• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Elucidation of the mechanisms of healthy kidney formation via nutrient sensing signals during the fetal period

Research Project

Project/Area Number 21K19721
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
Research InstitutionKumamoto University

Principal Investigator

Baba Masaya  熊本大学, 病院, 助教 (10347304)

Co-Investigator(Kenkyū-buntansha) 有馬 勇一郎  熊本大学, 国際先端医学研究機構, 特任准教授 (60706414)
Project Period (FY) 2021-07-09 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2022: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2021: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywords腎発生 / 胎生期 / 栄養状態 / 栄養感知機構 / Flcn / ネフロン前駆細胞
Outline of Research at the Start

腎臓の機能単位であるネフロンは再生せず加齢に伴い減少する。生涯にわたり腎機能を良好に維持する為には、充分数のネフロンを持った健全な腎臓を形成する事が重要である。ネフロン前駆細胞は胎生期に複製と分化のバランスを適正に保ちつつネフロンへと分化し、充分なネフロンが形成される頃に全て分化して消失する。胎生期の低栄養がネフロンの減少と高い相関関係にある事は既知だが、ネフロン前駆細胞の複製・分化のバランスと栄養状態との関係は未解明である。本研究は、独自の研究背景と予備データを足掛かりに母体からの栄養が細胞内栄養感知機構を介し、ネフロン前駆細胞の複製と分化のバランスを制御する分子機構を解明する。

Outline of Final Research Achievements

This study aims to elucidate the effects of maternal nutrition on fetal kidney development and contribute to promoting healthy nephrogenesis. To this end, we conducted research using nephron progenitor cell-specific nutrient-sensing mechanism-deficient mice (FlcnKO mice) and a low birth weight model induced by maternal nutritional restriction during pregnancy. In low birth weight P0 mice, a reduction in the number of glomeruli was observed, supporting findings reported in humans. In FlcnKO P0 mice, a decrease in nephron progenitor cells, expansion of Bowman's capsule, and abnormalities in the loops of Henle were noted. Additionally, in the kidneys of FlcnKO mice, the nutrient-responsive transcription factor Tfe3 was localized in the nucleus, suggesting that abnormal activation of Tfe3 might contribute to kidney developmental abnormalities.

Academic Significance and Societal Importance of the Research Achievements

腎臓の機能単位であるネフロンは再生することがなく生理的な加齢と共に減少していく。その為、生涯にわたり腎臓の機能を良好に維持する為には、充分な数のネフロンを持った健全な腎臓を胎生期に形成する事が不可欠である。大規模な疫学調査により、胎生期における母体の低栄養が子供のネフロン数の減少と高い相関関係にあることが明らかにされており、胎生期の栄養と腎臓の発生の間には深い関係があることが示唆されてきた。母体の栄養制限で新生児のネフロン数が減少し、胎児の栄養感知機構のノックアウトがネフロン前駆細胞の減少を引き起こす事を見出した本研究は、母体からの栄養が胎児の腎発生に与える影響を明らかにする足がかりとなる。

Report

(4 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • Research Products

    (33 results)

All 2024 2023 2022 2021 Other

All Int'l Joint Research (4 results) Journal Article (11 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 11 results,  Open Access: 10 results) Presentation (17 results) (of which Int'l Joint Research: 2 results) Remarks (1 results)

  • [Int'l Joint Research] National Institutes of Health(米国)

    • Related Report
      2023 Annual Research Report
  • [Int'l Joint Research] National Institutes of Health(米国)

    • Related Report
      2022 Research-status Report
  • [Int'l Joint Research] National Cancer Institute / NIH(米国)

    • Related Report
      2021 Research-status Report
  • [Int'l Joint Research] national university of singapore(シンガポール)

    • Related Report
      2021 Research-status Report
  • [Journal Article] T1a Renal Cell Carcinoma With Metastasis: Japanese Society of Renal Cancer Retrospective Multi-institute Results2023

    • Author(s)
      KATO TAIGO、WANG CONG、MASUMORI NAOYA、YAMASAKI TOSHINARI、MATSUMOTO HIROAKI、BABA MASAYA、ITO KEIICHI、KIMURA TAKAHIRO、KITAMURA HIROSHI、TAKAHASHI MASAYUKI、HONGO FUMIYA、HASINE KATSUYOSHI、ETO MASATOSHI、IKEDA JUN-ICHIRO、NONOMURA NORIO、SHINOHARA NOBUO
    • Journal Title

