| Project/Area Number |
21K21094
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Multi-year Fund |
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| Review Section |
0907:Oral science and related fields
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| Research Institution | Health Sciences University of Hokkaido |
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Principal Investigator |
Paudel Durga 北海道医療大学, 先端研究推進センター, 助教 (20910590)
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| Project Period (FY) |
2021-08-30 – 2024-03-31
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| Project Status |
Completed (Fiscal Year 2023)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2022: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | psychology / stress / oral cavity / saliva / oral microbiota / amitriptyline / RNA seq / salivary glands / psychological stress / salivary gland / trancriptome / RNA-seq / salivary protein / genome wide analyses / post menopause / oral microbiome |
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| Outline of Research at the Start |
Post-menopausal females undergo symptoms such as hot flushes, vaginal atrophy, osteoporosis, and sexual problems in post-menopausal females are linked to estrogen deficiency. Apart from these symptoms, studies show that post-menopausal females experience psychological stress and anxiety more frequently.
Several oral symptoms and diseases of unknown etiology are prevalent in post-menopausal females. Therefore, the extensive study of proteins, gene and microbiome in oral cavity of an animal model of post-menopausal state with psychological stress may elucidate the involved mechanisms.
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| Outline of Final Research Achievements |
The study aimed to explore if psychological stress and postmenopausal conditions can affect the gene expression, protein expression, and microbiota in the oral cavity including saliva and salivary glands. We demonstrated two important findings: 1) The drugs used to relieve or treat psychological stress can affect the microbiota in the oral cavity. 2) Psychological stress affects gene expression and protein expression in salivary glands, which can alter salivary rate or flow. These findings have been published in two different international journals as a research paper.
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| Academic Significance and Societal Importance of the Research Achievements |
The findings of our study will aid in understanding the effect of psychological stress and drugs used to relieve psychological stress on the oral cavity in gene expression, protein expression, and microbiota.
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