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Creation of cell response control method by electric charge -Cure viral infection and cancer with charged hydrogel

Research Project

Project/Area Number 21K19878
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 90:Biomedical engineering and related fields
Research InstitutionHokkaido University

Principal Investigator

Tanaka Shinya  北海道大学, 医学研究院, 教授 (70261287)

Project Period (FY) 2021-07-09 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2022: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2021: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywordsハイドロゲル / ウイルス感染 / がん幹細胞 / ウイルス
Outline of Research at the Start

医学の領域で感染症・がんは2大疾患であり、これらをわが国の科学力を持って制御することは喫緊の課題である。我々は最近、バイオマテリアルの1つであるハイドロゲルがヒト細胞に急速なゲノム変化を誘導することを見出した(Nat. Biomed. Eng, 2021)。本研究はこの技術を格段に発展させ、これまでにない斬新な発想で、細胞周囲の荷電状態を変化させることで細胞のゲノム状態を制御し、ウイルスへの感染を防御し、また、がん幹細胞を誘導することで、がんの早期診断法およびがん幹細胞特異的治療薬を開発する。最終的には、再生医療、未来医療を学術的に支える新学問領域「マテリアルゲノミクス」の確立を目指す。

Outline of Final Research Achievements

Infectious diseases and cancer are two major diseases, and their control is an urgent issue. We recently found that hydrogels induce rapid genomic changes in human cells (Nat. Biomed. Eng, 5, 914-925, 2021). In this research, this technology has been significantly developed, and the genomic state of cells was controlled by changing the charge (charge state) around cells using hydrogels. We found a charge condition that promoted viral proliferation and a charge condition that maximized the expression of cancer stem cell markers. This reveals the importance of specific pericellular charges in virus propagation and cancer stem cell creation.

Academic Significance and Societal Importance of the Research Achievements

本研究成果により、ウイルス増殖及びがん幹細胞の創出において、細胞周囲の特定のチャージ(荷電状態)が重要であることが明らかとなった。これらをコントロールすることで、ウイルス感染防御及びがん幹細胞標的治療法開発に繋がると期待される。 最終的には、再生医療、未来医療を学術的に支える新学問領域「マテリアルゲノミクス」の確立に繋がるものであり、社会的・学問的意義が大きい。

Report

(3 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • Research Products

    (57 results)

All 2023 2022 2021 Other

All Int'l Joint Research (1 results) Journal Article (27 results) (of which Int'l Joint Research: 10 results,  Peer Reviewed: 27 results,  Open Access: 18 results) Presentation (26 results) (of which Int'l Joint Research: 9 results,  Invited: 2 results) Book (1 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Int'l Joint Research] University Hospital Magdeburg(ドイツ)

    • Related Report
      2021 Research-status Report
  • [Journal Article] Geometrical analysis identified morphological features of hydrogel-induced cancer stem cells in synovial sarcoma model cells2023

    • Author(s)
      Ferdous Zannatul、Clement Jean-Emmanuel、Gong Jian Ping、Tanaka Shinya、Komatsuzaki Tamiki、Tsuda Masumi
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 642 Pages: 41-49

    • DOI

      10.1016/j.bbrc.2022.12.040

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Engineering of an electrically charged hydrogel implanted into a traumatic brain injury model for stepwise neuronal tissue reconstruction2023

    • Author(s)
      Tanikawa Satoshi、Ebisu Yuki、Seldacik Tomas、Semba Shingo、Nonoyama Takayuki、Kurokawa Takayuki、Hirota Akira、Takahashi Taiga、Yamaguchi Kazushi、Imajo Masamichi、Kato Hinako、Nishimura Takuya、Tanei Zen-ichi、Tsuda Masumi、Nemoto Tomomi、Gong Jian Ping、Tanaka Shinya
    • Journal Title

      Scientific Reports

      Volume: 13 Issue: 1 Pages: 2233-2233

    • DOI

      10.1038/s41598-023-28870-z

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Atelocollagen-associated autologous chondrocyte implantation for the repair of large cartilage defects of the knee: Results at three to seven years2023

