規RNA結合分子探索システムを構築し、新しいRNA結合分子の創製を目指す。本研究で提案する技術は、RNA高次構造及び結合分子両方向からの探索が可能であり、蛍光指示薬に対し莫大な情報を容易に取得できる。

Outline of Final Research Achievements

In this study, we examined the development of a methodology that combines our barcode microarray method with a fluorescent indicator competitive displacement (FID) assay in order to construct a high-throughput search system for RNA-binding small molecules. First, a fluorescent indicator was fixed on the solid support and mixed with a library of RNA having higher-order structure. The RNA sequences to which small molecules bound were separated and applied to a DNA microarray to obtain affinity information of fluorescent molecules for RNA. We selected the disease-related RNAs from the obtained affinity information, and the binding molecules for the target RNAs were searched from the compound library by FID assay. As a result, we found that the hit compounds binding to the target RNA differ depending on the using fluorescent indicator.

Academic Significance and Societal Importance of the Research Achievements

蛍光指示薬置換アッセイは核酸に結合する小分子を探索する方法論として非常に有効である。しかし、RNAに結合し、蛍光強度が変化する蛍光指示薬の報告例は限られている。本研究で開発した技術はRNA高次構造及び小分子両方向からのハイスループット探索が可能であり、蛍光指示薬に対して、莫大な情報を容易に取得できる。さらに得られる莫大な情報はRNA結合分子探索を飛躍的に発展させると期待され、社会的意義も非常に高い。本研究の進展は、RNA研究に大きなブレークスルーを起こすと考えられ、創薬科学、生命情報科学、核酸化学、生化学など様々な分野へも大きなインパクトを与えると考えている。

Report

(3 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • Research Products

    (67 results)

All 2023 2022 2021 Other

All Journal Article (11 results) (of which Peer Reviewed: 11 results,  Open Access: 2 results) Presentation (50 results) (of which Int'l Joint Research: 11 results,  Invited: 6 results) Book (3 results) Remarks (1 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Formation of Direction-Controllable Pseudorotaxane and Catenane Using Chemically Cyclized Oligodeoxynucleotides and Their Noncovalent RNA Labeling2023

    • Author(s)
      Kuwahara Kazuki、Yajima Sayaka、Yamano Yuuhei、Nagatsugi Fumi、Onizuka Kazumitsu
    • Journal Title

      Bioconjugate Chemistry

      Volume: - Pages: 696-706

    • DOI

      10.1021/acs.bioconjchem.3c00031

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of 6-Alkynylated Purine-Containing DNA via On-Column Sonogashira Coupling and Investigation of Their Base-Pairing Properties2023

    • Author(s)
      Okamura Hidenori、Trinh Giang Hoang、Dong Zhuoxin、Fan Wenjue、Nagatsugi Fumi
    • Journal Title

      Molecules

      Volume: 28 Issue: 4 Pages: 1766-1766

    • DOI

      10.3390/molecules28041766

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] <i>o</i>-Nitrobenzyl Oxime Ethers Enable Photoinduced Cyclization Reaction to Provide Phenanthridines under Aqueous Conditions2023

    • Author(s)
      Okamura Hidenori、Iida Momoka、Kaneyama Yui、Nagatsugi Fumi
    • Journal Title

      Organic Letters

      Volume: 25 Issue: 3 Pages: 466-470

    • DOI

      10.1021/acs.orglett.2c04015

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reactivity Modulation of Reactive OFF?ON Type G-Quadruplex Alkylating Agents2022

    • Author(s)
      Chen Yutong、Onizuka Kazumitsu、Hazemi Madoka E.、Nagatsugi Fumi
    • Journal Title

      Bioconjugate Chemistry

      Volume: 33 Issue: 11 Pages: 2097-2102

    • DOI

      10.1021/acs.bioconjchem.2c00458

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Photochemical Labeling of Nucleic Acid by Photocatalyst Tethered DNA Probe2022

    • Author(s)
      Yamano Yuuhei、Onizuka Kazumitsu、Sasaki Madoka、Sato Shinichi、Nagatsugi Fumi
    • Journal Title

      Chemistry Letters

      Volume: 51 Issue: 12 Pages: 1121-1124

    • DOI

      10.1246/cl.220397

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Selective Chemical Modification to the Higher‐Order Structures of Nucleic Acids2022

