Novel Diagnostics in Colorectal Tumors Using Artificial Intelligence and the Genetic Nature of Rapidly Developing Cancer

• Project/Area Number: 21K20881
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0902:General internal medicine and related fields
• Research Institution: Tokyo Medical University
• Principal Investigator: Yamaguchi Hayato 東京医科大学, 医学部, 助教 (90617721)
• Project Period (FY): 2021-08-30 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000); Fiscal Year 2022: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2021: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: Interval cancer / 大腸癌 / 人工知能 / AI / 急速発育癌 / interval cancer

Outline of Research at the Start

国際的に内視鏡検査精度が向上する一方で、短期間での検査間隔における急速発育癌の発生に関わる分子学的背景は未だ不透明である。人工知能（AI）を用いた大腸内視鏡診断支援システムは高精度かつリアルタイムでの病理診断予測を可能とした革新的な新規ツールの位置づけにあるが、遺伝子分野への応用例はない。本研究では、前癌病変に対するAI診断の基礎的研究を完成し、急速発育癌のバイオマーカー、遺伝子解析の全貌を解明する。この成果で、AIを基軸とした内視鏡診断、遺伝子診断を融合させた新規診断学を確立し、さらなる大腸癌減少への新たな波及効果を得たい。

Outline of Final Research Achievements

The average ADR, PDR, and SDR of the endoscopists were 31.3%, 68.3%, and 12.5%, respectively, for colonoscopy using automatic lesion detection support software based on artificial intelligence. Among patients with interval cancer, the >T1 cancers group had significantly more non-polypoid growth (NPG)-type cases than PG-type colorectal cancer cases, and some interval cancers grew rapidly from SSA/P in the right colon. This study suggests that if AI can identify true precursor lesions that should be endoscopically resected, it will provide new insights into rapidly growing cancer and have a ripple effect beyond the treatment of colorectal cancer.

Academic Significance and Societal Importance of the Research Achievements

国際的に内視鏡検査精度が向上する一方で、短期間での検査間隔における急速発育癌の発生に関わる分子学的背景は未だ不透明である。人工知能（AI）を用いた大腸内視鏡診断支援システムは高精度かつリアルタイムでの病理診断予測を可能とした革新的な新規ツールの位置づけにあるが、遺伝子分野への応用例はない。本研究では、前癌病変に対するAI診断の基礎的研究を完成し、急速発育癌のバイオマーカー、遺伝子解析の全貌を解明する。この成果で、AIを基軸とした内視鏡診断、遺伝子診断を融合させた新規診断学を確立し、さらなる大腸癌減少への新たな波及効果を得たい。

Research Products

• [Journal Article] Significance Of Rescue Hybrid Endoscopic Submucosal Dissection In Difficult Colorectal Cases (2023)
  • Author(s): Yamaguchi H, Fukuzawa M, Kawai T, Muramatsu T, Matsumoto T, Uchida K, Koyama Y, Madarame A, Morise T, Sugimoto A, Kono S, Naito S, Nagata N, Sugimoto M, Itoi T
  • Journal Title: Clinical endoscopy Volume: -
  • Peer Reviewed / Open Access
• [Journal Article] Visibility of early gastric cancers by texture and color enhancement imaging using a high-definition ultrathin transnasal endoscope (2023)
  • Author(s): Koyama Y, Sugimoto M, Kawai T, Mizumachi M, Yamanishi F, Matsumoto S, Suzuki Y, Nemoto D, Shinohara H, Ichimiya T, Muramatsu T, Kagawa Y, Matsumoto T, Madarame A, Morise T, Uchida K, Yamaguchi H, Kono S, Naito S, Fukuzawa M, Itoi T
  • Journal Title: Scientific Reports Volume: 13(1) Issue: 1 Pages: 1994-1994
  • DOI: 10.1038/s41598-023-29284-7
  • Peer Reviewed / Open Access
• [Journal Article] Targeted Metabolomic Profiling of Plasma Samples in Gastric Cancer by Liquid Chromatography-Mass Spectrometry (2022)
  • Author(s): Matsumoto Taisuke、Fukuzawa Masakatsu、Itoi Takao、Sugimoto Masahiro、Aizawa Yumi、Sunamura Makoto、Kawai Takashi、Koyama Yohei、Madarame Akira、Morise Takashi、Yamaguchi Hayato、Sugimoto Akihiko、Yamauchi Yoshiya、Kono Shin、Naito Sakiko
  • Journal Title: Digestion Volume: 104 Issue: 2 Pages: 97-108
  • DOI: 10.1159/000526864
  • Peer Reviewed
• [Journal Article] Prediction of depth of invasion and lymph node metastasis in superficial pharyngeal cancer by magnifying endoscopy using the Japan Esophageal Society Classification (2022)
  • Author(s): Yamaguchi H, Kawai T, Fukuzawa M, Nemoto D, Kagawa Y, Kono S, Naito S, Sato H, Nagata N, Sugimoto M, Tsukahara K, Itoi T
  • Journal Title: DEN open Volume: 3 Issue: 1
  • DOI: 10.1002/deo2.151
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy of endoscopic clip closure for nonperforated muscle layer exposure during esophageal endoscopic submucosal dissection (2022)
  • Author(s): Yamaguchi H, Fukuzawa M, Kawai T, Uchida K, Koyama Y, Madarame A, Morise T, Sugimoto A, Kono S, Naito S, Itoi T
  • Journal Title: Dis Esophagus Volume: 35(10)
  • DOI: 10.1093/dote/doac009
  • Peer Reviewed
• [Journal Article] Validation of the BEST-J score, a prediction model for bleeding after endoscopic submucosal dissection for early gastric cancer: a multicenter retrospective observational study (2022)
  • Author(s): Kagawa Y, Fukuzawa M, Sugimoto M, Madarame A, Yamaguchi H, Uchida K, Morise T, Koyama Y, Sugimoto A, Yamauchi Y, Kono S, Naito S, Yamamoto K, Kishimoto Y, Inuyama M, Kawai T, Itoi T
  • Journal Title: Surgical Endoscopy Volume: - Issue: 10 Pages: 7240-7249
  • DOI: 10.1007/s00464-022-09096-y
  • Peer Reviewed / Open Access
• [Journal Article] Diagnostic efficacy of the Japan NBI Expert Team classification with dual-focus magnification for colorectal tumors (2022)
  • Author(s): Koyama Y, Fukuzawa M, Kono S, Madarame A, Morise T, Uchida K, Yamaguchi H, Sugimoto A, Nagata N, Kawai T, Takamaru H, Sekiguchi M, Yamada M, Sakamoto T, Matsuda T, Saito Y, Itoi T
  • Journal Title: Surgical endoscopy Volume: 36(7) Issue: 7 Pages: 5032-5040
  • DOI: 10.1007/s00464-021-08863-7
  • Peer Reviewed
• [Presentation] AYA世代大腸癌における医療対策の現状と課題 (2023)
  • Author(s): 山口 隼
  • Organizer: 第98回 大腸癌研究会学術集会
• [Presentation] AYA(Adolescents and Young Adults)世代の大腸癌における臨床的特徴と医療対策 (2022)
  • Author(s): 山口 隼
  • Organizer: 第115回 日本消化器内視鏡学会関東支部例会