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Elucidating the Neural Basis of Hand Choice: Focusing on the Frontal-Parietal Network

Research Project

Project/Area Number 21K20293
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeMulti-year Fund
Review Section 0110:Psychology and related fields
Research InstitutionWaseda University

Principal Investigator

Hirayama Kento  早稲田大学, 人間科学学術院, その他(招聘研究員) (00907131)

Project Period (FY) 2021-08-30 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2022: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords手の選択 / 行動選択 / 意思決定 / 脳波 / 経頭蓋交流電気刺激法 / 神経リハビリテーション / 上肢選択 / 非侵襲的脳刺激法 / リハビリテーション / 非侵襲的脳画像法 / 行動選択意思決定 / 神経活動変調 / 脳の機能的結合 / ニューロイメージング
Outline of Research at the Start

脳卒中による片手の麻痺は,日常生活動作の障害となりやすいため問題になります。リハビリテーションによって,麻痺手がある程度使えるようになっても,普段の生活の中では,健常手で代償し,徐々に麻痺手を使わなくなってしまいます。これに対して,当事者が無意識に麻痺手を使いたくなるような介入が重要と考えました。本研究では,手の選択に関係する脳内ネットワークを明らかにするとともに,非侵襲的に脳活動を変調できる電気刺激法によってそのネットワークを変調したときの手の選択に対する影響を検討します。この刺激法が手の選択に影響することが明らかとなれば,麻痺手の使用を促すリハビリテーションに応用できる可能性があります。

Outline of Final Research Achievements

This study aimed to elucidate the brain networks involved in hand choice. By using EEG and non-invasive neuromodulation methods, we focused on the posterior parietal cortex (PPC) and the premotor cortex (PMC), which are predicted to play significant roles in hand choice, and investigated their relationship with hand choice. The EEG experiments suggested that the activities of the PPC and PMC in the 15-30 Hz and 45-60 Hz EEG frequency bands were highly correlated with hand choice. In the brain stimulation experiments, we have not yet collected the planned number of subject data and are currently continuing the measurements. This study suggests that the network between the PMC and PPC is crucial for hand choice.

Academic Significance and Societal Importance of the Research Achievements

本研究では、これまで明らかでなかった運動前野と後頭頂葉のネットワークが手の選択に重要な役割をもつことを、脳波計と脳刺激法を用いて示した。脳刺激法によって、手の選択傾向を変化させることができれば、脳卒中後の片麻痺患者の麻痺手の使用を促し、麻痺手の機能向上のためのリハビリテーションとして応用する可能性が期待される。今後は、脳卒中患者に対する臨床研究に発展させる予定である。

Report

(4 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • Research Products

    (11 results)

All 2024 2023 2022 2021

All Journal Article (4 results) (of which Int'l Joint Research: 2 results,  Open Access: 4 results,  Peer Reviewed: 2 results) Presentation (7 results) (of which Int'l Joint Research: 4 results,  Invited: 4 results)

  • [Journal Article] The Neuromodulation Method Biasing Arm Choice2023

    • Author(s)
      平山 健人、大須 理英子
    • Journal Title

      Journal of Physical Therapy Fundamentals

      Volume: 26 Issue: 1 Pages: 47-52

    • DOI

      10.24780/jjptf.JJPTF_2023-S04

    • ISSN
      2436-6382
    • Related Report
      2023 Annual Research Report
    • Open Access
  • [Journal Article] Somatosensory Stimulation on the Wrist Enhances the Subsequent Hand-Choice by Biasing Toward the Stimulated Hand2023

    • Author(s)
      Hirayama Kento、Takahashi Toru、Koga Takayuki、Osu Rieko
    • Journal Title

      Research Square

      Volume: 0 Pages: 0-0

    • DOI

      10.21203/rs.3.rs-3587580/v1

    • Related Report
      2023 Annual Research Report
    • Open Access / Int'l Joint Research
  • [Journal Article] Relevant factors for arm choice in reaching movement: a scoping review2022

    • Author(s)
      Hirayama Kento, Ito Yuki, Takahashi Toru, Osu Rieko.
    • Journal Title

      Journal of Physical Therapy Science

      Volume: 34 Issue: 12 Pages: 804-812

    • DOI

      10.1589/jpts.34.804

    • ISSN
      0915-5287, 2187-5626
    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Efficiency and Stability of Step-To Gait in Slow Walking2022

    • Author(s)
      Hirayama Kento、Otaka Yohei、Kurayama Taichi、Takahashi Toru、Tomita Yutaka、Inoue Seigo、Honaga Kaoru、Kondo Kunitsugu、Osu Rieko
    • Journal Title

      Frontiers in Human Neuroscience

      Volume: 15 Pages: 779920-779920

    • DOI

      10.3389/fnhum.2021.779920

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Brain Activity before Target Presentation Predicts Arm Choice2024

    • Author(s)
      Kento Hirayama, Kaoru Amemiya, Nicolas Schweighofer, Rieko Osu
    • Organizer
      Society for Neuroscience 2024
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Neural mechanisms of human hand-choice2023

    • Author(s)
      Kento Hirayama
    • Organizer
      The 5th Annual Neuromechanics and Motor Control Meeting
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 使う手の選択に影響を及ぼす神経活動変調法の紹介2023

    • Author(s)
      平山健人
    • Organizer
      第68回人間科学研究交流会
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] Effect of Reaching Duration on Arm Choice2022

    • Author(s)
      Kento Hirayama, Nicolas Schweighofer, Yannick Darmon, Rieko Osu
    • Organizer
      Society for Neuroscience 2022
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] 麻痺上肢の使用頻度アップを目指すニューロモジュレーション法の紹介2022

    • Author(s)
      平山健人
    • Organizer
      第27回基礎理学療法学会
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] 後頭頂葉への経頭蓋直流電気刺激が使う手の選択に及ぼす影響2022

    • Author(s)
      平山健人、大須理英子
    • Organizer
      第37回生体・生理工学シンポジウム
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] Electrical stimulation of the wrist biases human hand choice2021

    • Author(s)
      Kento Hirayama, Takayuki Koga, Rieko Osu.
    • Organizer
      The Annual Meeting of the Society for the Neural Control of Movement 2021
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research

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Published: 2021-10-22   Modified: 2025-01-30  

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