    • Author(s)
      Kaibara Takuma、Kondo Eiji、Matsuoka Masatake、Iwasaki Koji、Onodera Tomohiro、Sakamoto Keita、Oda Yoshitaka、Tanei Zen-ichi、Momma Daisuke、Tanaka Shinya、Iwasaki Norimasa
    • Journal Title

      Journal of Orthopaedic Science

      Volume: - Issue: 1 Pages: 207-216

    • DOI

      10.1016/j.jos.2022.12.001

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Empagliflozin suppresses mitochondrial reactive oxygen species generation and mitigates the inducibility of atrial fibrillation in diabetic rats2023

    • Author(s)
      Koizumi Takuya、Watanabe Masaya、Yokota Takashi、Tsuda Masumi、Handa Haruka、Koya Jiro、Nishino Kotaro、Tatsuta Daishiro、Natsui Hiroyuki、Kadosaka Takahide、Koya Taro、Nakao Motoki、Hagiwara Hikaru、Kamada Rui、Temma Taro、Tanaka Shinya、Anzai Toshihisa
    • Journal Title

      Frontiers in Cardiovascular Medicine

      Volume: 10 Pages: 1005408-1005408

    • DOI

      10.3389/fcvm.2023.1005408

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A case of “genetically defined” radiation‐induced glioma: 29 years after surgery and radiation for pilocytic astrocytoma2023

    • Author(s)
      Masui Kenta、Nitta Masayuki、Muragaki Yoshihiro、Kawamata Takakazu、Satomi Kaishi、Matsushita Yuko、Yoshida Akihiko、Ichimura Koichi、Tsuda Masumi、Tanaka Shinya、Komori Takashi
    • Journal Title

      Neuropathology

      Volume: - Issue: 5 Pages: 425-428

    • DOI

      10.1111/neup.12903

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel rapid immunohistochemistry using an alternating current electric field identifies Rac and Cdc42 activation in human colon cancer FFPE tissues2022

    • Author(s)
      Tsuda M, Horio R, Wang L, Takenami T, Moriya J, Suzuka J, Sugino H, Tanei Z, Tanino M, Tanaka S.
    • Journal Title

      Sci Rep.

      Volume: 12 Issue: 1 Pages: 1733-1733

    • DOI

      10.1038/s41598-022-05892-7

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Attenuated fusogenicity and pathogenicity of SARS-CoV-2 Omicron variant2022

    • Author(s)
      Suzuki Rigel、Yamasoba Daichi、Kimura Izumi、Wang Lei他
    • Journal Title

      Nature

      Volume: 603 Issue: 7902 Pages: 700-705

    • DOI

      10.1038/s41586-022-04462-1

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Virological characteristics of the SARS-CoV-2 Omicron BA.2 spike2022

    • Author(s)
      Yamasoba Daichi、Kimura Izumi、Nasser Hesham他
    • Journal Title

      Cell

      Volume: 未定 Issue: 12 Pages: 2103-2115

    • DOI

      10.1016/j.cell.2022.04.035

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Evaluation of the context of downstream N- and free N-glycomic alterations induced by swainsonine in HepG2 cells2022

    • Author(s)
      Morikawa Chie、Sugiura Kanako、Kondo Keina、Yamamoto Yurie、Kojima Yuma、Ozawa Yurika、Yoshioka Hiroki、Miura Nobuaki、Piao Jinhua、Okada Kazue、Hanamatsu Hisatoshi、Tsuda Masumi、Tanaka Shinya、Furukawa Jun-ichi、Shinohara Yasuro
    • Journal Title

      Biochimica et Biophysica Acta (BBA) - General Subjects

      Volume: 1866 Issue: 9 Pages: 130168-130168

    • DOI

      10.1016/j.bbagen.2022.130168

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Virological characteristics of the SARS-CoV-2 Omicron BA.2 subvariants, including BA.4 and BA.52022

    • Author(s)
      Kimura et al.
    • Journal Title

      Cell

      Volume: 185 Issue: 21 Pages: 3992-4007

    • DOI

      10.1016/j.cell.2022.09.018

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Virological characteristics of the SARS-CoV-2 Omicron BA.2.75 variant2022