    • Author(s)
      Nagatsugi Fumi、Onizuka Kazumitsu
    • Journal Title

      The Chemical Record

      Volume: 23 Issue: 2

    • DOI

      10.1002/tcr.202200194

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hybridization-specific chemical reactions to create interstrand crosslinking and threaded structures of nucleic acids2022

    • Author(s)
      Onizuka Kazumitsu、Yamano Yuuhei、Abdelhady Ahmed Mostafa、Nagatsugi Fumi
    • Journal Title

      Organic & Biomolecular Chemistry

      Volume: 20 Issue: 23 Pages: 4699-4708

    • DOI

      10.1039/d2ob00551d

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of a selective ligand for G-G mismatches of CGG repeat RNA inducing the RNA structural conversion from the G-quadruplex into a hairpin-like structure2022

    • Author(s)
      Murase Hirotaka, Nagatsugi Fumi, Sasaki Shigeki
    • Journal Title

      Organic & Biomolecular Chemistry

      Volume: 20 Issue: 16 Pages: 3375-3381

    • DOI

      10.1039/d2ob00279e

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Selective and stable base pairing by alkynylated nucleosides featuring a spatially-separated recognition interface2022

    • Author(s)
      Okamura Hidenori、Trinh Giang Hoang、Dong Zhuoxin、Masaki Yoshiaki、Seio Kohji、Nagatsugi Fumi
    • Journal Title

      Nucleic Acids Research

      Volume: 50 Issue: 6 Pages: 3042-3055

    • DOI

      10.1093/nar/gkac140

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rapid Alkene-Alkene Photo-Cross-Linking on the Base-Flipping-Out Field in Duplex DNA2022

    • Author(s)
      Abdelhady Ahmed Mostafa、Onizuka Kazumitsu、Ishida Kei、Yajima Sayaka、Mano Eriko、Nagatsugi Fumi
    • Journal Title

      The Journal of Organic Chemistry

      Volume: 87 Issue: 5 Pages: 2267-2276

    • DOI

      10.1021/acs.joc.1c01498

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Synthesis of crosslinked 2′-OMe RNA duplexes and their application for effective inhibition of miRNA function2021

    • Author(s)
      Abdelhady Ahmed Mostafa、Hirano Yu、Onizuka Kazumitsu、Okamura Hidenori、Komatsu Yasuo、Nagatsugi Fumi
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 48 Pages: 128257-128257

    • DOI

      10.1016/j.bmcl.2021.128257

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Presentation] Large-scale analysis of RNA alkylation using OFF-ON type alkylators2023

    • Author(s)
      Yutong Chen, Kazumitsu Onizuka, Kaoru R. Komatsu, Emi Miyashita, Hirohide Saito, Fumi Nagatsugi
    • Organizer
      日本化学会 第103春季年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Development of reactive OFF-ON type alkylating agents based on pyrimidine structure2023

    • Author(s)
      Pingyun Lan, Kazumitsu Onizuka, Yutong Chen, Fumi Nagatsugi
    • Organizer
      日本化学会 第103春季年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 光触媒導入DNAプローブを利用した核酸光修飾法の開発2023

    • Author(s)
      山野雄平・鬼塚和光・佐々木まどか・佐藤伸一・永次史
    • Organizer
      日本化学会 第103春季年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 擬ロタキサンおよびカテナン形成能を持つ新規環状化核酸の開発2023

    • Author(s)
      桑原和貴・鬼塚和光・矢島さやか・山野雄平・永次史
    • Organizer
      日本化学会 第103春季年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] RNA-蛍光指示薬間相互作用大規模情報を利用したRNA結合分子スクリーニング2022

    • Author(s)
      長澤瞭佑、鬼塚和光、小松リチャード馨、宮下映見、小澤眞美子、齊藤博英、永次史
    • Organizer
      日本ケミカルバイオロジー学会 第16回年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] DNA結合タンパク質の選択的な光近接ラベル化(Selective light-based proximity labeling of DNA-interacting proteins)2022

    • Author(s)
      Ahmed Mostafa Abdelhady, Kazumitsu Onizuka, Tatsuki Masuzawa, Shinichi Sato, Keita Nakane, Takanori Oyoshi, Fumi Nagatsugi
    • Organizer
      日本核酸医薬学会 第7回年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 機能性オリゴヌクレオチドの開発2022

