The combined application of mineral trioxide aggregate containing phosphorylated pullulan and colloidal platinum nanoparticles to control inflammation and facilitate dental pulp regeneration
| Project/Area Number |
21K21028
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Multi-year Fund |
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| Review Section |
0907:Oral science and related fields
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| Research Institution | Hokkaido University |
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Principal Investigator |
Islam Rafiqul 北海道大学, 歯学研究院, 助教 (00906414)
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| Project Period (FY) |
2021-08-30 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2022: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2021: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | Direct pulp capping / MTA / CPNs / Pullulan / Platinum Nanoparticles / Phosphorylated pullulan / Dental pulp / Dental Pulp Regeneration / Direct Pulp Capping / Phosphorylated Pullulan |
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| Outline of Research at the Start |
Phosphorylated pullulan has recently been combined with MTA due to its capability to work as a carrier for growth factors in hard tissue engineering. CPN is an antioxidant and has the healing ability. Based on the above-mentioned properties of CPN and MTAPPL, the combination of these materials might be an ideal material for dental pulp regeneration.
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| Outline of Final Research Achievements |
The study aimed to evaluate the potential of a combination of mineral trioxide aggregate and phosphorylated pullulan for direct pulp capping (DPC), a dental procedure that involves placing a material directly on an exposed pulp to promote healing and prevent infection. We compared the effectiveness of the novel MTAPPL material to that of conventional MTA in inducing mineralized tissue formation and inflammatory pulpal responses. The results showed that MTAPPL exhibits comparable outcomes to MTA, indicating its potential as a viable alternative for DPC.
Additionally, the study investigated the healing response of colloidal platinum nanoparticles (CPNs) in exposed dental pulp. We found that the presence of endothelial cells, which are involved in angiogenesis, were present in the dental pulp after treatment with CPNs, indicating a favorable healing response. Overall, the study suggests that the combination of MTAPPL and CPNs hold promise for use in dental pulp therapy.
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| Academic Significance and Societal Importance of the Research Achievements |
Using CPNs and MTAPPL has significant impact in the dental field. The study develops new materials and approaches for dental pulp therapy, overcoming limitations of traditional materials and leading to better patient outcomes and quality of life.
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Report
(3 results)
Research Products
(11 results)
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[Journal Article] Pulpal response to mineral trioxide aggregate containing phosphorylated pullulan-based capping material2022
Author(s)
Yu Toida, Shimpei Kawano, Rafiqul Islam, Fu Jiale, Afm A Chowdhury, Shuhei Hoshika, Yasushi Shimada, Junji Tagami, Masahiro Yoshiyama, Satoshi Inoue, Ricardo M Carvalho, Yasuhiro Yoshida, Hidehiko Sano
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Journal Title
Dental Materials Journal
Volume: 41
Issue: 1
Pages: 126-133
DOI
NAID
ISSN
0287-4547, 1881-1361
Year and Date
2022-01-25
Related Report
Peer Reviewed / Int'l Joint Research
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