    • Author(s)
      Saito et al.
    • Journal Title

      Cell Host & Microbe

      Volume: 30 Issue: 11 Pages: 1540-1540

    • DOI

      10.1016/j.chom.2022.10.003

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Force-triggered rapid microstructure growth on hydrogel surface for on-demand functions2022

    • Author(s)
      Mu Qifeng、Cui Kunpeng、Wang Zhi Jian、Matsuda Takahiro、Cui Wei、Kato Hinako、Namiki Shotaro、Yamazaki Tomoko、Frauenlob Martin、Nonoyama Takayuki、Tsuda Masumi、Tanaka Shinya、Nakajima Tasuku、Gong Jian Ping
    • Journal Title

      Nature Communications

      Volume: 13 Issue: 1 Pages: 6213-6213

    • DOI

      10.1038/s41467-022-34044-8

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Machine Learning Algorithms: Prediction and Feature Selection for Clinical Refracture after Surgically Treated Fragility Fracture2022

    • Author(s)
      Shimizu Hirokazu、Enda Ken、Shimizu Tomohiro、Ishida Yusuke、Ishizu Hotaka、Ise Koki、Tanaka Shinya、Iwasaki Norimasa
    • Journal Title

      Journal of Clinical Medicine

      Volume: 11 Issue: 7 Pages: 2021-2021

    • DOI

      10.3390/jcm11072021

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical and radiological findings of glioblastomas harboring a BRAF V600E mutation2022

    • Author(s)
      Ishi Yukitomo、Yamaguchi Shigeru、Okamoto Michinari、Sawaya Ryosuke、Endo Shogo、Motegi Hiroaki、Terasaka Shunsuke、Tanei Zen-ichi、Hatanaka Kanako C.、Tanaka Shinya、Fujimura Miki
    • Journal Title

      Brain Tumor Pathology

      Volume: 39 Issue: 3 Pages: 162-170

    • DOI

      10.1007/s10014-022-00432-7

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neutrophil phenotypes implicated in the pathophysiology of post-traumatic sepsis2022

    • Author(s)
      Mizugaki Asumi、Wada Takeshi、Tsuchida Takumi、Oda Yoshitaka、Kayano Katsuhide、Yamakawa Kazuma、Tanaka Shinya
    • Journal Title

      Frontiers in Medicine

      Volume: 9 Pages: 982399-982399

    • DOI

      10.3389/fmed.2022.982399

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neoatherosclerosis with silent plaque rupture in a saphenous vein graft causing no re-flow phenomenon assessed by optical coherence tomography and histopathology2022

    • Author(s)
      Konishi Takao、Takahashi Yuki、Kazui Sho、Yasui Yutaro、Saiin Kohei、Naito Seiichiro、Takenaka Sakae、Mizuguchi Yoshifumi、Tada Atsushi、Kobayashi Yuta、Omote Kazunori、Sato Takuma、Kamiya Kiwamu、Nagai Toshiyuki、Tanaka Shinya、Anzai Toshihisa
    • Journal Title

      Cardiology Journal

      Volume: 29 Issue: 4 Pages: 718-719

    • DOI

      10.5603/cj.2022.0063

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vulnerable plaque derived from aspirated thrombi in recurrent acute coronary syndrome with familial hypercholesterolemia despite intensive lipid-lowering statin therapy2022

    • Author(s)
      Natsui Hiroyuki、Konishi Takao、Saiin Kohei、Tamaki Youji、Sato Tomoya、Takenaka Sakae、Tada Atsushi、Mizuguchi Yoshifumi、Kobayashi Yuta、Sato Takuma、Kamada Rui、Kamiya Kiwamu、Nagai Toshiyuki、Tanaka Shinya、Anzai Toshihisa
    • Journal Title

      Cardiology Journal

      Volume: 29 Issue: 2 Pages: 362-363

    • DOI

      10.5603/cj.2022.0018

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide CRISPR screen identifies CDK6 as a therapeutic target in adult T-cell leukemia/lymphoma2022

