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Neural mechanisms of "reduced adaptation" in autism spectrum disorder from the perspetive of the perception to repetitive stimuli.

Research Project

Project/Area Number 21K20311
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeMulti-year Fund
Review Section 0110:Psychology and related fields
Research InstitutionNTT Communication Science Laboratories (2022)
National Rehabilitation Center for Persons with Disabilities (2021)

Principal Investigator

ITOI Chihiro  日本電信電話株式会社NTTコミュニケーション科学基礎研究所, 柏野多様脳特別研究室, リサーチアソシエイト (30912878)

Project Period (FY) 2021-08-30 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2022: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords自閉スペクトラム症 / 知覚 / 反復単語変形効果 / 順応 / 錯聴 / 神経反応
Outline of Research at the Start

ASDは反復提示された感覚刺激に対する神経反応が減弱しないために「順応しない」と捉えられてきた。順応するためには,感覚刺激に対して神経反応が減弱させる機能だけでなく,感覚刺激が提示されるごとに神経反応を適切に調節する機能も重要である。先行研究で,神経反応が減弱しないという前者のASDの順応機能の障害を検討した研究は数多く存在するものの,刺激の度に適切に反応を調整する機能の側面から,ASDの「慣れない」現象を検討した研究は少ない。そこで,本研究ではASDの「慣れない」現象の神経基盤の解明の足掛かりとして,ASDが物理的に同じ感覚刺激に対して多様な知覚を生成する脳機能に焦点を当てた検討を行う。

Outline of Final Research Achievements

In this study, we focused on differences in perception of repetitive stimuli in order to gain insight into the neural mechanisms underlying the "reduced adaptation" phenomenon of Autism Spectrum Disorder (ASD). Previous studies have focused on the characteristic that the neural response of ASD individuals to repetitive stimuli is not diminished, but on the other hand, the aspect that the neural response is highly variable has also been noted. We examined the differences in the perceptual content of ASD and typically developing individuals using the verbal transformation effect, a type of auditory illusionthat changes how we hear (perceive) words when repeatedly presented.However, the neural mechanisms associated with the differences in their perceptual content are not clear.
Therefore, we conducted preliminary experiments to investigate the neural mechanisms involved in the qualitative differences in the perception of ASD and typical developmental individuals to repetitive stimuli.

Academic Significance and Societal Importance of the Research Achievements

本研究成果は、自閉スペクトラム症者の生活上の困難の一つである「慣れなさ」を、感情的な反応の違いではなく、知覚そのものの違いから捉えることにより、そのメカニズムをより深く理解し、対応方法に関する知見を提供することに社会的意義がある。

Report

(3 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • Research Products

    (4 results)

All 2022

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (2 results)

  • [Journal Article] Sensitivity to interaural level and time differences in individuals with autism spectrum disorder2022

    • Author(s)
      H. Fujihira, C. Itoi, S. Furukawa, N. Kato, M. Kashino
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 19142-19142

    • DOI

      10.1038/s41598-022-23346-y

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Validation of the Japanese version of the Interoception Sensory Questionnaire for individuals with autism spectrum disorder2022

    • Author(s)
      Itoi Chihiro、Ujiie Yuta、Matsushima Kanae、Takahashi Kohske、Ide Masakazu
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 1-9

    • DOI

      10.1038/s41598-022-25883-y

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 自閉症者の白色ノイズへの交感神経応答は順化する2022

    • Author(s)
      大石悠貴,糸井千尋,加藤進昌,柏野牧夫
    • Organizer
      Neuro2022(第45回日本神経科学大会,第65回神経化学会大会,第32回神経回路学学会)
    • Related Report
      2022 Annual Research Report
  • [Presentation] Interoception Sensory Questionnaire (ISQ-J)の信頼性・妥当性の検討2022

    • Author(s)
      糸井千尋,氏家悠太,松島佳苗,髙橋康介,井手正和
    • Organizer
      日本心理学会第86回大会
    • Related Report
      2022 Annual Research Report

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Published: 2021-10-22   Modified: 2024-01-30  

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