      Anticancer Research

      Volume: 43 Issue: 9 Pages: 4061-4065

    • DOI

      10.21873/anticanres.16595

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A stepwise and digital pattern of RSK phosphorylation determines the outcome of thymic selection2023

    • Author(s)
      Funasaki Shintaro、Hatano Atsushi、Nakatsumi Hirokazu、Koga Daisuke、Sugahara Osamu、Yumimoto Kanae、Baba Masaya、Matsumoto Masaki、Nakayama Keiichi I.
    • Journal Title

      iScience

      Volume: 26 Issue: 9 Pages: 107552-107552

    • DOI

      10.1016/j.isci.2023.107552

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ANGPTL2‐mediated epigenetic repression of MHC‐I in tumor cells accelerates tumor immune evasion2023

    • Author(s)
      Kadomatsu Tsuyoshi、Hara Chiaki、Kurahashi Ryoma、Horiguchi Haruki、Morinaga Jun、Miyata Keishi、Kurano Sohtaro、Kanemaru Hisashi、Fukushima Satoshi、Araki Kimi、Baba Masaya、Linehan W. Marston、Kamba Tomomi、Oike Yuichi
    • Journal Title

      Molecular Oncology

      Volume: 17 Issue: 12 Pages: 2637-2658

    • DOI

      10.1002/1878-0261.13490

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Comparative analyses define differences between BHD-associated renal tumour and sporadic chromophobe renal cell carcinoma2023

    • Author(s)
      Jikuya R, Johnson TA, Maejima K, An J, Ju YS, Lee H, Ha K, Song W, Kim Y, Okawa Y, Sasagawa S, Kanazashi Y, Fujita M, Imoto S, Furuya M, Kato I, Fujii S, Hamanoue H, Tamura T, Baba M, Suda T, Kodama T, Makiyama K, Yao M, Schmidt LS, Linehan WM, Nakagawa H, Hasumi H.
    • Journal Title

      EBioMedicine

      Volume: 92 Pages: 104596-104596

    • DOI

      10.1016/j.ebiom.2023.104596

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] TFEB-translocated and -amplified renal cell carcinoma with VEGFA co-amplification: A case of long-term control by multimodal therapy including a vascular endothelial growth factor-receptor inhibitor2023

    • Author(s)
      Takamori H, Maeshima AM, Kato I, Baba M, Nakamura E, Matsui Y.
    • Journal Title

      IJU Case Rep.

      Volume: 10.1002/iju5.12575. Issue: 3 Pages: 161-164

    • DOI

      10.1002/iju5.12575

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] MiT/TFE Family Renal Cell Carcinoma.2023

    • Author(s)
      Tang J, Baba M.
    • Journal Title

      Genes

      Volume: 14 Issue: 1 Pages: 151-151

    • DOI

      10.3390/genes14010151

    • Related Report
      2023 Annual Research Report 2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] TFE3-immunopositive papillary renal cell carcinoma: A clinicopathological, immunohistochemical, and genetic study2023

    • Author(s)
      Takamatsu D, Kohashi K, Kiyozawa D, Kinoshita F, Ieiri K, Baba M, Eto M, Oda Y.
    • Journal Title

      Pathol Res Pract.

      Volume: 242 Pages: 154313-154313

    • DOI

      10.1016/j.prp.2023.154313

    • Related Report
      2023 Annual Research Report 2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Single-cell transcriptomes underscore genetically distinct tumor characteristics and microenvironment for hereditary kidney cancers2022

    • Author(s)
      Jikuya R, Murakami K, Nishiyama A, Kato I, Furuya M, Nakabayashi J, Ramilowski JA, Hamanoue H, Maejima K, Fujita M, Mitome T, Ohtake S, Noguchi G, Kawaura S, Odaka H, Kawahara T, Komeya M, Shinoki R, Ueno D, Ito H, Ito Y, Muraoka K, Hayashi N, Kondo K, et.al.
    • Journal Title

      iScience

      Volume: 25(6) Issue: 6 Pages: 104463-104463

    • DOI

      10.1016/j.isci.2022.104463

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Targeting chemoresistance in Xp11.2 translocation renal cell carcinoma using a novel polyamide?chlorambucil conjugate2022