    • Author(s)
      永次 史
    • Organizer
      日本核酸医薬学会 第7回年会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] RNA-蛍光指示薬間相互作用大規模解析とRNA結合分子探索2022

    • Author(s)
      鬼塚和光、長澤瞭佑、小松リチャード馨、宮下映見、岩田遼平、小澤眞美子、齊藤博英、永次史
    • Organizer
      第16回バイオ関連化学シンポジウム
    • Related Report
      2022 Annual Research Report
  • [Presentation] 光触媒修飾DNAプローブを利用した核酸の光修飾法の開発2022

    • Author(s)
      山野雄平・鬼塚和光・佐々木まどか・佐藤伸一・永次史
    • Organizer
      第16回バイオ関連化学シンポジウム
    • Related Report
      2022 Annual Research Report
  • [Presentation] Development of novel threaded structure-forming nucleic acids with the ability of slipping direction control and their mechanism elucidation2022

    • Author(s)
      Kazuki Kuwahara, Kazumitsu Onizuka, Sayaka Yajima, Yuuhei Yamano, Fumi Nagatsugi
    • Organizer
      令和4年度化学系学協会東北大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Creation of novel fluorescent indicators for screening of RNA binding small molecules2022

    • Author(s)
      Ryohei Iwata, Kazumitsu Onizuka, Ryosuke Nagasawa, Hirotaka Murase, Fumi Nagatsugi
    • Organizer
      令和4年度化学系学協会東北大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] スリッピング方向が制御可能な貫通構造形成核酸の開発とそのメカニズム解明2022

    • Author(s)
      桑原和貴・鬼塚和光・矢島さやか・山野雄平・永次史
    • Organizer
      第12回 CSJ化学フェスタ2022
    • Related Report
      2022 Annual Research Report
  • [Presentation] Development of a screening system for RNA-binding small molecules based on large-scale information of interactions between RNAs and a fluorescence indicator2022

    • Author(s)
      長澤瞭佑、鬼塚和光、小松リチャード馨、宮下映見、小澤眞美子、齊藤博英、永次史
    • Organizer
      CBI学会2022年大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Pseudorotaxane and catenane formation via the slipping process2022

    • Author(s)
      Kazumitsu Onizuka, Kazuki Kuwahara, Sayaka Yajima, Yuuhei Yamano, Fumi Nagatsugi
    • Organizer
      ISNAC2022
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Selective photo-catalytic proximity labeling of G4 DNAinteracting proteins for the interaction proteomes of G4 DNA2022

    • Author(s)
      Ahmed Mostafa Abdelhady, Kazumitsu Onizuka, Tatsuki Masuzawa, Shinichi Sato, Keita Nakane, Takanori Oyoshi, Fumi Nagatsugi
    • Organizer
      ISNAC2022
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Nucleic acids modification by photo-catalytic reaction2022

    • Author(s)
      Yuuhei Yamano, Kazumitsu Onizuka, Madoka Sasaki, Shinichi Sato, and Fumi Nagatsugi
    • Organizer
      ISNAC2022
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Alkylation of G4 nucleic acids by reactive off-on type reagents and application2022

    • Author(s)
      Yutong Chen, Kazumitsu Onizuka, Madoka E. Hazemi, Emi Miyashita, Kaoru R. Komatsu, Hirohide Saito, Fumi Nagatsugi
    • Organizer
      第22回東北大学多元物質科学研究所研究発表会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Photocatalytic profiling of G4 DNA-interacting proteins2022

    • Author(s)
      Ahmed Mostafa Abdelhady, Kazumitsu Onizuka, Shinichi Sato, Tatsuki Masuzawa, Takanori Oyoshi, Fumi Nagatsugi
    • Organizer
      日本化学会 第103春季年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 光感受性オキシム構造を用いた生体適合性の光誘起型環化反応の開発2022

    • Author(s)
      岡村 秀紀、飯田 百香、金山 唯、永次 史
    • Organizer
      日本化学会 第102春季年会
    • Related Report
      2021 Research-status Report
  • [Presentation] DACN-MMCと3-アジドクマリンを用いた生体分子の蛍光標識化2022