    • Author(s)
      Ishio Takashi、Kumar Sarvesh、Shimono Joji、Daenthanasanmak Anusara、Dubois Sigrid、Lin Yuquan、Bryant Bonita、Petrus Michael N.、Bachy Emmanuel、Huang Da Wei、Yang Yandan、Green Patrick L.、Hasegawa Hiroo、Maeda Michiyuki、Goto Hideki、Endo Tomoyuki、Yokota Takashi、Hatanaka Kanako C.、Hatanaka Yutaka、Tanaka Shinyaら
    • Journal Title

      Blood

      Volume: 139 Issue: 10 Pages: 1541-1556

    • DOI

      10.1182/blood.2021012734

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Enhanced fusogenicity and pathogenicity of SARS-CoV-2 Delta P681R mutation2021

    • Author(s)
      Saito Akatsuki、Irie Takashi、Suzuki Rigel、Maemura Tadashi、Nasser Hesham、Uriu Keiya、Kosugi Yusuke、Other 43 authors、Tanaka Shinya、Nakagawa So、Ikeda Terumasa、Fukuhara Takasuke、Kawaoka Yoshihiro、Sato Kei、The Genotype to Phenotype Japan (G2P-Japan) Consortium
    • Journal Title

      Nature

      Volume: 602 Issue: 7896 Pages: 300-306

    • DOI

      10.1038/s41586-021-04266-9

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Rapid reprogramming of tumour cells into cancer stem cells on double-network hydrogels2021

    • Author(s)
      Suzuka J, Tsuda M, Wang L, Kohsaka S, Kishida K, Semba S, Sugino H, Aburatani S, Frauenlob M, Kurokawa T, Kojima S, Ueno T, Ohmiya Y, Mano H, Yasuda K, Gong JP, Tanaka S
    • Journal Title

      Nat Biomed Eng

      Volume: - Issue: 8 Pages: 914-925

    • DOI

      10.1038/s41551-021-00692-2

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hydroxyapatite‐hybridized double‐network hydrogel surface enhances differentiation of bone marrow‐derived mesenchymal stem cells to osteogenic cells2021

    • Author(s)
      Kaibara Takuma、Wang Lei、Tsuda Masumi、Nonoyama Takayuki、Kurokawa Takayuki、Iwasaki Norimasa、Gong Jian Ping、Tanaka Shinya、Yasuda Kazunori
    • Journal Title

      Journal of Biomedical Materials Research Part A

      Volume: 110 Issue: 4 Pages: 747-760

    • DOI

      10.1002/jbm.a.37324

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Aberrant expression of MYD88 via RNA‐controlling CNOT4 and EXOSC3 in colonic mucosa impacts generation of colonic cancer2021

    • Author(s)
      Tsuda Masumi、Noguchi Misa、Kurai Tsuyoshi、Ichihashi Yuji、Ise Koki、Wang Lei、Ishida Yusuke、Tanino Mishie、Hirano Satoshi、Asaka Masahiro、Tanaka Shinya
    • Journal Title

      Cancer Science

      Volume: 112 Issue: 12 Pages: 5100-5113

    • DOI

      10.1111/cas.15157

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comprehensive molecular profiling of pulmonary pleomorphic carcinoma2021

    • Author(s)
      Nagano Masaaki、Kohsaka Shinji、Hayashi Takuo、Ueno Toshihide、Kojima Shinya、Shinozaki-Ushiku Aya、Morita Shigeki、Tsuda Masumi、Tanaka Shinya、Shinohara Toshiya、Omori Yuko、Sugaya Fumiko、Kato Hiroaki、Narita Yoshiaki、Nakajima Jun、Suzuki Kenji、Takamochi Kazuya、Mano Hiroyuki
    • Journal Title

      npj Precision Oncology

      Volume: 5 Issue: 1 Pages: 57-57

    • DOI

      10.1038/s41698-021-00201-3

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The CD44/COL17A1 Pathway Plays a Vital Role in the Formation of Multilayered, Transformed Epithelia.2021

