Development of new preventive or therapeutic strategies for hematopoietic neoplasms based on metabolic analysis.
| Project/Area Number |
21K19502
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
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| Research Institution | Kanazawa University |
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Principal Investigator |
Hirao Atsushi 金沢大学, がん進展制御研究所, 教授 (90343350)
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| Co-Investigator(Kenkyū-buntansha) |
加藤 将夫 金沢大学, 薬学系, 教授 (30251440)
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| Project Period (FY) |
2021-07-09 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2022: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2021: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 代謝 / 代謝物 |
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| Outline of Research at the Start |
本研究では、造血器腫瘍患者および疾患モデルを研究対象とし、メタボロミクスによる代謝物の網羅的探索法の確立、代謝物の機能解析法の確立を進め、造血器腫瘍の治療および予防に資する代謝物探索システムの構築を目指す。本研究では、観測対象を特定しないメタボロミクス法を用いて、幅広く有用な代謝物を探索し、代謝物による造血制御という新たな研究領域への展開を目指す。
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| Outline of Final Research Achievements |
In this study, we aimed to establish a metabolite discovery system that contributes to the treatment and prevention of hematopoietic tumors by (1) conducting a comprehensive search for metabolites by metabolomics and (2) analyzing the functions of metabolites in disease models. As a result of our analysis, we observed that myeloproliferative disease was accelerated by a long-term high-fat diet. Metabolomic analysis revealed that many metabolites are altered by a high-fat diet, and that a metabolite had functions that inhibited the pathophysiology of the disease. Further development based on the findings of this study may lead to the identification of disease biomarkers and the development of therapeutic agents in the future.
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| Academic Significance and Societal Importance of the Research Achievements |
昨今、様々な病態解明を目指して、ゲノミクス、プロテオミクス、エピジェネティクス解析など生体サンプルの網羅的解析が進んでいる。今回、我々は最新の質量分析法によるデータ収集、インフォマティクス解析を実施し、重要な代謝物を同定するシステムを構築することができた。本研究は，代謝物という観点から造血器疾患の病態の解明に挑む新しいアプローチとして、多くの疾患研究の次世代型プロトタイプになり得る。
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Report
(3 results)
Research Products
(14 results)
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[Journal Article] RHEB is a potential therapeutic target in T cell acute lymphoblastic leukemia2022
Author(s)
Pham Loc Thi、Peng Hui、Ueno Masaya、Kohno Susumu、Kasada Atuso、Hosomichi Kazuyoshi、Sato Takehiro、Kurayoshi Kenta、Kobayashi Masahiko、Tadokoro Yuko、Kasahara Atsuko、Shoulkamy Mahmoud I.、Xiao Bo、Worley Paul F.、Takahashi Chiaki、Tajima Atsushi、Hirao Atsushi
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Journal Title
Biochemical and Biophysical Research Communications
Volume: 621
Pages: 74-79
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Intracellular metabolic adaptation of intraepithelial CD4+CD8αα+ T lymphocytes2022
Author(s)
Harada Y, Sujino T, Miyamoto K, Nomura E, Yoshimatsu Y, Tanemoto S, Umeda S, Ono K, Mikami Y, Nakamoto N, Takabayashi K, Hosoe N, Ogata H, Ikenoue T, Hirao A, Kubota Y, Kanai T.
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Journal Title
iScience
Volume: 25
Issue: 4
Pages: 104021-104021
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] CDK8 maintains stemness and tumorigenicity of glioma stem cells by regulating the c-MYC pathway2021
Author(s)
Fukasawa K, Kadota T, Horie T, Tokumura K, Terada R, Kitaguchi Y, Park G, Ochiai S, Iwahashi S, Okayama Y, Hiraiwa M, Yamada T, Iezaki T, Kaneda K, Yamamoto M, Kitao T, Shirahase H, Hazawa M, Wong RW, Todo T, Hirao A, Hinoi E.
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Journal Title
Oncogene
Volume: ー
Issue: 15
Pages: 2803-2815
DOI
Related Report
Peer Reviewed / Open Access
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