    • Author(s)
      林原 智也、河崎 悠也、鬼塚 和光、井川 和宣、永次 史、友岡 克彦
    • Organizer
      日本化学会 第102春季年会
    • Related Report
      2021 Research-status Report
  • [Presentation] RNA結合大規模情報に基づいた新規蛍光指示薬の創製2022

    • Author(s)
      岩田 遼平、鬼塚 和光、長澤 瞭佑、村瀬 裕貴、永次 史
    • Organizer
      日本化学会 第102春季年会
    • Related Report
      2021 Research-status Report
  • [Presentation] Synthesis and cross-link properties of 2-amino-6-vinyl-7-deazapurine-deoxyriboside for anti-miRNA therapy2022

    • Author(s)
      Nadya Syahla Soemawisastra, Hidenori Okamura, Fumi Nagatsugi
    • Organizer
      日本化学会 第102春季年会
    • Related Report
      2021 Research-status Report
  • [Presentation] Development of novel OFF-ON type alkylating reagents2022

    • Author(s)
      Yutong Chen, Kazumitsu Onizuka, Pingyun Lan, Fumi Nagatsugi
    • Organizer
      日本化学会 第102春季年会
    • Related Report
      2021 Research-status Report
  • [Presentation] Selective photo-labeling of G4 DNA-binding protein2022

    • Author(s)
      AHMED MOSTAFA ABDELHADY, Kazumitsu Onizuka, Tatsuki Masuzawa, Shinichi Sato, Takanori Oyoshi, Fumi Nagatsugi
    • Organizer
      日本化学会 第102春季年会
    • Related Report
      2021 Research-status Report
  • [Presentation] Nucleic Acids Chemistry beyond the Watson-Crick Double Helix (76) : Structure-based Chemical Modification of Berberine to Improve the RNA Binding Property2022

    • Author(s)
      Sagar Satpathi, Tamaki Endoh, Yutong Chen, Saki Matsumoto, Tatsuya Ohyama, Peter Podbev, Janez Plavec, Kazumitsu Onizuka, Fumi Nagatsugi, Naoki Sugimoto
    • Organizer
      日本化学会 第102春季年会
    • Related Report
      2021 Research-status Report
  • [Presentation] CGGリピートRNAの構造変換を誘起する1,3-diazaphenoxazine誘導体の開発2022

    • Author(s)
      村瀬 裕貴、永次 史、佐々木 茂貴
    • Organizer
      日本薬学会 第142年会
    • Related Report
      2021 Research-status Report
  • [Presentation] RNA-蛍光指示薬間相互作用大規模解析情報を用いた疾患関連pre-miRNA結合分子の探索2022

    • Author(s)
      長澤 瞭佑、鬼塚 和光、小松 馨、宮下 映見、小澤 眞美子、齊藤 博英、永次 史
    • Organizer
      日本薬学会 第142年会
    • Related Report
      2021 Research-status Report
  • [Presentation] Unnatural base pairs with spatially isolated pseudo-nucleobases in the m+A25:D40ajor groove of DNA2021

    • Author(s)
      Hidenori Okamura, Zhuoxin Dong, Giang Hoang Trinh, Yoshiaki Masaki, Kohji Seio, Fumi Nagatsugi
    • Organizer
      Pacifichem2021 Satellite Symposium - Modified DNA and XNA for therapeutic application
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Development of the reactive OFF-ON type alkylating agents to higher ordered nucleic acids structures2021

    • Author(s)
      Fumi Nagatsugi, Madoka E. Hazemi, Norihiro Sato, Gen-ichiro Tsuji, Shunya Ishikawa, Mamiko Ozawa, Kazumitsu Onizuka
    • Organizer
      Pacifichem2021 New Challenge in Interdisciplinary and Multiscale Supramolecular Sciences
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] RNA-蛍光指示薬間相互作用大規模解析に基づくRNA結合分子探索2021

    • Author(s)
      長澤瞭佑、鬼塚和光、小松リチャード馨、宮下映見、小澤眞美子、齊藤博英、永次史
    • Organizer
      第21回東北大学多元物質科学研究所研究発表会
    • Related Report
      2021 Research-status Report
  • [Presentation] Unnatural base pairs with spatially isolated hydrogen-bonding units in the DNA major groove2021