    • Author(s)
      Funasaki Shintaro、Mehanna Sally、Ma Wenjuan、Nishizawa Hidekazu、Kamikubo Yasuhiko、Sugiyama Hiroshi、Ikeda Shuji、Motoshima Takanobu、Hasumi Hisashi、Linehan W. Marston、Schmidt Laura S.、Ricketts Chris、Suda Toshio、Oike Yuichi、Kamba Tomomi、Baba Masaya
    • Journal Title

      Cancer Science

      Volume: n/a Issue: 7 Pages: 2352-2367

    • DOI

      10.1111/cas.15364

    • Related Report
      2022 Research-status Report 2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Seventh BHD international symposium: recent scientific and clinical advancement.2022

    • Author(s)
      Woodford MR, Andreou A, Baba M, van de Beek I, Di Malta C, Glykofridis I, Grimes H, Henske EP, Iliopoulos O, Kurihara M, Lazor R, Linehan WM, Matsumoto K, Marciniak SJ, Namba Y, Pause A, Rajan N, Ray A, Schmidt LS, Shi W, Steinlein OK, Thierauf J, Zoncu R, Webb A, Mollapour M.
    • Journal Title

      Oncotarget

      Volume: 13 Issue: 1 Pages: 173-181

    • DOI

      10.18632/oncotarget.28176

    • Related Report
      2022 Research-status Report 2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] t(6; 11) renal cell carcinoma. A case report successfully diagnosed by using fluorescence in situ hybridization.2021

    • Author(s)
      Nishizawa H, Baba M, Furuya M, Kato I, Kurahashi R, Honda Y, Mikami Y, Nagashima Y, Eto M, Kamba T.
    • Journal Title

      IJU Case Rep.

      Volume: 4 Issue: 6 Pages: 375-378

    • DOI

      10.1002/iju5.12353

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Role of Flcn in the molecular regulation of kidney development2024

    • Author(s)
      Ola Shalaby, Takaaki Ito, Masaya Baba
    • Organizer
      第113回日本病理学会総会
    • Related Report
      2023 Annual Research Report
  • [Presentation] CRISPR/Cas9 genome wide screeningによる転座型腎細胞癌の転写制御機構の解明2024

    • Author(s)
      西澤秀和、舟崎慎太郎、穴見 俊樹、倉橋 竜磨、元島 崇信、村上 洋嗣、矢津田 旬二、馬場 理也、神波 大己
    • Organizer
      第54回腎癌研究会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Elucidation of Transcriptional regulation in Translocation Renal Cell Carcinoma Using CRISPR/Cas9 Genome-Wide Screening2024

    • Author(s)
      西澤秀和、舟崎慎太郎、穴見 俊樹、倉橋 竜磨、元島 崇信、村上 洋嗣、矢津田 旬二、馬場 理也、神波 大己
    • Organizer
      第111回日本泌尿器科学会総会
    • Related Report
      2023 Annual Research Report
  • [Presentation] CRISPR/Cas9 genome wide screeningによる転座型腎細胞癌の転写制御機構の解明2024

    • Author(s)
      西澤秀和、舟崎慎太郎、元島崇信、矢津田旬二、馬場理也、神波大己
    • Organizer
      第33回泌尿器科分子・細胞研究会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Xp11.2転座腎細胞癌における低酸素応答経路活性化による発癌メカニズムの解明2023

    • Author(s)
      舟崎 慎太郎、馬文娟、元島崇信、佐藤賢文、尾池雄一、蓮見壽史、須田年生、神波大己、馬場理也
    • Organizer
      第82回日本癌学会学術総会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Xp11.2転座腎細胞癌における低酸素応答経路活性化による発癌メカニズムの解明2023

    • Author(s)
      舟崎 慎太郎、馬文娟、元島崇信、西澤 秀和、蓮見壽史、佐藤賢文、尾池雄一、須田年生、神波大己、馬場理也
    • Organizer
      110回日本泌尿器科学会総会
    • Related Report
      2023 Annual Research Report
  • [Presentation] CRISPR/Cas9ゲノムワイドスクリーニングを用いた転座型腎細胞癌の発がん機構の解明2023

    • Author(s)
      西澤秀和, 舟崎慎太郎, 元島崇信, 矢津田旬二, 馬場理也, 神波大己
    • Organizer
      第32回泌尿器科分子・細胞研究会
    • Related Report
      2022 Research-status Report
  • [Presentation] CRISPR/Cas9 genome wide screening mediated clarification of carcinogenesis by a fusion TFE32022