    • Author(s)
      Kozawa K, ,Sekai M, Ohba K, Ito S, Sako H, Maruyama T, Kakeno M , Kuromiya K, Kamasaki T, Kohashi K, Ishikawa S, Sato N, Asano S, Suzuki H, Tanimura N, Mukai Y, Gotoh N, Tanino M, Tanaka S Natsuga K, Soga T. Nakamura T, Yabuta Y, Saitou M, Ito T, Matsuura K, Tsunoda M,et.al..
    • Journal Title

      Curr Biol

      Volume: 31 Issue: 14 Pages: 3086-3097

    • DOI

      10.1016/j.cub.2021.04.078

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cardiac-specific loss of mitoNEET expression is linked with age-related heart failure2021

    • Author(s)
      Furihata T, Takada S, Kakutani N, Maekawa S, Tsuda M, Matsumoto J, Mizushima W, Fukushima A, Yokota T, Enzan N, Matsushima S, Handa H, Fumoto Y, Nio-Kobayashi J, Iwanaga T, Tanaka S, Tsutsui H, Sabe H, Kinugawa S.
    • Journal Title

      Commun Biol.

      Volume: 4 Issue: 1 Pages: 138-138

    • DOI

      10.1038/s42003-021-01675-4

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Arid5a Promotes Immune Evasion by Augmenting Tryptophan Metabolism and Chemokine Expression2021

    • Author(s)
      Parajuli Gyanu、Tekguc Murat、Wing James B.、Hashimoto Ari、Okuzaki Daisuke、Hirata Takeshi、Sasaki Atsushi、Itokazu Takahide、Handa Haruka、Sugino Hirokazu、Nishikawa Yoshihiro、Metwally Hozaifa、Kodama Yuzo、Tanaka Shinya、Sabe Hisataka、Yamashita Toshihide、Sakaguchi Shimon、Kishimoto Tadamitsu、Hashimoto Shigeru
    • Journal Title

      Cancer Immunology Research

      Volume: 9 Issue: 8 Pages: 862-876

    • DOI

      10.1158/2326-6066.cir-21-0014

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Difference in the malignancy between RAS and GLI1-transformed astrocytes is associated with frequency of p27KIP1?positive cells in xenograft tissues2021

    • Author(s)
      Sasai Ken、Tabu Kouichi、Saito Takashi、Matsuba Yukio、Saido Takaomi C、Tanaka Shinya
    • Journal Title

      Pathology - Research and Practice

      Volume: 223 Pages: 153465-153465

    • DOI

      10.1016/j.prp.2021.153465

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Presentation] Analysis of regulatory mechanism of plasticity towards cancer stemness by hydrogels as biomaterial2022

    • Author(s)
      Shinya Tanaka, Jun Suzuka, Yoshitaka Oda, Yusuke Saitoh, Lei Wang, and Masumi Tsuda
    • Organizer
      第81回日本癌学会学術総会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Substrate charge regulates stemness of cancer and pluripotent stem cells via metabolic control of pluripotency factors2022

    • Author(s)
      Masamichi Imajo, Akira Hirota, Ryosuke Miyazaki, Jian-Ping Gong, Shinya Tanaka
    • Organizer
      The 40th Sapporo International Cancer Symposium
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analysis of characteristics of synovial sarcoma stem cells induced by synthetic polymer hydrogels2022

    • Author(s)
      Yuki Terashima, Masumi Tsuda, Kyosuke Fujishima, Kosei Nakamura, Lei Wang, Jian Ping Gong, Shinya Tanaka
    • Organizer
      The 40th Sapporo International Cancer Symposium
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Identification of new targets for pancreatic cancer stem cells using hydrogel and development of therapeutic methods2022

    • Author(s)
      Lei Wang, Yuma Aoki, Masumi Tsuda, Shinya Tanaka
    • Organizer
      The 40th Sapporo International Cancer Symposium
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Differences of the molecular mechanisims in dedifferentiation potential of breast cancer cells using hydrogels2022