    • Author(s)
      Hidenori Okamura, Zhuoxin Dong, Giang Hoang Trinh, Fumi Nagatsugi
    • Organizer
      ISNAC2021
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Reactivity modulation of reactive OFF-ON type alkylating reagents for higher-ordered structures of nucleic acids2021

    • Author(s)
      Yutong Chen, Kazumitsu Onizuka, Madoka E. Hazemi, Fumi Nagatsugi
    • Organizer
      ISNAC2021
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Creation of interstrand cross-linked nucleic acids and their application for miRNA inhibition2021

    • Author(s)
      Ahmed Mostafa Abdelhady, Kazumitsu Onizuka, Yu Hirano, Komatsu, Fumi Nagatsugi
    • Organizer
      ISNAC2021
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] 標的核酸に対する選択的化学反応の開発2021

    • Author(s)
      永次 史
    • Organizer
      核酸化学若手フォーラム
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] RNA標的低分子創薬を目指したRNA-蛍光指示薬間相互作用大規模解析2021

    • Author(s)
      長澤瞭佑、鬼塚和光、小松リチャード馨、宮下映見、小澤眞美子、齊藤博英、永次史
    • Organizer
      第11回CSJ化学フェスタ2021
    • Related Report
      2021 Research-status Report
  • [Presentation] Development of a photo-cyclization reaction producing phenanthridines in aqueous media2021

    • Author(s)
      飯田百香, 岡村秀紀, 金山唯, 永次史
    • Organizer
      令和3年度化学系学協会東北大会
    • Related Report
      2021 Research-status Report
  • [Presentation] RNA-蛍光指示薬間相互作用大規模解析を利用したRNA結合性低分子の探索2021

    • Author(s)
      長澤瞭佑、鬼塚和光、小松リチャード馨、宮下映見、小澤眞美子、齊藤博英、永次史
    • Organizer
      令和3年度化学系学協会東北大会
    • Related Report
      2021 Research-status Report
  • [Presentation] 副溝修飾アプタマーの探索を指向した置換基着脱型人工核酸の開発2021

    • Author(s)
      岡村秀紀, 伊藤理奈, 佐藤健太, 永次史
    • Organizer
      第15回 バイオ関連化学シンポジウム
    • Related Report
      2021 Research-status Report
  • [Presentation] RNA結合性・アルキル化反応性の大規模解析技術開発2021

    • Author(s)
      鬼塚和光、小松リチャード馨、長澤瞭佑、Yutong Chen、宮下映見、石川竣也、小嶋かんな、村瀬裕貴、小澤眞美子、齊藤博英、永次史
    • Organizer
      第15回 バイオ関連化学シンポジウム
    • Related Report
      2021 Research-status Report
  • [Presentation] Novel reactivity modulable alkylating agents for higher-order structures of nucleic acids2021

    • Author(s)
      Yutong Chen, Kazumitsu Onizuka, Madoka E. Hazemi, Fumi Nagatsugi
    • Organizer
      有機合成化学夏季国際セミナー
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Development of 2-amino-6-vinyl-7-deazapurine-deoxyriboside as an efficient cross-linking nucleoside for anti-miRNA therapy2021

    • Author(s)
      Nadia Syahla Soemawisastra, Hidenori Okamura, Fumi Nagatsugi
    • Organizer
      IS3NA-IRT Virtual Symposium 2021
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Efficient cross-linking reaction using base flip-inducing oligodeoxynucleotides2021

    • Author(s)
      Ahmed Mostafa Abdelhady, Kazumitsu Onizuka, Sayaka Yajima, Kei Ishida, Eriko Mano, Fumi Nagatsugi
    • Organizer
      IS3NA-IRT Virtual Symposium 2021
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Efficient alkene-alkene photo-cross-linking reaction on the flipping-out field in duplex DNA2021

    • Author(s)
      Ahmed Mostafa Abdelhady, Kazumitsu Onizuka, Sayaka Yajima, Kei Ishida, Eriko Mano, Fumi Nagatsugi
    • Organizer
      FIBER日本核酸化学会若手フォーラム
    • Related Report
      2021 Research-status Report
  • [Presentation] Structural optimization of alkynylated purine-pyridazine pairs for enhanced selectivity against natural nucleobases2021