    • Author(s)
      西澤秀和, 舟崎慎太郎, 元島崇信, 矢津田旬二, 馬場理也, 神波大己
    • Organizer
      第81回日本癌学会学術総会
    • Related Report
      2022 Research-status Report
  • [Presentation] Hypoxia response pathway controls tumor development in Xp11.2 translocation renal cell carcinoma2022

    • Author(s)
      Shintaro Funasaki, Wenjuan Ma, Takanobu Motoshima, Yorifumi Sato, Yuichi Oike, Hisashi Hasumi, Toshio Suda, Tomomi Kamba, Masaya Baba
    • Organizer
      第81回日本癌学会学術総会
    • Related Report
      2022 Research-status Report
  • [Presentation] 低酸素応答経路の活性化によるXp11.2転座型腎細癌発がんメカニズムの解明2022

    • Author(s)
      Shintaro Funasaki, Wenjuan Ma, Takanobu Motoshima, Yorifumi Satou, Yuichi Oike, Toshio Suda, Tomomi Kamba, Masaya Baba
    • Organizer
      第81 回日本癌学会学術総会
    • Related Report
      2021 Research-status Report
  • [Presentation] CRISPR/Cas9ゲノムワイドスクリーニングを用いた融合遺伝子TFE3による 発がんメカニズムの解明2022

    • Author(s)
      西澤秀和
    • Organizer
      第31回泌尿器科分子・細胞研究会
    • Related Report
      2021 Research-status Report
  • [Presentation] CRISPR/Cas9 genome wide screening mediated clarification of carcinogenesis by a fusion TFE32022

    • Author(s)
      西澤秀和、舟崎慎太郎、元島崇信、矢津田旬二、馬場理也、神波大己
    • Organizer
      第81回日本癌学会学術総会
    • Related Report
      2021 Research-status Report
  • [Presentation] Flcn role in blood and lymphatic system2021

    • Author(s)
      Masaya Baba
    • Organizer
      BHD Symposium 2021
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Xp11.2転座型腎細胞癌の薬剤耐性回避メカニズムの解明と転座型TFE3の活性抑制による新しい治療薬の開発2021

    • Author(s)
      Shintaro Funasaki, Sally Mehanna, Yasuhiko Kamikubo, Hiroshi Sugiyama, Shuji Ikeda, Yuichi Oike, Tomomi Kamba, Masaya Baba
    • Organizer
      Xp11.2転座型腎細胞癌の薬剤耐性回避メカニズムの解明と転座型TFE3の活性抑制による新しい治療薬の開発
    • Related Report
      2021 Research-status Report
  • [Presentation] t(6; 11) translocation renal cell carcinoma,successfully diagnosed by using FISH2021

    • Author(s)
      西澤秀和、倉橋竜磨、脊川卓也、元島崇信、村上洋嗣、杉山豊、矢津田旬二、山口隆大、 馬場理也、神波大己
    • Organizer
      The 37th KOREA-JAPAN Urological Congress
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] SILAC(Stable Isotope Labeling using Amino Acids in Cell Culture)による新規pVHL標的タンパク質の探索2021

    • Author(s)
      西澤秀和、上園英太、舟崎慎太郎、元島崇信、矢津田旬二、馬場理也、神波大己
    • Organizer
      第80回日本癌学会学術総会
    • Related Report
      2021 Research-status Report
  • [Presentation] Xp11.2転座型腎細胞癌で発現するキメラTFE3転写因子による低酸素応答経路の調節2021

    • Author(s)
      西澤秀和、元島崇信、馬文娟、舟崎慎太郎、蓮見壽史、佐藤賢文、古屋充子、長嶋洋治、 尾池雄一、馬場理也、神波大己
    • Organizer
      第109回日本泌尿器科学術会総会
    • Related Report
      2021 Research-status Report
  • [Remarks]

    • URL

      https://ircms.kumamoto-u.ac.jp/publications/2022/04/targeting-chemoresistance-in-xp112-translocation-renal-cell-carcinoma-using-a-novel-polyamide-chlora.html

    • Related Report
      2021 Research-status Report

URL: 

Published: 2021-07-13   Modified: 2025-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi