Porous Microneedles filled with a Glucose-responsive Hydrogel for Self-Regulated Insulin Delivery
| Project/Area Number |
21K20525
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Multi-year Fund |
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| Review Section |
0403:Biomedical engineering and related fields
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| Research Institution | Kanagawa Institute of Industrial Sclence and Technology |
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Principal Investigator |
Barthelmes Kevin 地方独立行政法人神奈川県立産業技術総合研究所, 「貼るだけ人工膵臓」プロジェクト (松元P), 研究員(任期有) (60908078)
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| Project Period (FY) |
2021-08-30 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2022: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2021: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | Microneedle / Drug release / Hydrogel / Diabetes / Insulin / Encapsulation / microneedle / hydrogel / drug release |
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| Outline of Research at the Start |
Porous microneedles have great potential in transdermal medical drug delivery/body fluid absorption due to the permeability of interconnected pores. A novel approach by filling these pores with a hydrogel material could further increase the mechanical stability and retain high permeability.
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| Outline of Final Research Achievements |
Drug delivery across the skin (transdermal) offers a number of advantages. Compared to injections or oral administration it is non-invasive and drug degradation caused by digestion is prevented, respectively. Recently microneedle (MN) became popular for transdermal administration. They consist of a collection of tiny, needle-like structures that are typically less than a millimeter in length and are arranged in an array pattern on a substrate. MN devices create many small puncture holes in the skin whereby little to no pain is caused. This makes them minimally invasive and the drug can be delivered through the holes much more efficiently. MN arrays can be made from different materials and their morphology can be solid, hollow or porous. In this research report we explored different polymeric materials for porous MNs and filled the pores with another gel-like material. By this approach hybrid MNs were prepared with enhanced mechanical strength and good drug delivery capabilities.
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| Academic Significance and Societal Importance of the Research Achievements |
To increase mechanical stability, we permanently filled the pores, a process that has not been done very often in the literature. In addition, this method can prevent clogging of the pores through the absorption of body fluids and a sustained and long-term drug release can be maintained.
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Report
(3 results)
Research Products
(3 results)
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[Presentation] 高分子ゲルの階層的エンジニアリングによる持続型マイクロニードルデバイスの開発2021
Author(s)
松元 亮, Siyuan Chen, 宮崎 拓也, 伊藤 美智子, Barthelmes Kevin, 松本 裕子, 金井 紗綾香, 池原 清, 諸岡 由佳, 木村 慎一郎, 田中 都, 菅波 孝祥, 宮原 裕二
Organizer
第70回高分子討論会
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