    • Author(s)
      Zhuoxin Dong, Hidenori Okamura, Giang Hoang Trinh, Fumi Nagatsugi
    • Organizer
      FIBER日本核酸化学会若手フォーラム
    • Related Report
      2021 Research-status Report
  • [Presentation] Unnatural base pairs with spatially-isolated nucleobase-like modules in the major groove of DNA2021

    • Author(s)
      Hidenori Okamura, Zhuoxin Dong, Giang Hoang Trinh, Fumi Nagatsugi
    • Organizer
      FIBER日本核酸化学会若手フォーラム
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] RNA 結合性低分子探索に向けたRNA-蛍光指示薬間相互作用大規模解析2021

    • Author(s)
      長澤瞭佑、鬼塚和光、小松リチャード馨、宮下映見、小澤眞美子、齊藤博英、永次史
    • Organizer
      生体機能関連化学部会若手の会 第32回サマースクール
    • Related Report
      2021 Research-status Report
  • [Presentation] RNA-小分子間化学シグナル大規模解析技術の展開2021

    • Author(s)
      鬼塚和光、小松リチャード馨、齊藤博英、永次史
    • Organizer
      「化学コミュニケーションのフロンティア」第8回公開シンポジウム
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] RNAアルキル化反応の大規模解析技術開発2021

    • Author(s)
      鬼塚和光、小松リチャード馨、石川竣也、Yutong Chen、小嶋かんな、村瀬裕貴、長澤瞭佑、小澤眞美子、宮下映見、齊藤博英、永次史
    • Organizer
      日本ケミカルバイオロジー学会 第15回年会
    • Related Report
      2021 Research-status Report
  • [Presentation] 副溝修飾アプタマーの探索を指向した置換基着脱型ヌクレオシドの開発2021

    • Author(s)
      岡村秀紀, 伊藤理奈, 佐藤健太, 永次史
    • Organizer
      日本ケミカルバイオロジー学会 第15回年会
    • Related Report
      2021 Research-status Report
  • [Presentation] RNA 標的創薬を志向したRNA-蛍光指示薬間相互作用大規模解析2021

    • Author(s)
      長澤瞭佑、鬼塚和光、小松リチャード馨、宮下映見、小澤眞美子、齊藤博英、永次史
    • Organizer
      第32回万有仙台シンポジウム
    • Related Report
      2021 Research-status Report
  • [Book] Handbook of Chemical Biology of Nucleic Acids2022

    • Author(s)
      Fumi Nagatsugi
    • Total Pages
      1990
    • Publisher
      Springer Singapore
    • Related Report
      2022 Annual Research Report
  • [Book] 進化を続ける核酸化学2021

    • Author(s)
      日本化学会
    • Total Pages
      228
    • Publisher
      化学同人
    • ISBN
      9784759814019
    • Related Report
      2021 Research-status Report
  • [Book] Middle Nolecular Strategy2021

    • Author(s)
      Fumi Nagatsugi
    • Total Pages
      357
    • Publisher
      Springer
    • ISBN
      9789811624575
    • Related Report
      2021 Research-status Report
  • [Remarks]

    • URL

      http://www2.tagen.tohoku.ac.jp/lab/nagatsugi/html/

    • Related Report
      2021 Research-status Report
  • [Patent(Industrial Property Rights)] 核酸内グアニン塩基結合性蛍光色素2022

    • Inventor(s)
      鬼塚 和光,長澤 瞭佑,岩田 遼平,村瀬 裕貴,永次 史
    • Industrial Property Rights Holder
      鬼塚 和光,長澤 瞭佑,岩田 遼平,村瀬 裕貴,永次 史
    • Industrial Property Rights Type
      特許
    • Filing Date
      2022
    • Related Report
      2022 Annual Research Report
  • [Patent(Industrial Property Rights)] RNAの高次構造解析方法2021

    • Inventor(s)
      小松 リチャード 馨, 宮下 映見, 鬼塚 和光, 永次 史
    • Industrial Property Rights Holder
      小松 リチャード 馨, 宮下 映見, 鬼塚 和光, 永次 史
    • Industrial Property Rights Type
      特許
    • Filing Date
      2021
    • Related Report
      2021 Research-status Report

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Published: 2021-07-13   Modified: 2024-01-30  

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