Development of a novel transplantation therapy using a short bowel syndrome model
Project/Area Number |
21K19540
|
Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
|
Allocation Type | Multi-year Fund |
Review Section |
Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
|
Research Institution | Keio University |
Principal Investigator |
SUGIMOTO Shinya 慶應義塾大学, 医学部(信濃町), 助教 (20626387)
|
Project Period (FY) |
2021-07-09 – 2023-03-31
|
Project Status |
Completed (Fiscal Year 2022)
|
Budget Amount *help |
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2022: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2021: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
|
Keywords | 短腸症候群 / 小腸移植 / 幹細胞 / 腸管不全 / GLP-2アナログ |
Outline of Research at the Start |
重症の短腸症候群に対する唯一の根治療法となりうる小腸移植は,小腸の他の臓器に比して強い拒絶反応のため移植後の管理に難渋しており,実施例はごく少数に限られている.本研究では,自己の小腸由来細胞を移植細胞として用いることにより,生涯の免疫抑制を要さない新規移植療法の開発を目指し,短腸症候群モデル動物における知見の創出とヒトへの応用へ向けた研究基盤の構築を目的とする.
|
Outline of Final Research Achievements |
Modification of the length and site of the resected intestine and improvement of perioperative management of the short bowel syndrome rat model, which has been the subject of cell transplantation, led to an increase in the efficiency of transplant tissue analysis. The conditions of pre-treatment of the recipient tissue at the small animal level were modified and the results were applied to large animals. The extraction of issues ex vivo and in vivo as well as at the small animal level has led to improved epithelial removal efficiency at the large animal level, which has previously been difficult to achieve. This research has established a basic foundation for research aimed at human application.
|
Academic Significance and Societal Importance of the Research Achievements |
これまでにない新しいコンセプトでの腸管への小腸由来細胞移植の研究開発を行う上で、短腸症候群モデル動物における知見の創出は重要である。また、短腸症候群に対する免疫抑制を要さない新規移植療法の開発を目指す上で、ヒトへの応用を見据えた挑戦的な研究展開に欠かせない大動物実験の研究基盤が構築されたことは、今後の小腸由来細胞移植の大動物コンセプト確認や安全性の検証のために重要な意義をもつ。今後の研究への活用が期待される。
|
Report
(3 results)
Research Products
(56 results)
-
-
-
-
-
-
-
-
[Journal Article] Identification of Quiescent LGR5+ Stem Cells in the Human Colon2022
Author(s)
Ishikawa K, Sugimoto S, Oda M, Fujii M, Toshimitsu K, Sawada K, Shimokawa M, Saito M, Kawasaki K, Ishii R, Taniguchi K, Sato T.
-
Journal Title
Gastroenterology.
Volume: 163
Issue: 5
Pages: 1391-1406
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
[Journal Article] 潰瘍性大腸炎に伴うdysplasiaに対する内視鏡治療はどのように考えるのか?2022
Author(s)
高林 馨, 杉本 真也, 吉松 裕介, 清原 裕貴, 三上 洋平, 筋野 智久, 河口 貴昭, 加藤 元彦, 細江 直樹, 岩男 泰, 矢作 直久, 金井 隆典, 緒方 晴彦
-
Journal Title
消化器・肝臓内科
Volume: 12
Pages: 158-164
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Dose escalation of oral 5-aminosalicylic acid for ulcerative colitis with Mayo endoscopic subscore of one improves long-term prognosis: a one-year multicentre, open-label, randomized controlled trial2023
Author(s)
Yasuhiro Aoki, Tomohiro Fukuda, Hiroki Kiyohara, Ayumi Yokoyama, Atsushi Nakazawa, Yusuke Yoshimatsu, Shinya Sugimoto, Kosaku Nanki, Yohei Mikami, Kayoko Fukuhara, Shinta Mizuno, et al.
