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Web-based screening of neurological diseases using pose estimator

Research Project

Project/Area Number 21K20891
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeMulti-year Fund
Review Section 0902:General internal medicine and related fields
Research InstitutionThe University of Tokyo

Principal Investigator

Sato Kenichiro  東京大学, 大学院医学系研究科(医学部), 助教 (10908495)

Project Period (FY) 2021-08-30 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2022: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords歩行解析 / 自動解析 / 姿勢推定 / 深層学習 / 時計描画テスト / 認知機能低下 / スクリーニング / AI / リモート診療 / 神経疾患 / 早期診断
Outline of Research at the Start

アルツハイマー病やパーキンソン病など神経疾患の診断/治療/薬剤開発においては、症状が明らかになってくる以前の、症状が軽微な前駆期から発症早期のうちに発見することが重要とされているが、症状が明らかでない段階から該当者を検出することは容易ではない。そのため、web入力形式による幅広い一般高齢者を対象としたリモートでの神経疾患の早期発見を、『姿勢推定を介した動画解析によって神経所見情報を抽出する手法』を組み入れることで可能にすることを目的とする。この研究により、神経疾患のweb上でのスクリーニングが実用レベルで可能になることが期待できる。

Outline of Final Research Achievements

We aimed to detect neurodegenerative diseases including Alzheimer's disease (AD) or Parkinson's disease (PD) by web-based applications available in smartphones, by attempting to develope two different methods: one is applying pose-estimating to 2D video movies recording gait, and another is deep learning-based prediction of cognitive decline from Clock-Drawing Test pictures. We started to take data of gait movies from preclinical AD participants. We also built deep learning prediction models to identify those with probable dementia or with executive dysfunction.

Academic Significance and Societal Importance of the Research Achievements

本研究の発展により、web上(含スマートフォン)での早期検出を目的としたアプリケーションを用意することができ、より幅広い人に利用してもらうことが可能になるため、従って神経疾患の早期発見がより多くの人で可能になるのではないかと期待できる。

Report

(3 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • Research Products

    (14 results)

All 2023 2022 2021

All Journal Article (11 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 11 results,  Open Access: 7 results) Presentation (3 results) (of which Int'l Joint Research: 3 results)

  • [Journal Article] Proteomic profile of nuclei containing p62-positive inclusions in a patient with neuronal intranuclear inclusion disease2023

    • Author(s)
      Kurihara Masanori、Mano Tatsuo、Eto Fumihiro、Yao Ikuko、Sato Kenichiro、Ohtomo Gaku、Bannai Taro、Shibata Shota、Ishiura Hiroyuki、Ikemura Masako、Matsubara Tomoyasu、Morishima Maho、Saito Yuko、Murayama Shigeo、Toda Tatsushi、Setou Mitsutoshi、Iwata Atsushi
    • Journal Title

      Neurobiology of Disease

      Volume: 177 Pages: 105989-105989

    • DOI

      10.1016/j.nbd.2023.105989

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Predicting the CTG Repeat Size from a Single Spirometry Test Performed at Any Time during the Disease Course of Myotonic Dystrophy Type 12022

    • Author(s)
      Katsuse K, Sato K, Tanaka N, Uchida I, Toda T, Mikata T, Motoyoshi Y.
    • Journal Title

      Internal Medicine

      Volume: 61 Issue: 15 Pages: 2281-2286

    • DOI

      10.2169/internalmedicine.8633-21

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2022-08-01
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Time to onset of drug-induced parkinsonism: Analysis using a large Japanese adverse event self-reporting database2022

    • Author(s)
      Sato Kenichiro、Niimi Yoshiki、Mano Tatsuo、Iwata Atsushi、Iwatsubo Takeshi
    • Journal Title

      BioScience Trends

      Volume: 16 Issue: 2 Pages: 151-157

    • DOI

      10.5582/bst.2022.01115

    • ISSN
      1881-7815, 1881-7823
    • Year and Date
      2022-04-30
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Preoperative factors associated with shunt responsiveness in patients with idiopathic normal-pressure hydrocephalus2022

    • Author(s)
      Uchigami Hirokazu、Sato Kenichiro、Samejima Naoyuki、Watanabe Akira、Kuwana Nobumasa、Tsuchida Takeyuki、Toda Tatsushi、Saito Masaaki
    • Journal Title

      Clinical Neurology and Neurosurgery

      Volume: 222 Pages: 107425-107425

    • DOI

      10.1016/j.clineuro.2022.107425

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Change in long-term care service usage in Japan following the COVID-19 pandemic: A survey using a nationwide statistical summary in 2018-2021.2022

    • Author(s)
      Sato K, Niimi Y, Iwatsubo T, Ishii S.
    • Journal Title

      Geriatr Gerontol Int.

