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Evaluation of error-correction learning theories for social learning in an insect

Research Project

Project/Area Number 21K19245
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 44:Biology at cellular to organismal levels, and related fields
Research InstitutionHokkaido University

Principal Investigator

Mizunami Makoto  北海道大学, 理学研究院, 教授 (30174030)

Project Period (FY) 2021-07-09 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2022: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2021: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Keywords社会学習 / 予測誤差学習 / 2次条件付け / 昆虫 / オクトパミン / コオロギ / 報酬
Outline of Research at the Start

他個体の行動の観察し知識を獲得する「社会学習」は、ヒトや動物の生存に大きく寄与する。しかしそのニューロン機構はほとんど分かっていない。最近、ヒトの社会学習が、通常の連合学習と同様に、「報酬予測誤差」に基づいておこるという仮説が提案され、その実験的検証が切望されている。
研究代表者は、コオロギの連合学習が、哺乳類の連合学習と同様、動物が予測する報酬や罰と実際に受け取る報酬や罰の差、すなわち「予測誤差」に基づいて起こることを発見した。またコオロギには社会学習の高い能力があることを発見した。
本研究では、コオロギを研究材料として用い、その社会学習が予測誤差仮説で説明できるかの検証に挑戦する。

Outline of Final Research Achievements

Social learning is found in many animals, but its mechanisms are not understood. We previously showed that a cricket that was trained to observe a conspecific staying at a drinking apparatus exhibited an increased preference for the odor of that drinking apparatus. Here we investigated a hypothesis that this learning is achieved by second-order conditioning (SOC), i.e., by associating conspecifics at a drinking bottle with water reward during group drinking in the rearing stage and then associating an odor with a conspecific in training. Injection of an octopamine receptor antagonist before training or testing impaired the learning or response to the learned odor, as we reported for SOC, thereby supporting the hypothesis. Notably, the SOC hypothesis predicts that octopamine neurons that respond to water in the group-rearing stage also respond to a conspecific in training, without the learner itself drinking water, and such mirror-like activities mediate social learning.

Academic Significance and Societal Importance of the Research Achievements

多くの動物は他個体の行動から学ぶ社会学習を示すが、その仕組みはよく分かっていない。本研究での薬理的な解析の結果、フタホシコオロギの社会学習が「2次条件付け」によって起こることが示唆された。私達が提案する2次条件付けの神経回路モデルからは、オクトパミンニューロンは自身が水を飲む時に発火するが、他個体が水を飲むのを見た時にも発火すること、その様な「ミラー様の神経活動」が社会学習をもたらすことが予測される。昆虫のニューロンが哺乳類と同様に「ミラー様神経活動」を示し社会学習を実現するという本研究での提案は、大きな注目を集めると期待される。

Report

(3 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • Research Products

    (19 results)

All 2023 2022 2021 Other

All Int'l Joint Research (2 results) Journal Article (6 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 6 results,  Open Access: 5 results) Presentation (9 results) (of which Int'l Joint Research: 3 results) Remarks (2 results)

  • [Int'l Joint Research] Harvard University(米国)

    • Related Report
      2022 Annual Research Report
  • [Int'l Joint Research] Universidad Publica de Navarra(スペイン)

    • Related Report
      2022 Annual Research Report
  • [Journal Article] oskar acts with the transcription factor Creb to regulate long-term memory in crickets.2023

    • Author(s)
      Kulkarni, A., Ewen-Campen, B., Terao, K., Matsumoto, Y., Li, Y., Watanabe, T., Kao, J. A., Parhad, S. S., Ylla, G., Mizunami, M.. Extavour, C. G.
    • Journal Title

      PNAS

      Volume: -

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Octopamine neurons mediate reward signals in social learning in an insect2023

    • Author(s)
      Yuma Segi, Kohei Hashimoto, Mamkoto Mizunami
    • Journal Title

      iScience

      Volume: -

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Spontaneous recovery from overexpectation in an insect2022

    • Author(s)
      Terao Kanta、Matsumoto Yukihisa、Alvarez Beatriz、Mizunami Makoto
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 9827-9827

    • DOI

      10.1038/s41598-022-13800-2

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Conditioned taste aversion in the cricket Gryllus bimaculatus2022

    • Author(s)
      Lyu Hui、Mizunami Makoto
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 9751-9751