Organizer
18th Congress of European Crohn’s and Colitis Organization (ECCO 2023)
Related Report
Int'l Joint Research
-
-
-
-
-
[Presentation] Investigation of endoscopic chronological evolution of ulcerative colitis-associated neoplasia2022
Author(s)
Yusuke Wakisaka, Shinya Sugimoto, Yasushi Iwao, Kaoru Takabayashi, Yusuke Yoshimatsu, Hiroki Kiyohara, Takaaki Kawaguchi, Tomohisa Sujino, Naoki Hosoe, Haruhiko Ogata, Yohei Mikami, Takanori Kanai
Organizer
The 10th Annual Meeting of the Asian Organization for Crohn's & Colitis
Related Report
Int'l Joint Research
-
-
[Presentation] Successful Combination Therapy with Infliximab and Cyclosporine A for Refractory Myelodysplastic Syndrome associated Small Intestinal Ulcers: A case report2022
Author(s)
Shogo Sunaga, Hiroki Kiyohara, Kurato Miyazaki, Ryosuke Kasuga, Kaoru Takabayashi, Naoki Hosoe, Takaaki Kawaguchi, Yohei Mikami, Kosaku Nanki, Yusuke Yoshimatsu, Shinya Sugimoto, Tomohisa Sujino, Yasushi Iwao, Haruhiko Ogata, Takanori Kanai
Organizer
The 10th Annual Meeting of the Asian Organization for Crohn's & Colitis
Related Report
Int'l Joint Research
-
[Presentation] Effectiveness and Durability of Ustekinumab Therapy With or Without Immunomodulators for Ulcerative Colitis Patients2022
Author(s)
Yasuhiro Aoki, Tomohisa Sujino, Takaaki Kawaguchi, Shinya Sugimoto, Fumie Shimada, Yusuke Yoshimatsu, Hiroki Kiyohara, Kosaku Nanki, Yohei Mikami, Kaoru Takabayashi, Naoki Hosoe, Haruhiko Ogata, Yasushi Iwao, Takanori Kanai
Organizer
The 10th Annual Meeting of the Asian Organization for Crohn's & Colitis
Related Report
Int'l Joint Research
-
-
[Presentation] Serum LRG as a novel biomarker of disease and endoscopic activity in patients with Crohn’s disease2022
Author(s)
Yoshiaki Takada, Hiroki Kiyohara, Yohei Mikami, Fumie Shimada, Yuta Matsubara, Ryoya Sakakibara, Yasuhiro Aoki, Masataka Ichikawa, Yusuke Wakisaka, Yuya Hagihara, Shun Tanemoto, Satoko Umeda, Yusuke Yoshimatsu, Keiko Ono, Emi Irie, Shinya Sugimoto, Kosaku Nanki, et al.
Organizer
The 10th Annual Meeting of the Asian Organization for Crohn's & Colitis
Related Report
Int'l Joint Research
-
-
[Presentation] Prognosis in the treatment of the 2nd line anti-TNF inhibitor in patients with ulcerative colitis2022
Author(s)
Hiroki Kiyohara, Takaaki Kawaguchi, Yohei Mikami, Yusuke Yoshimatsu, Shinya Sugimoto, Tomohisa Sujino, Kaoru Takabayashi, Naoki Hosoe, Yasushi Iwao, Haruhiko Ogata, Takanori Kanai