    • Author(s)
      Jun Suzuka, Sumito Saeki, Kohei Kumegawa, Yoko Takahashi, Takayuki Ueno, Shinji Ohno, Masumi Tsuda, Shinya Tanaka, Reo Maruyama
    • Organizer
      The 40th Sapporo International Cancer Symposium
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analysis of cancer stem cells with invasive capacity by Hydrogel-Activated Reprogramming (HARP) phenomenon using PNaSS hydrogel2022

    • Author(s)
      Masumi Tsuda, Jun Suzuka, Yoshitaka Oda, Lei Wang, Yusuke Saito, Jian Ping Gong, Shinya Tanaka
    • Organizer
      12th AACR-JCA Joint Conference: Breakthroughs in Cancer Research: Translating Knowledge into Practice
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Hydrogel PCDME creates pancreatic cancer stem cells in OXPHOS metabolic state with TXNIP elevation2022

    • Author(s)
      Lei Wang, Yuma Aoki, Masumi Tsuda, Yusuke Saito, Takenori Kubota, Yoshitaka Oda, Satoshi Hirano, Jian Ping Gong, Shinya Tanaka
    • Organizer
      12th AACR-JCA Joint Conference: Breakthroughs in Cancer Research: Translating Knowledge into Practice
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analysis of pathological and biological roles for chemokine receptor CXCR4 identified via reprogramming by hydrogel in meningioma stem cells2022

    • Author(s)
      Yoshitaka Oda, Masumi Tsuda, Sayaka Yuzawa, Lei Wang, Satoshi Tanikawa, Zen-ichi Tanei, Christian Mawrin, Jian Ping Gong, Shinya Tanaka
    • Organizer
      12th AACR-JCA Joint Conference: Breakthroughs in Cancer Research: Translating Knowledge into Practice
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 細胞外基質の電位変化に伴うJCウイルス増殖の制御2022

    • Author(s)
      谷川聖、野々山貴行、津田真寿美、王磊、種井善一、Gong Jian Ping、田中伸哉
    • Organizer
      第111回日本病理学会総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 脊髄 capillary hemangioma の臨床病理学的特徴2022

    • Author(s)
      種井 善一,津田 真寿美,小田 義崇,谷川 聖,杉野 弘和,大竹 安史,今村 博幸,小柳 泉,飛騨 一利,田中伸哉
    • Organizer
      第111回日本病理学会総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 肺癌における新規作用機序チロシンキナーゼ阻害剤の解析2022

    • Author(s)
      津田真寿美、王磊、田中伸哉
    • Organizer
      第26回日本がん分子標的治療学会学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] ハイドロゲルを用いた膵癌幹細胞の新規ターゲットの同定及び治療法の開発2022

    • Author(s)
      王 磊、青木 佑磨、津田 真寿美、田中伸哉
    • Organizer
      第81回日本癌学会学術総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] ハイドロゲルを用いた髄膜腫がん幹細胞マーカーの検索2022

    • Author(s)
      小田 義崇、津田 真寿美、湯澤 明夏、王 磊、谷川 聖、種井善一、グン 剣萍、田中伸哉
    • Organizer
      第81回日本癌学会学術総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Analysis of cancer stem cells at invasive front niche2022

    • Author(s)
      Masumi Tsuda, Shinya Tanaka
    • Organizer
      第81回日本癌学会学術総会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] SARS-CoV-2変異株を用いたハムスター肺炎モデルの病理組織学的解析2022

    • Author(s)
      小田義崇、津田真寿美、王磊、谷川聖、種井善一、G2P-Japan、福原崇介、佐藤佳、 田中伸哉
    • Organizer
      第68回日本病理学会秋期特別総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 新規がん微小環境によるがん幹細胞の創出. DNゲルはオステオポンチンを介してがん細胞のリプログラミングを誘導する2021

    • Author(s)
      田中伸哉
    • Organizer
      第80回日本癌学会学術総会
    • Related Report
      2021 Research-status Report
  • [Presentation] ハイドロゲルを用いた悪性中皮腫細胞の幹細胞性誘導2021