    • DOI

      10.1038/s41598-022-13500-x

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Silencing the odorant receptor co-receptor impairs olfactory reception in a sensillum-specific manner in the cockroach2022

    • Author(s)
      Tateishi Kosuke、Watanabe Takayuki、Nishino Hiroshi、Mizunami Makoto、Watanabe Hidehiro
    • Journal Title

      iScience

      Volume: 25 Issue: 5 Pages: 104272-104272

    • DOI

      10.1016/j.isci.2022.104272

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] What Is Learned in Pavlovian Conditioning in Crickets? Revisiting the S-S and S-R Learning Theories2021

    • Author(s)
      Mizunami Makoto
    • Journal Title

      Frontiers in Behavioral Neuroscience

      Volume: 15 Pages: 661225-661225

    • DOI

      10.3389/fnbeh.2021.661225

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Transcriptomic and phylogenetic analyses for the periplanone receptor gene family in the antennae of Blattidae cockroaches.2023

    • Author(s)
      Takayuki Watanabe, Hiroshi Nishino, Kosuke Tateishi, Hidehiro Watanabe, Makoto Mizunami
    • Organizer
      International Conference for Blattodea Research
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Functional elucidation of two sex pheromones in the American cockroach; from receptions to behaviors2023

    • Author(s)
      Kosuke Tateishi, Takayuki Watanabe, Mana Domae, Hiroshi Nishino, Makoto Mizunami, Hidehiro Watanabe
    • Organizer
      International Conference for Blattodea Research
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Transcriptome analyses of chemosensory receptor genes in the antennae of cockroaches and a cricket.2022

    • Author(s)
      Takayuki Watanabe, Makoto Mizunami, Hiroshi Nishino, Hidehiro Watanabe, Kosuke Tateishi
    • Organizer
      Annual meeting of the Japanese Society for Comparative Physiology and Biochemistry
    • Related Report
      2022 Annual Research Report
  • [Presentation] Two distinct sex pheromone processing pathways in the American cockroach; from receptions to behaviors.2022

    • Author(s)
      Kosuke Tateishi, Takayuki Watanabe, Mana Domae, Hiroshi Nishino, Makoto Mizunami, Hidehiro Watanabe
    • Organizer
      Annual meeting of the Japanese Society for Comparative Physiology and Biochemistry
    • Related Report
      2022 Annual Research Report
  • [Presentation] Roles of octopamine and dopamine neurons in the formation of parallel appetitive and aversive memories and their control over conditioned response in Pavlovian conditioning in the cricket Gryllus bimaculatus2022

    • Author(s)
      Sadniman Rahman, Makoto Mizunami
    • Organizer
      Annual meeting of the Japanese Society for Comparative Physiology and Biochemistry
    • Related Report
      2022 Annual Research Report
  • [Presentation] コオロギ(Gryllus bimaculatus)における嫌悪性社会学習メカニズムの解明2022

    • Author(s)
      橋本光平, 水波誠
    • Organizer
      日本動物学会大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] ワモンゴキブリの2種の性フェロモンの受容機構と行動的役割の違い2022

    • Author(s)
      立石康介,渡邊崇之,西野浩史,水波誠,渡邉英博
    • Organizer
      日本動物学会大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Functional and developmental analysesofthe sex pheromone receptionsystem in the American cockroach during the nymphal-adult transition2022

    • Author(s)
      Kosuke Tateishi, Takayuki Watanabe, Hiroshi Nishino, Makoto Mizunami, Hiroyuki Ai, Hidehiro Watanabe
    • Organizer
      International Congress of Neuroethology
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Pharmacological analysis of social learning in the cricket Gryllus bimaculatus.2021

    • Author(s)
      Yuma Segi, Makoto Mizunami
    • Organizer
      日本比較生理生化学会
    • Related Report
      2021 Research-status Report
  • [Remarks] 水波研ホームページ

    • URL

      https://www.sci.hokudai.ac.jp/~mizunami/MICROB~2/

    • Related Report
      2022 Annual Research Report
  • [Remarks] 水波研究室ホームページ

    • URL

      https://www.sci.hokudai.ac.jp/~mizunami/MICROB~2/

    • Related Report
      2021 Research-status Report

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Published: 2021-07-13   Modified: 2024-01-30  

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