Organizer
The 10th Annual Meeting of the Asian Organization for Crohn's & Colitis
Related Report
Int'l Joint Research
-
-
-
[Presentation] 内視鏡Mayoスコア1の臨床的寛解潰瘍性大腸炎患者に対する経口5-ASA製剤の増量は臨床的再燃を抑制する2022
Author(s)
福田知広, 青木康浩, 清原裕貴, 横山 歩, 吉松裕介, 杉本真也, 南木康作, 三上洋平, 福原佳代子, 水野慎大, 筋野智久, 牟田口 真, 高林 馨, 諸星雄一, 中澤 敦, 細田泰雄, 緒方晴彦, 岩男 泰, 長沼 誠, 金井隆典
Organizer
第13回日本炎症性腸疾患学会学術集会
Related Report
-
-
[Presentation] 自然整復した成人の特発性小腸重積症の一例2022
Author(s)
韓可, 吉松裕介, 杉本真也, 清原裕貴, 三上洋平, 筋野智久, 河口貴昭, 高林馨, 細江直樹, 緒方晴彦, 金井隆典
Organizer
日本消化器病学会 関東支部第372回例会
Related Report
-
-
-
-
-
-
-
-
[Presentation] 微小変化型ネフローゼ症候群に合併した重症IBD-unclassifiedの一例2021
Author(s)
海江田 祐太, 清原 裕貴, 宮崎 蔵人, 三上 洋平, 河口 貴昭, 南木 康作, 筋野 智久, 高林 馨, 杉本 真也, 細江 直樹, 緒方 晴彦, 岩男 泰, 金井 隆典
Organizer
日本消化器病学会関東支部第366回例会
Related Report
-
[Presentation] クローン病の疾患活動性モニタリング法としての,血清LRG値の有用性の検討2021
Author(s)
高田祐明, 三上洋平, 青木康浩, 市川将隆, 脇坂悠介, 萩原裕也, 種本俊, 梅田智子, 吉松裕介, 杉本真也, 清原裕貴, 南木康作, 筋野智久, 河口貴昭, 高林馨, 細江直樹, 緒方晴彦, 金井隆典
Organizer
第39回大腸検査学会総会
Related Report
-
-
[Presentation] Incidence and risk factors of venous thromboembolism in inpatients with inflammatory bowel disease2021
Author(s)
Yasuhiro Aoki, Hiroki Kiyohara, Kosaku Nanki, Yohei Mikami, Takaaki Kawaguchi, Tomohisa Sujino, Shinya Sugimoto, Kaoru Takabayashi, Kayoko Fukuhara, Naoki Hosoe, Haruhiko Ogata, Yasushi Iwao, Takanori Kanai
Organizer
The 9th Annual Meeting of the Asian Organization for Crohn's and Colitis (AOCC 2021)
Related Report
Int'l Joint Research
-
[Presentation] Continuous intravenous cyclosporine therapy improves short term prognosis in patients with severe ulcerative colitis refractory to multiple molecular target therapies2021
Author(s)
Yuta Matsubara, Hiroki Kiyohara, Yasuhiro Aoki, Tomohiro Fukuda, Kosaku Nanki, Yohei Mikami, Takaaki Kawaguchi, Tomohisa Sujino, Shinya Sugimoto, Kaoru Takabayashi, Kayoko Fukuhara, Naoki Hosoe, Haruhiko Ogata, Yasushi Iwao, Makoto Naganuma, Takanori Kanai
Organizer
The 9th Annual Meeting of the Asian Organization for Crohn's and Colitis (AOCC 2021)
Related Report
Int'l Joint Research
-
[Presentation] 血管増生を背景とした境界のある発赤は潰瘍性大腸炎関連平坦型dysplasia発見の有用なマーカーである2021
Author(s)
池端 昭慶, 下田 将之, 岡林 剛史, 茂田 浩平, 清島 亮, 松井 信平, 杉本 真也, 矢作 直久, 金井 隆典, 北川 雄光, 金井 弥栄, 岩男 泰
Organizer
第76回日本大腸肛門病学会学術集会
Related Report
-
-
[Presentation] 炎症性腸疾患患者における静脈血栓塞栓症の臨床的検討2021
Author(s)
青木 康浩, 清原 裕貴, 南木 康作, 三上 洋平, 河口 貴昭, 筋野 智久, 杉本 真也, 高林 馨, 福原 佳代子, 細江 直樹, 緒方 晴彦, 岩男 泰, 金井 隆典
Organizer
第12回日本炎症性腸疾患学会学術集会
Related Report