Exploring anti-aging factors secreted by bacteria that extend the lifespan of insects
| Project/Area Number |
21K19239
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
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| Research Institution | Hosei University |
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Principal Investigator |
Oshima Kenro 法政大学, 生命科学部, 教授 (00401183)
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| Project Period (FY) |
2021-07-09 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2022: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2021: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | ファイトプラズマ / 老化 / 分泌タンパク質 |
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| Outline of Research at the Start |
ファイトプラズマは、植物や昆虫の細胞内に寄生する細菌である。植物に対しては病気を引き起こし、世界中で多くの作物に被害を与えている。一方、昆虫がファイトプラズマに感染しても病状は全く現れず、逆に寿命が延びたり、高齢になっても活発に産卵するなどの「アンチエイジング効果」が現れる。本研究では、ファイトプラズマが分泌するタンパク質の中から老化を抑えるアンチエイジング因子を探索する。
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| Outline of Final Research Achievements |
Phytoplasma is a pathogenic bacterium that parasitizes within plant cells. Phytoplasmas intracellularly parasitize not only plants but also insects, and are transmitted from plant to plant via insect vectors. Insect vectors infected with phytoplasma have a longer lifespan and maintain the number of eggs laid even in old age. Although the mechanism involved in the anti-aging effect of phytoplasma has been of interest, the whole picture has been unclear. In this study, we aimed to elucidate the mechanism of host manipulation involved in this phenomenon, and cloned a total of 7 new phytoplasma secreting proteins and identified host proteins that interact with the secretory proteins.
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| Academic Significance and Societal Importance of the Research Achievements |
一般に細胞の老化には酸化や糖化が関わることが知られているが、ファイトプラズマの分泌タンパク質にはこのような酵素活性に関わるモチーフやドメインが存在しない。そのため、これまでの知見とは全く異なるメカニズムで老化を抑えている可能性を秘めており、新たな視点からアンチエイジングの研究分野に切り込むことが期待される。
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Report
(3 results)
Research Products
(28 results)
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[Journal Article] Revision of the ‘Candidatus Phytoplasma’ species description guidelines2022
Author(s)
Bertaccini Assunta、Arocha-Rosete Yaima、Contaldo Nicoletta、Duduk Bojan、Fiore Nicola、Montano Helena Guglielmi、Kube Michael、Kuo Chih-Horng、Martini Marta、Oshima Kenro、Quaglino Fabio、Schneider Bernd、Wei Wei、Zamorano Alan
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Journal Title
International Journal of Systematic and Evolutionary Microbiology
Volume: 72
Issue: 4
Pages: 005353-005353
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Book] 植物医科学2022
Author(s)
濱本宏, 鍵和田聡, 前島健作, 難波成任, 大島研郎, 山次康幸
Total Pages
544
Publisher
養賢堂
ISBN
4842505842
Related Report