      Volume: 22(9) Issue: 9 Pages: 803-809

    • DOI

      10.1111/ggi.14461

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Automated Evaluation of Conventional Clock-Drawing Test Using Deep Neural Network: Potential as a Mass Screening Tool to Detect Individuals With Cognitive Decline.2022

    • Author(s)
      Sato K, Niimi Y, Mano T, Iwata A, Iwatsubo T.
    • Journal Title

      Front Neurol.

      Volume: 13 Pages: 896403-896403

    • DOI

      10.3389/fneur.2022.896403

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Efficacy and cost-effectiveness of multiple promotion methods to recruit participants to an online screening registry to facilitate Alzheimer’s disease prevention trials: observational study of website access and registration (Preprint)2021

    • Author(s)
      Sato Kenichiro、Niimi Yoshiki、Ihara Ryoko、Suzuki Kazushi、Toda Tatsushi、Iwata Atsushi、Iwatsubo Takeshi
    • Journal Title

      Journal of Medical Internet Research

      Volume: 23(7) Issue: 7 Pages: e26284-e26284

    • DOI

      10.2196/26284

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Disproportionality by sex in the prescription of drugs capable of inducing parkinsonism for the elderly: A survey using statistics of Japanese national health claims from 2014 to 20172021

    • Author(s)
      Sato K, Mano T, Iwata A, Toda T
    • Journal Title

      Neurology and Clinical Neuroscience

      Volume: 9 Issue: 3 Pages: 211-217

    • DOI

      10.1111/ncn3.12501

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cohort-Specific Optimization of Models Predicting Preclinical Alzheimer’s Disease, to Enhance Screening Performance in the Middle of Preclinical Alzheimer’s Disease Clinical Studies2021

    • Author(s)
      Sato K.、Mano T.、Ihara R.、Suzuki K.、Niimi Y.、Toda T.、Iwatsubo T.、Iwata A.
    • Journal Title

      The Journal Of Prevention of Alzheimer's Disease

      Volume: 8 Issue: 4 Pages: 1-10

    • DOI

      10.14283/jpad.2021.39

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Safety of Memantine in Combination with Potentially Interactive Drugs in the Real World: A Pharmacovigilance Study Using the Japanese Adverse Drug Event Report (JADER) Database2021

    • Author(s)
      Sato K, Mano T, Iwata A, Toda T.
    • Journal Title

      J Alzheimers Dis

      Volume: 82 Issue: 3 Pages: 1333-1344

    • DOI

      10.3233/jad-210524

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Need of care in interpreting Google Trends-based COVID-19 infodemiological study results: potential risk of false-positivity2021

    • Author(s)
      Sato Kenichiro、Mano Tatsuo、Iwata Atsushi、Toda Tatsushi
    • Journal Title

      BMC Medical Research Methodology

      Volume: 21 Issue: 1 Pages: 147-147

    • DOI

      10.1186/s12874-021-01338-2

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Adverse events reported in association with APOE-ε4 allele(s) from placebo arm of clinical trials for Alzheimer’s disease2023

    • Author(s)
      Kenichiro Sato, Yoshiki Niimi, Ryoko Ihara, Kazushi Suzuki, Atsushi Iwata, and Takeshi Iwatsubo
    • Organizer
      ADPD
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Safety of fluorine 18-labeled amyloid tracers: pharmacovigilance validation using a large real-world database2022

    • Author(s)
      Kenichiro Sato, Yoshiki Niimi, Ryoko Ihara, Kazushi Suzuki, Atsushi Iwata and Takeshi Iwatsubo
    • Organizer
      CTAD
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Frequency of preclinical Alzheimer’s disease in Japanese clinical study settings: A meta‐analysis2021

    • Author(s)
      Sato K, Niimi Y, Ihara R, Suzuki K, Iwata A, Iwatsubo T
    • Organizer
      The Alzheimer's Association International Conference
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research

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Published: 2021-10-22   Modified: 2024-01-30  

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