    • Author(s)
      杉野弘和、王磊、津田真寿美、鈴鹿淳、谷野美智枝、グン剣萍、田中伸哉
    • Organizer
      第110回日本病理学会総会
    • Related Report
      2021 Research-status Report
  • [Presentation] ハイドロゲルによる癌幹細胞性の誘導を利用した髄膜腫の新規治療標的分子の検索2021

    • Author(s)
      小田義崇、津田真寿美、湯澤明夏、王磊、杉野弘和、鈴鹿淳、グン剣萍、田中伸哉
    • Organizer
      第110回日本病理学会総会
    • Related Report
      2021 Research-status Report
  • [Presentation] 高分子ハイドロゲルによるリプログラミングを利用した癌幹細胞標的治療薬の同定2021

    • Author(s)
      津田真寿美、鈴鹿淳、王磊、田中伸哉
    • Organizer
      第25回日本がん分子標的治療学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] Effect of scaffold stiffness on hydrogel-induced cancer stemness of cancer model cells2021

    • Author(s)
      Yanpeng Sun, Masumi Tsuda, Lei Wang, Hirokazu Sugino, Jian Ping Gong, Shinya Tanaka
    • Organizer
      The 39th Sapporo International Cancer Symposium
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Analysis of epigenetic characteristics of sarcoma stem cells induced by multifunctional hydrogels2021

    • Author(s)
      Yuheng Nie, Masumi Tsuda, Lei Wang, Jian Ping Gong, Shinya Tanaka
    • Organizer
      The 39th Sapporo International Cancer Symposium
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] 新規ハイドロゲルXはエピジェネティックな調節に関与しがん幹細胞性を誘導する2021

    • Author(s)
      鈴鹿 淳、津田 真寿美、王 磊、粂川 昂平、丸山 玲緒、田中 伸哉
    • Organizer
      第80回日本癌学会学術総会
    • Related Report
      2021 Research-status Report
  • [Presentation] 合成高分子ハイドロゲルを用いた滑膜肉腫幹細胞の細胞周期及びEMT/MET解析2021

    • Author(s)
      寺島祐樹、津田真寿美、藤島京祐、中村恒星、王磊、グン剣萍、田中伸哉
    • Organizer
      第44回日本分子生物学会年会
    • Related Report
      2021 Research-status Report
  • [Presentation] 高分子ハイドロゲルを用いた神経膠芽腫幹細胞の誘導メカニズムの解明2021

    • Author(s)
      藤島京祐、津田真寿美、王磊、グン剣萍、田中伸哉
    • Organizer
      第44回日本分子生物学会年会
    • Related Report
      2021 Research-status Report
  • [Presentation] ハイドロゲルを用いたグリオブラストーマにおける幹細胞マーカー発現制御シグナル経路の解析2021

    • Author(s)
      中村恒星、津田真寿美、寺島祐樹、藤島京祐、王磊、グン剣萍、田中伸哉
    • Organizer
      第44回日本分子生物学会年会
    • Related Report
      2021 Research-status Report
  • [Presentation] 基質電荷による多能性幹細胞の中胚葉分化制御機構の解析2021

    • Author(s)
      山川大輔、今城正道、廣田聡、田中伸哉
    • Organizer
      第44回日本分子生物学会年会
    • Related Report
      2021 Research-status Report
  • [Book] がんゲノム病理学2021

    • Author(s)
      田中伸哉、西原広史
    • Total Pages
      234
    • Publisher
      文光堂
    • Related Report
      2021 Research-status Report
  • [Remarks]

    • URL

      http://patho2.med.hokudai.ac.jp

    • Related Report
      2021 Research-status Report
  • [Patent(Industrial Property Rights)] 細胞培養器、細胞培養キット、および細胞培養方法2021

    • Inventor(s)
      黒川孝幸、勝山吉徳、グン剣萍、田中伸哉、津田真寿美
    • Industrial Property Rights Holder
      北海道大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2021-151208
    • Filing Date
      2021
    • Related Report
      2021 Research-status Report

URL: 

Published: 2021-07-13   Modified: 2024-01-30  

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